Late Diagnosis of Oral Melanoma

ABSTRACT: Oral melanoma (OM) is an extremely rare and aggressive malignancy. A 67-year-old patient presented with complains of a slightly symptomatic spot in the mouth since the past 2 years. Extraoral examination revealed left cervical lymphadenopathy, and intraoral examination a blue-black multino...

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Autores principales:	Santana,Lucas Alves da Mota, Cunha,John Lennon Silva, Ribeiro,Thiago Santana, Sánchez-Romero,Celeste, Trento,Cleverson Luciano, Marqueti,Antônio Carlos, de Albuquerque-Júnior,Ricardo Luiz Cavalcanti, Sousa,Sílvia Ferreira de
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2019
Materias:	head and neck cancer melanoma oral melanoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2019000200230
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spelling	oai:scielo:S0718-381X20190002002302020-12-10Late Diagnosis of Oral MelanomaSantana,Lucas Alves da MotaCunha,John Lennon SilvaRibeiro,Thiago SantanaSánchez-Romero,CelesteTrento,Cleverson LucianoMarqueti,Antônio Carlosde Albuquerque-Júnior,Ricardo Luiz CavalcantiSousa,Sílvia Ferreira de head and neck cancer melanoma oral melanoma ABSTRACT: Oral melanoma (OM) is an extremely rare and aggressive malignancy. A 67-year-old patient presented with complains of a slightly symptomatic spot in the mouth since the past 2 years. Extraoral examination revealed left cervical lymphadenopathy, and intraoral examination a blue-black multinodular sessile mass, with irregular margins, involving the attached gingiva of teeth 27 and 28, extending to vestibular sulcus and hard palate, measuring approximately 3.5 cm. The lesion presented focal areas of ulceration. Panoramic radiograph did not show bone involvement. The main diagnostic hypothesis was oral melanoma. Microscopic findings of the incisional biopsy revealed a proliferation of densely pigmented pleomorphic cells, invading the subepithelial connective tissue in sheets or nests showing an organoid pattern. Immunopositivity for S-100, Melan-A and HMB-45 confirmed the diagnosis of melanoma. The patient was referred to an oncology hospital in which multiple metastases were detected, and the patient was subjected to palliative care. Herein we report an OM in advanced clinical stage, and discuss the clinical, morphological and immunohistochemical diagnostic criteria with emphasis on the importance of early diagnosis.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.13 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2019000200230en10.4067/S0718-381X2019000200230
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	head and neck cancer melanoma oral melanoma
spellingShingle	head and neck cancer melanoma oral melanoma Santana,Lucas Alves da Mota Cunha,John Lennon Silva Ribeiro,Thiago Santana Sánchez-Romero,Celeste Trento,Cleverson Luciano Marqueti,Antônio Carlos de Albuquerque-Júnior,Ricardo Luiz Cavalcanti Sousa,Sílvia Ferreira de Late Diagnosis of Oral Melanoma
description	ABSTRACT: Oral melanoma (OM) is an extremely rare and aggressive malignancy. A 67-year-old patient presented with complains of a slightly symptomatic spot in the mouth since the past 2 years. Extraoral examination revealed left cervical lymphadenopathy, and intraoral examination a blue-black multinodular sessile mass, with irregular margins, involving the attached gingiva of teeth 27 and 28, extending to vestibular sulcus and hard palate, measuring approximately 3.5 cm. The lesion presented focal areas of ulceration. Panoramic radiograph did not show bone involvement. The main diagnostic hypothesis was oral melanoma. Microscopic findings of the incisional biopsy revealed a proliferation of densely pigmented pleomorphic cells, invading the subepithelial connective tissue in sheets or nests showing an organoid pattern. Immunopositivity for S-100, Melan-A and HMB-45 confirmed the diagnosis of melanoma. The patient was referred to an oncology hospital in which multiple metastases were detected, and the patient was subjected to palliative care. Herein we report an OM in advanced clinical stage, and discuss the clinical, morphological and immunohistochemical diagnostic criteria with emphasis on the importance of early diagnosis.
author	Santana,Lucas Alves da Mota Cunha,John Lennon Silva Ribeiro,Thiago Santana Sánchez-Romero,Celeste Trento,Cleverson Luciano Marqueti,Antônio Carlos de Albuquerque-Júnior,Ricardo Luiz Cavalcanti Sousa,Sílvia Ferreira de
author_facet	Santana,Lucas Alves da Mota Cunha,John Lennon Silva Ribeiro,Thiago Santana Sánchez-Romero,Celeste Trento,Cleverson Luciano Marqueti,Antônio Carlos de Albuquerque-Júnior,Ricardo Luiz Cavalcanti Sousa,Sílvia Ferreira de
author_sort	Santana,Lucas Alves da Mota
title	Late Diagnosis of Oral Melanoma
title_short	Late Diagnosis of Oral Melanoma
title_full	Late Diagnosis of Oral Melanoma
title_fullStr	Late Diagnosis of Oral Melanoma
title_full_unstemmed	Late Diagnosis of Oral Melanoma
title_sort	late diagnosis of oral melanoma
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2019000200230
work_keys_str_mv	AT santanalucasalvesdamota latediagnosisoforalmelanoma AT cunhajohnlennonsilva latediagnosisoforalmelanoma AT ribeirothiagosantana latediagnosisoforalmelanoma AT sanchezromeroceleste latediagnosisoforalmelanoma AT trentocleversonluciano latediagnosisoforalmelanoma AT marquetiantoniocarlos latediagnosisoforalmelanoma AT dealbuquerquejuniorricardoluizcavalcanti latediagnosisoforalmelanoma AT sousasilviaferreirade latediagnosisoforalmelanoma
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Late Diagnosis of Oral Melanoma

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