Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis
ABSTRACT: The influence of cytokine on the progression of chronic periodontitis in human immunodeficiency virus (HIV) patients is still controversial and poorly investigated. This study aimed to analyze and compare IL-6 and IFN-α levels in the gingival crevicular fluid of HIV-1-positive and...
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Universidad de La Frontera. Facultad de Medicina
2018
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oai:scielo:S0718-381X20180003002192018-10-26Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic PeriodontitisMenezes,Sílvio Augusto Fernandes deAraújo,Vera Cavalcente deNapimoga,Marcelo HenriqueMenezes,Tatiany Oliveira de AlencarNogueira,Brenna Magdalena LimaFonseca,Ricardo Roberto de SouzaMartinez,Elizabeth Fernandes HIV-AIDS periodontal disease cytokine ABSTRACT: The influence of cytokine on the progression of chronic periodontitis in human immunodeficiency virus (HIV) patients is still controversial and poorly investigated. This study aimed to analyze and compare IL-6 and IFN-α levels in the gingival crevicular fluid of HIV-1-positive and HIV-1-negative patients with chronic periodontitis and different grades of tissue destruction and inflammation. Samples from the gingival crevicular sulcus were obtained from 35 HIV-1-positive individuals with chronic periodontitis and 35 seronegative patients with chronic periodontitis. Probing depth and clinical attachment level, as well as the results of the Enzyme-Linked Immunosorbent Assay for confirmation of patient diagnostics, were evaluated. Statistical analyses were performed using Student t, Mann-Whitney and Spearman tests. IL-6 levels were significantly lower, while IFN-α levels were significantly higher in HIV-1 patients. Clinical attachment level was directly associated with IFN-α levels in HIV-1 carriers, connected to probing depth in these patients. Clinical data in association with gingival crevicular fluid cytokine levels may reveal a localized immunological response pattern, which may contribute to the understanding of periodontitis pathogenesis in HIV-1 carriers.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.12 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000300219en10.4067/S0718-381X2018000300219 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
HIV-AIDS periodontal disease cytokine |
| spellingShingle |
HIV-AIDS periodontal disease cytokine Menezes,Sílvio Augusto Fernandes de Araújo,Vera Cavalcente de Napimoga,Marcelo Henrique Menezes,Tatiany Oliveira de Alencar Nogueira,Brenna Magdalena Lima Fonseca,Ricardo Roberto de Souza Martinez,Elizabeth Fernandes Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis |
| description |
ABSTRACT: The influence of cytokine on the progression of chronic periodontitis in human immunodeficiency virus (HIV) patients is still controversial and poorly investigated. This study aimed to analyze and compare IL-6 and IFN-α levels in the gingival crevicular fluid of HIV-1-positive and HIV-1-negative patients with chronic periodontitis and different grades of tissue destruction and inflammation. Samples from the gingival crevicular sulcus were obtained from 35 HIV-1-positive individuals with chronic periodontitis and 35 seronegative patients with chronic periodontitis. Probing depth and clinical attachment level, as well as the results of the Enzyme-Linked Immunosorbent Assay for confirmation of patient diagnostics, were evaluated. Statistical analyses were performed using Student t, Mann-Whitney and Spearman tests. IL-6 levels were significantly lower, while IFN-α levels were significantly higher in HIV-1 patients. Clinical attachment level was directly associated with IFN-α levels in HIV-1 carriers, connected to probing depth in these patients. Clinical data in association with gingival crevicular fluid cytokine levels may reveal a localized immunological response pattern, which may contribute to the understanding of periodontitis pathogenesis in HIV-1 carriers. |
| author |
Menezes,Sílvio Augusto Fernandes de Araújo,Vera Cavalcente de Napimoga,Marcelo Henrique Menezes,Tatiany Oliveira de Alencar Nogueira,Brenna Magdalena Lima Fonseca,Ricardo Roberto de Souza Martinez,Elizabeth Fernandes |
| author_facet |
Menezes,Sílvio Augusto Fernandes de Araújo,Vera Cavalcente de Napimoga,Marcelo Henrique Menezes,Tatiany Oliveira de Alencar Nogueira,Brenna Magdalena Lima Fonseca,Ricardo Roberto de Souza Martinez,Elizabeth Fernandes |
| author_sort |
Menezes,Sílvio Augusto Fernandes de |
| title |
Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis |
| title_short |
Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis |
| title_full |
Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis |
| title_fullStr |
Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis |
| title_full_unstemmed |
Interleukin-6 and Interferon-α Levels in Gingival Crevicular Fluid in HIV-1 Patients with Chronic Periodontitis |
| title_sort |
interleukin-6 and interferon-α levels in gingival crevicular fluid in hiv-1 patients with chronic periodontitis |
| publisher |
Universidad de La Frontera. Facultad de Medicina |
| publishDate |
2018 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000300219 |
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