E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma

Objective: The aim of this study was to assess epithelial expression of E-cadherin and c-Met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. Study Design: Biopsies of normal lip vermillion (NL, n=18), actinic cheilitis (AC, n=37), and lip SCC (n=22) were processed for E-cadherin...

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Autores principales:	Martínez,A, Spencer,ML, Borlando,J, Flores,M, Rojas,IG
Lenguaje:	English
Publicado:	Sociedad de Periodoncia de Chile. Sociedad de Implantología Oral de Chile. Sociedad de Prótesis y Rehabilitación Oral de Chile. 2011
Materias:	E-cadherin c-Met lip carcinogenesis UV light actinic cheilitis lip squamous cell carcinoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-01072011000300008
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spelling	oai:scielo:S0719-010720110003000082012-01-24E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinomaMartínez,ASpencer,MLBorlando,JFlores,MRojas,IG E-cadherin c-Met lip carcinogenesis UV light actinic cheilitis lip squamous cell carcinoma Objective: The aim of this study was to assess epithelial expression of E-cadherin and c-Met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. Study Design: Biopsies of normal lip vermillion (NL, n=18), actinic cheilitis (AC, n=37), and lip SCC (n=22) were processed for E-cadherin and c-Met immunodetection. Epithelial and tumor cell expression was scored for each sample considering staining intensity and percentage. Results: E-cadherin expression was significantly reduced in AC and lip SCC as compared to normal lip (P<0.05), with a significant reduction in lip SCC as compared to AC (P=0.003). Expression of c-Met was significantly higher in AC and lip SCC as compared to NL (P<0.05), with a significant increase in lip SCC as compared to AC (P<0.0001). Conclusion: The results showed that epithelial E-cadherin expression is reduced and c-Met expression is increased as lip carcinogenesis progresses, suggesting that these proteins may be useful markers of malignant transformation.info:eu-repo/semantics/openAccessSociedad de Periodoncia de Chile. Sociedad de Implantología Oral de Chile. Sociedad de Prótesis y Rehabilitación Oral de Chile.Revista clínica de periodoncia, implantología y rehabilitación oral v.4 n.3 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-01072011000300008en10.4067/S0719-01072011000300008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	E-cadherin c-Met lip carcinogenesis UV light actinic cheilitis lip squamous cell carcinoma
spellingShingle	E-cadherin c-Met lip carcinogenesis UV light actinic cheilitis lip squamous cell carcinoma Martínez,A Spencer,ML Borlando,J Flores,M Rojas,IG E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
description	Objective: The aim of this study was to assess epithelial expression of E-cadherin and c-Met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. Study Design: Biopsies of normal lip vermillion (NL, n=18), actinic cheilitis (AC, n=37), and lip SCC (n=22) were processed for E-cadherin and c-Met immunodetection. Epithelial and tumor cell expression was scored for each sample considering staining intensity and percentage. Results: E-cadherin expression was significantly reduced in AC and lip SCC as compared to normal lip (P<0.05), with a significant reduction in lip SCC as compared to AC (P=0.003). Expression of c-Met was significantly higher in AC and lip SCC as compared to NL (P<0.05), with a significant increase in lip SCC as compared to AC (P<0.0001). Conclusion: The results showed that epithelial E-cadherin expression is reduced and c-Met expression is increased as lip carcinogenesis progresses, suggesting that these proteins may be useful markers of malignant transformation.
author	Martínez,A Spencer,ML Borlando,J Flores,M Rojas,IG
author_facet	Martínez,A Spencer,ML Borlando,J Flores,M Rojas,IG
author_sort	Martínez,A
title	E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
title_short	E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
title_full	E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
title_fullStr	E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
title_full_unstemmed	E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
title_sort	e-cadherin and c-met expression in actinic cheilits and lip squamous cell carcinoma
publisher	Sociedad de Periodoncia de Chile. Sociedad de Implantología Oral de Chile. Sociedad de Prótesis y Rehabilitación Oral de Chile.
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-01072011000300008
work_keys_str_mv	AT martineza ecadherinandcmetexpressioninactiniccheilitsandlipsquamouscellcarcinoma AT spencerml ecadherinandcmetexpressioninactiniccheilitsandlipsquamouscellcarcinoma AT borlandoj ecadherinandcmetexpressioninactiniccheilitsandlipsquamouscellcarcinoma AT floresm ecadherinandcmetexpressioninactiniccheilitsandlipsquamouscellcarcinoma AT rojasig ecadherinandcmetexpressioninactiniccheilitsandlipsquamouscellcarcinoma
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E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma

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