BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION

ABSTRACT This paper has three parts. In the first part we introduce G. Munévar's hypothesis about the neuroscience of bipolar disorder. According to this hypothesis, bipolar disorder is a failure of interhemispheric inhibition in the frontal lobe. When the electrical activation of the left side...

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Autores principales:	Munévar,Gonzalo, Shaver,Alyssa, Cole,Matthew
Lenguaje:	Spanish / Castilian
Publicado:	Universidad de Tarapacá. Escuela de Psicología y Filosofía 2018
Materias:	Neurociencia trastorno bipolar estimulación de corriente continua transcraneal tomografía electro magnética ponderada estandarizada de baja resolución
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-50652018000300080
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spelling	oai:scielo:S0718-506520180003000802019-08-12BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITIONMunévar,GonzaloShaver,AlyssaCole,Matthew Neurociencia trastorno bipolar estimulación de corriente continua transcraneal tomografía electro magnética ponderada estandarizada de baja resolución ABSTRACT This paper has three parts. In the first part we introduce G. Munévar's hypothesis about the neuroscience of bipolar disorder. According to this hypothesis, bipolar disorder is a failure of interhemispheric inhibition in the frontal lobe. When the electrical activation of the left side overwhelms that of the right, the left frontal lobe dominates, thus leading to exaggerated states of ela tion (or others that also constitute mania). Dominance in activation by the right side, in turn, leads to states of depression. The neuroscience literature already offers a large amount of support for this hypothesis, as we explain. The second part describes our own study using transcranial direct current stimulation (tDCS) to successfully decrease positive moods in 25 healthy individuals. This result was obtained by connecting the tDCS electrodes to the right hemisphere of the frontal lobe of participants while they viewed arousing pictures (from the International Affective Picture Scale), which accords with the hypothesis. The third part gives a working outline for a potential new study to establish the hypothesis of frontal lobe interhemispheric inhibition failure in bipolar disorder. This study would use a new functional brain imaging technology based on qEEG: standardized weighted low-resolution electromagnetic tomography (swLORETA). If successful, this study may lead to electrical-stimulation therapy for bipolar disorder patients.info:eu-repo/semantics/openAccessUniversidad de Tarapacá. Escuela de Psicología y FilosofíaLímite (Arica) v.13 n.43 20182018-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-50652018000300080es10.4067/S0718-50652018000300080
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Neurociencia trastorno bipolar estimulación de corriente continua transcraneal tomografía electro magnética ponderada estandarizada de baja resolución
spellingShingle	Neurociencia trastorno bipolar estimulación de corriente continua transcraneal tomografía electro magnética ponderada estandarizada de baja resolución Munévar,Gonzalo Shaver,Alyssa Cole,Matthew BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION
description	ABSTRACT This paper has three parts. In the first part we introduce G. Munévar's hypothesis about the neuroscience of bipolar disorder. According to this hypothesis, bipolar disorder is a failure of interhemispheric inhibition in the frontal lobe. When the electrical activation of the left side overwhelms that of the right, the left frontal lobe dominates, thus leading to exaggerated states of ela tion (or others that also constitute mania). Dominance in activation by the right side, in turn, leads to states of depression. The neuroscience literature already offers a large amount of support for this hypothesis, as we explain. The second part describes our own study using transcranial direct current stimulation (tDCS) to successfully decrease positive moods in 25 healthy individuals. This result was obtained by connecting the tDCS electrodes to the right hemisphere of the frontal lobe of participants while they viewed arousing pictures (from the International Affective Picture Scale), which accords with the hypothesis. The third part gives a working outline for a potential new study to establish the hypothesis of frontal lobe interhemispheric inhibition failure in bipolar disorder. This study would use a new functional brain imaging technology based on qEEG: standardized weighted low-resolution electromagnetic tomography (swLORETA). If successful, this study may lead to electrical-stimulation therapy for bipolar disorder patients.
author	Munévar,Gonzalo Shaver,Alyssa Cole,Matthew
author_facet	Munévar,Gonzalo Shaver,Alyssa Cole,Matthew
author_sort	Munévar,Gonzalo
title	BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION
title_short	BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION
title_full	BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION
title_fullStr	BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION
title_full_unstemmed	BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION
title_sort	bipolar disorder as failure of interhemispheric inhibition
publisher	Universidad de Tarapacá. Escuela de Psicología y Filosofía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-50652018000300080
work_keys_str_mv	AT munevargonzalo bipolardisorderasfailureofinterhemisphericinhibition AT shaveralyssa bipolardisorderasfailureofinterhemisphericinhibition AT colematthew bipolardisorderasfailureofinterhemisphericinhibition
_version_	1714204875021090816

BIPOLAR DISORDER AS FAILURE OF INTERHEMISPHERIC INHIBITION

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