Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium

ABSTRACT Chromium (Cr) is an element present in nature in mineral form. It has a dual effect, both as an essential micronutrient and a carcinogenic agent depending on its chemical form and concentration. It is present in various environmental matrices such as water, soil, and air, coming from natura...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sánchez-Olivares,Marco Antonio, Gaytán-Oyarzun,Juan Carlos, Gordillo-Martínez,Alberto José, Prieto-Garcia,Francisco, Cabrera-Cruz,René Bernardo Elías
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del Mar 2021
Materias:	Danio rerio embryos malformations chromium teratogenicity embryonic development
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2021000200289
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0718-560X2021000200289
record_format	dspace
spelling	oai:scielo:S0718-560X20210002002892021-06-10Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromiumSánchez-Olivares,Marco AntonioGaytán-Oyarzun,Juan CarlosGordillo-Martínez,Alberto JoséPrieto-Garcia,FranciscoCabrera-Cruz,René Bernardo Elías Danio rerio embryos malformations chromium teratogenicity embryonic development ABSTRACT Chromium (Cr) is an element present in nature in mineral form. It has a dual effect, both as an essential micronutrient and a carcinogenic agent depending on its chemical form and concentration. It is present in various environmental matrices such as water, soil, and air, coming from natural and anthropogenic sources, and causes harmful effects on biota, ecosystems, and even human beings. This study's objective was to evaluate chromium toxicity and teratogenicity in zebrafish embryos of Danio rerio exposed to chromium through the D. rerio teratology assay (DarTA) test by evaluating spine malformations. To this end, the chromium toxicity curve was calculated from zebrafish embryos exposed to potassium dichromate (K2Cr2O7), and the probit test was used to establish the mean lethal concentration (LC50) and three subtoxic concentrations LC25, LC12.5, and LC6.25 to evaluate the teratogenicity. The results showed that potassium dichromate was statistically positive for the teratogenic effect at the three highest concentrations evaluated. Potassium dichromate exposure causes abnormal embryonic development and teratogenic effects, including severe heart defects in zebrafish embryos. Therefore, we conclude that potassium dichromate is toxic to the zebrafish developmental stages. The finding that potassium dichromate is teratogenic in zebrafish embryos suggests that this metal should be tested and evaluate potential risk in mammalian systems.info:eu-repo/semantics/openAccessPontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del MarLatin american journal of aquatic research v.49 n.2 20212021-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2021000200289en10.3856/vol49-issue2-fulltext-2561
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Danio rerio embryos malformations chromium teratogenicity embryonic development
spellingShingle	Danio rerio embryos malformations chromium teratogenicity embryonic development Sánchez-Olivares,Marco Antonio Gaytán-Oyarzun,Juan Carlos Gordillo-Martínez,Alberto José Prieto-Garcia,Francisco Cabrera-Cruz,René Bernardo Elías Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium
description	ABSTRACT Chromium (Cr) is an element present in nature in mineral form. It has a dual effect, both as an essential micronutrient and a carcinogenic agent depending on its chemical form and concentration. It is present in various environmental matrices such as water, soil, and air, coming from natural and anthropogenic sources, and causes harmful effects on biota, ecosystems, and even human beings. This study's objective was to evaluate chromium toxicity and teratogenicity in zebrafish embryos of Danio rerio exposed to chromium through the D. rerio teratology assay (DarTA) test by evaluating spine malformations. To this end, the chromium toxicity curve was calculated from zebrafish embryos exposed to potassium dichromate (K2Cr2O7), and the probit test was used to establish the mean lethal concentration (LC50) and three subtoxic concentrations LC25, LC12.5, and LC6.25 to evaluate the teratogenicity. The results showed that potassium dichromate was statistically positive for the teratogenic effect at the three highest concentrations evaluated. Potassium dichromate exposure causes abnormal embryonic development and teratogenic effects, including severe heart defects in zebrafish embryos. Therefore, we conclude that potassium dichromate is toxic to the zebrafish developmental stages. The finding that potassium dichromate is teratogenic in zebrafish embryos suggests that this metal should be tested and evaluate potential risk in mammalian systems.
author	Sánchez-Olivares,Marco Antonio Gaytán-Oyarzun,Juan Carlos Gordillo-Martínez,Alberto José Prieto-Garcia,Francisco Cabrera-Cruz,René Bernardo Elías
author_facet	Sánchez-Olivares,Marco Antonio Gaytán-Oyarzun,Juan Carlos Gordillo-Martínez,Alberto José Prieto-Garcia,Francisco Cabrera-Cruz,René Bernardo Elías
author_sort	Sánchez-Olivares,Marco Antonio
title	Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium
title_short	Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium
title_full	Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium
title_fullStr	Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium
title_full_unstemmed	Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium
title_sort	toxicity and teratogenicity in zebrafish danio rerio embryos exposed to chromium
publisher	Pontificia Universidad Católica de Valparaíso. Facultad de Recursos Naturales. Escuela de Ciencias del Mar
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-560X2021000200289
work_keys_str_mv	AT sanchezolivaresmarcoantonio toxicityandteratogenicityinzebrafishdaniorerioembryosexposedtochromium AT gaytanoyarzunjuancarlos toxicityandteratogenicityinzebrafishdaniorerioembryosexposedtochromium AT gordillomartinezalbertojose toxicityandteratogenicityinzebrafishdaniorerioembryosexposedtochromium AT prietogarciafrancisco toxicityandteratogenicityinzebrafishdaniorerioembryosexposedtochromium AT cabreracruzrenebernardoelias toxicityandteratogenicityinzebrafishdaniorerioembryosexposedtochromium
_version_	1714205249031372800

Toxicity and teratogenicity in zebrafish Danio rerio embryos exposed to chromium

Ejemplares similares