Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)

ABSTRACT Prolonged stress hampers immune function and lessens disease resistance of fish, causing economic losses. Attention is thus been centered in the study of fish immunology. The main ‘in vivoʼ models used in immunological studies are: stimulation of immune response (by immun...

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Autores principales:	Sabioni,Rafael Estevan, Lorenz,Evandro Kleber, Cyrino,José Eurico Possebon
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del Mar 2017
Materias:	Piaractus mesopotamicus homeostasis immunomodulation inflammation leukocytes stress lymphocytes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2017000400828
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spelling	oai:scielo:S0718-560X20170004008282017-10-11Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)Sabioni,Rafael EstevanLorenz,Evandro KleberCyrino,José Eurico Possebon Piaractus mesopotamicus homeostasis immunomodulation inflammation leukocytes stress lymphocytes ABSTRACT Prolonged stress hampers immune function and lessens disease resistance of fish, causing economic losses. Attention is thus been centered in the study of fish immunology. The main ‘in vivoʼ models used in immunological studies are: stimulation of immune response (by immunostimulant molecules); induction of inflammation; induction of immunosuppression by chronic stress; or administration of drugs. This trial aimed at evaluating existing protocols for immunosuppression by drugs in fish, adapted to slow release implants model, using hydrogenated vegetable fat (HVF), with the intention of set a controlled immunodeficiency state model for advanced studies. The implant model was not efficient in reducing the immune response in a controlled manner. Evidence of self, down-regulation in fish immune system was found in implanted fish, what should be further investigated using molecular tools.info:eu-repo/semantics/openAccessPontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del MarLatin american journal of aquatic research v.45 n.4 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2017000400828en10.3856/vol45-issue4-fulltext-19
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Piaractus mesopotamicus homeostasis immunomodulation inflammation leukocytes stress lymphocytes
spellingShingle	Piaractus mesopotamicus homeostasis immunomodulation inflammation leukocytes stress lymphocytes Sabioni,Rafael Estevan Lorenz,Evandro Kleber Cyrino,José Eurico Possebon Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)
description	ABSTRACT Prolonged stress hampers immune function and lessens disease resistance of fish, causing economic losses. Attention is thus been centered in the study of fish immunology. The main ‘in vivoʼ models used in immunological studies are: stimulation of immune response (by immunostimulant molecules); induction of inflammation; induction of immunosuppression by chronic stress; or administration of drugs. This trial aimed at evaluating existing protocols for immunosuppression by drugs in fish, adapted to slow release implants model, using hydrogenated vegetable fat (HVF), with the intention of set a controlled immunodeficiency state model for advanced studies. The implant model was not efficient in reducing the immune response in a controlled manner. Evidence of self, down-regulation in fish immune system was found in implanted fish, what should be further investigated using molecular tools.
author	Sabioni,Rafael Estevan Lorenz,Evandro Kleber Cyrino,José Eurico Possebon
author_facet	Sabioni,Rafael Estevan Lorenz,Evandro Kleber Cyrino,José Eurico Possebon
author_sort	Sabioni,Rafael Estevan
title	Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)
title_short	Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)
title_full	Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)
title_fullStr	Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)
title_full_unstemmed	Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)
title_sort	preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (piaractus mesopotamicus)
publisher	Pontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del Mar
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2017000400828
work_keys_str_mv	AT sabionirafaelestevan preliminaryassessmentofslowreleaseimplantmodelforimmunosuppressioninjuvenilepacupiaractusmesopotamicus AT lorenzevandrokleber preliminaryassessmentofslowreleaseimplantmodelforimmunosuppressioninjuvenilepacupiaractusmesopotamicus AT cyrinojoseeuricopossebon preliminaryassessmentofslowreleaseimplantmodelforimmunosuppressioninjuvenilepacupiaractusmesopotamicus
_version_	1714205187720085504

Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)

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