Juvenile Xanthogranuloma: A Case Report and Review of the Literature

SUMMARY: Juvenile xanthogranuloma (JXG), is a benign histiocytic proliferation of uncertain histiogenesis which was first described by Adamson in 1905. It is a regressing disorder which occurs in children usually within first year of life. A child of ten months age reported to the Azeezia College of...

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Autores principales:	Raj,Divya, Rathy,R
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2018
Materias:	Juvenile xanthogranuloma case report
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000300327
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spelling	oai:scielo:S0718-381X20180003003272018-10-26Juvenile Xanthogranuloma: A Case Report and Review of the LiteratureRaj,DivyaRathy,R Juvenile xanthogranuloma case report SUMMARY: Juvenile xanthogranuloma (JXG), is a benign histiocytic proliferation of uncertain histiogenesis which was first described by Adamson in 1905. It is a regressing disorder which occurs in children usually within first year of life. A child of ten months age reported to the Azeezia College of Dental Sciences and Research with a nodular swelling on the right side of the cheek and gave a history of swelling since the age of 5 months with gradual increase in size which was not associated with pain or itching. A provisional diagnosis of Haemangioma was made and excision biopsy of the lesion was done under general anaesthetia. Depending on the histopathologic and immunohistochemical findings a diagnosis of Juvenile Xanthogranuloma was made. The excisional biopsy site healed uneventfully with minimal scar formation. JXG is a benign fibrohistiocytic lesion and a type of granulomatous process. Pathogenesis of the lesion is unknown. It is generally considered to be a reactive lesion. Most common presentation is as solitary cutaneous lesion. Children are affected at a median age of 2 years with a male female ratio of 1.5:1. Classic histopathologic findings include Nodular to diffuse collection of histiocytes with finely vacuolated foamy cytoplasm and round to oval nuclei, Touton giant cells which are the cells with a central wreath of nuclei and peripheral rim of eosinophilic to vacuolated cytoplasm loaded with fat and Inflammatory infiltrate such as lymphocytes and eosinophils. JXG has to be clinically differentiated from Xanthoma, Molluscum contagiosum, Haemangioma and Neurofibroma. Mostly a self-limiting disease which spontaneously resolves. Conservative management is the treatment of choice. Excision may be done due to esthetic and diagnostic reasons. Recurrence is uncommon. JXG is a disease predominantly of early childhood, benign and self-healing.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.12 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000300327en10.4067/S0718-381X2018000300327
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Juvenile xanthogranuloma case report
spellingShingle	Juvenile xanthogranuloma case report Raj,Divya Rathy,R Juvenile Xanthogranuloma: A Case Report and Review of the Literature
description	SUMMARY: Juvenile xanthogranuloma (JXG), is a benign histiocytic proliferation of uncertain histiogenesis which was first described by Adamson in 1905. It is a regressing disorder which occurs in children usually within first year of life. A child of ten months age reported to the Azeezia College of Dental Sciences and Research with a nodular swelling on the right side of the cheek and gave a history of swelling since the age of 5 months with gradual increase in size which was not associated with pain or itching. A provisional diagnosis of Haemangioma was made and excision biopsy of the lesion was done under general anaesthetia. Depending on the histopathologic and immunohistochemical findings a diagnosis of Juvenile Xanthogranuloma was made. The excisional biopsy site healed uneventfully with minimal scar formation. JXG is a benign fibrohistiocytic lesion and a type of granulomatous process. Pathogenesis of the lesion is unknown. It is generally considered to be a reactive lesion. Most common presentation is as solitary cutaneous lesion. Children are affected at a median age of 2 years with a male female ratio of 1.5:1. Classic histopathologic findings include Nodular to diffuse collection of histiocytes with finely vacuolated foamy cytoplasm and round to oval nuclei, Touton giant cells which are the cells with a central wreath of nuclei and peripheral rim of eosinophilic to vacuolated cytoplasm loaded with fat and Inflammatory infiltrate such as lymphocytes and eosinophils. JXG has to be clinically differentiated from Xanthoma, Molluscum contagiosum, Haemangioma and Neurofibroma. Mostly a self-limiting disease which spontaneously resolves. Conservative management is the treatment of choice. Excision may be done due to esthetic and diagnostic reasons. Recurrence is uncommon. JXG is a disease predominantly of early childhood, benign and self-healing.
author	Raj,Divya Rathy,R
author_facet	Raj,Divya Rathy,R
author_sort	Raj,Divya
title	Juvenile Xanthogranuloma: A Case Report and Review of the Literature
title_short	Juvenile Xanthogranuloma: A Case Report and Review of the Literature
title_full	Juvenile Xanthogranuloma: A Case Report and Review of the Literature
title_fullStr	Juvenile Xanthogranuloma: A Case Report and Review of the Literature
title_full_unstemmed	Juvenile Xanthogranuloma: A Case Report and Review of the Literature
title_sort	juvenile xanthogranuloma: a case report and review of the literature
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000300327
work_keys_str_mv	AT rajdivya juvenilexanthogranulomaacasereportandreviewoftheliterature AT rathyr juvenilexanthogranulomaacasereportandreviewoftheliterature
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Juvenile Xanthogranuloma: A Case Report and Review of the Literature

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