Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts

ABSTRACT This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi. The antioxidant capacity of these extra...

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Autores principales:	Miranda-Delgado,Alejandra, Montoya,María José, Paz-Araos,Marilyn, Mellado,Marco, Villena,Joan, Arancibia,Paulina, Madrid,Alejandro, Jara-Gutiérrez,Carlos
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del Mar 2018
Materias:	algae antioxidant activity cytotoxicity cancer polyphenols flavonoids Chilean coast
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2018000200301
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spelling	oai:scielo:S0718-560X20180002003012018-06-13Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coastsMiranda-Delgado,AlejandraMontoya,María JoséPaz-Araos,MarilynMellado,MarcoVillena,JoanArancibia,PaulinaMadrid,AlejandroJara-Gutiérrez,Carlos algae antioxidant activity cytotoxicity cancer polyphenols flavonoids Chilean coast ABSTRACT This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi. The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays. Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN). The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of this D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective. Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.info:eu-repo/semantics/openAccessPontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del MarLatin american journal of aquatic research v.46 n.2 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2018000200301en10.3856/vol46-issue2-fulltext-6
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	algae antioxidant activity cytotoxicity cancer polyphenols flavonoids Chilean coast
spellingShingle	algae antioxidant activity cytotoxicity cancer polyphenols flavonoids Chilean coast Miranda-Delgado,Alejandra Montoya,María José Paz-Araos,Marilyn Mellado,Marco Villena,Joan Arancibia,Paulina Madrid,Alejandro Jara-Gutiérrez,Carlos Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts
description	ABSTRACT This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi. The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays. Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN). The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of this D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective. Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.
author	Miranda-Delgado,Alejandra Montoya,María José Paz-Araos,Marilyn Mellado,Marco Villena,Joan Arancibia,Paulina Madrid,Alejandro Jara-Gutiérrez,Carlos
author_facet	Miranda-Delgado,Alejandra Montoya,María José Paz-Araos,Marilyn Mellado,Marco Villena,Joan Arancibia,Paulina Madrid,Alejandro Jara-Gutiérrez,Carlos
author_sort	Miranda-Delgado,Alejandra
title	Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts
title_short	Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts
title_full	Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts
title_fullStr	Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts
title_full_unstemmed	Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts
title_sort	antioxidant and anti-cancer activities of brown and red seaweed extracts from chilean coasts
publisher	Pontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del Mar
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2018000200301
work_keys_str_mv	AT mirandadelgadoalejandra antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts AT montoyamariajose antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts AT pazaraosmarilyn antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts AT melladomarco antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts AT villenajoan antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts AT arancibiapaulina antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts AT madridalejandro antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts AT jaragutierrezcarlos antioxidantandanticanceractivitiesofbrownandredseaweedextractsfromchileancoasts
_version_	1714205198192214016

Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts

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