Association between the use of statins and periodontal status: a review

ABSTRACT: Background: Statins are drugs used for the treatment of dyslipidemia. However, statins have multiple actions, including anti-inflammatory and immunomodulatory effects, as well as the ability to stimulate new bone formation. Such features could be beneficial for periodontal pathology ther...

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Autores principales:	Rosenberg,David R, Vega,María Paz, Chaparro,Alejandra, Kernitsky,Jeremy R, Andrade,Catherine X, Violant,Déborah, Nart,José
Lenguaje:	English
Publicado:	Sociedad de Periodoncia de Chile. Sociedad de Implantología Oral de Chile. Sociedad de Prótesis y Rehabilitación Oral de Chile. 2019
Materias:	Statins Periodontitis Drug delivery Drugs and periodontium
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-01072019000100041
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spelling	oai:scielo:S0719-010720190001000412019-04-11Association between the use of statins and periodontal status: a reviewRosenberg,David RVega,María PazChaparro,AlejandraKernitsky,Jeremy RAndrade,Catherine XViolant,DéborahNart,José Statins Periodontitis Drug delivery Drugs and periodontium ABSTRACT: Background: Statins are drugs used for the treatment of dyslipidemia. However, statins have multiple actions, including anti-inflammatory and immunomodulatory effects, as well as the ability to stimulate new bone formation. Such features could be beneficial for periodontal pathology therapy. Methods: A literature review was conducted using filtered electronic databases (Cochrane and Trip) and unfiltered databases (Medline/PubMed, Scielo and Google Scholar). The articles chosen were controlled and randomized clinical trials that performed local delivery of statins to humans and assessed the effects of immunomodulation and bone regeneration on periodontal disease between 2010 and 2017. All of the studies were blind or double-blind and were written in English. Results: The inclusion criteria were applied to a total of 79 identified articles, and 10 studies were ultimately chosen. The results show that an injected dose of statins or the local delivery of atorvastatin (ATV) leads to a significant improvement in clinical and radiographic periodontal parameters. Moreover, rosuvastatin (RSV) induced stronger beneficial effects when administered systemically, whereas ATV and simvastatin (SMV) had better results following topical delivery. Conclusions: Statins can affect periodontal status, increasing the gain in clinical attachment and decreasing gingival bleeding, probing depth and the magnitude of bone defects. For this reason, statins represent an excellent support measure for conventional periodontal therapy. Specifically, positive effects are seen for local delivery of statins as an adjunct treatment to scaling and root planing (SRP) at doses of 1.2 to 2%. Statins could be administered through topical delivery via direct injection in the periodontal pocket or by brushing with medicated dentifrices. More studies with appropriate designs should evaluate the short and long term clinical benefit of statins inpatients with periodontal pathology. These studies should determine the appropriate dose, timing side effects and ideal vehicles for delivery.info:eu-repo/semantics/openAccessSociedad de Periodoncia de Chile. Sociedad de Implantología Oral de Chile. Sociedad de Prótesis y Rehabilitación Oral de Chile.Revista clínica de periodoncia, implantología y rehabilitación oral v.12 n.1 20192019-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-01072019000100041en10.4067/S0719-01072019000100041
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Statins Periodontitis Drug delivery Drugs and periodontium
spellingShingle	Statins Periodontitis Drug delivery Drugs and periodontium Rosenberg,David R Vega,María Paz Chaparro,Alejandra Kernitsky,Jeremy R Andrade,Catherine X Violant,Déborah Nart,José Association between the use of statins and periodontal status: a review
description	ABSTRACT: Background: Statins are drugs used for the treatment of dyslipidemia. However, statins have multiple actions, including anti-inflammatory and immunomodulatory effects, as well as the ability to stimulate new bone formation. Such features could be beneficial for periodontal pathology therapy. Methods: A literature review was conducted using filtered electronic databases (Cochrane and Trip) and unfiltered databases (Medline/PubMed, Scielo and Google Scholar). The articles chosen were controlled and randomized clinical trials that performed local delivery of statins to humans and assessed the effects of immunomodulation and bone regeneration on periodontal disease between 2010 and 2017. All of the studies were blind or double-blind and were written in English. Results: The inclusion criteria were applied to a total of 79 identified articles, and 10 studies were ultimately chosen. The results show that an injected dose of statins or the local delivery of atorvastatin (ATV) leads to a significant improvement in clinical and radiographic periodontal parameters. Moreover, rosuvastatin (RSV) induced stronger beneficial effects when administered systemically, whereas ATV and simvastatin (SMV) had better results following topical delivery. Conclusions: Statins can affect periodontal status, increasing the gain in clinical attachment and decreasing gingival bleeding, probing depth and the magnitude of bone defects. For this reason, statins represent an excellent support measure for conventional periodontal therapy. Specifically, positive effects are seen for local delivery of statins as an adjunct treatment to scaling and root planing (SRP) at doses of 1.2 to 2%. Statins could be administered through topical delivery via direct injection in the periodontal pocket or by brushing with medicated dentifrices. More studies with appropriate designs should evaluate the short and long term clinical benefit of statins inpatients with periodontal pathology. These studies should determine the appropriate dose, timing side effects and ideal vehicles for delivery.
author	Rosenberg,David R Vega,María Paz Chaparro,Alejandra Kernitsky,Jeremy R Andrade,Catherine X Violant,Déborah Nart,José
author_facet	Rosenberg,David R Vega,María Paz Chaparro,Alejandra Kernitsky,Jeremy R Andrade,Catherine X Violant,Déborah Nart,José
author_sort	Rosenberg,David R
title	Association between the use of statins and periodontal status: a review
title_short	Association between the use of statins and periodontal status: a review
title_full	Association between the use of statins and periodontal status: a review
title_fullStr	Association between the use of statins and periodontal status: a review
title_full_unstemmed	Association between the use of statins and periodontal status: a review
title_sort	association between the use of statins and periodontal status: a review
publisher	Sociedad de Periodoncia de Chile. Sociedad de Implantología Oral de Chile. Sociedad de Prótesis y Rehabilitación Oral de Chile.
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-01072019000100041
work_keys_str_mv	AT rosenbergdavidr associationbetweentheuseofstatinsandperiodontalstatusareview AT vegamariapaz associationbetweentheuseofstatinsandperiodontalstatusareview AT chaparroalejandra associationbetweentheuseofstatinsandperiodontalstatusareview AT kernitskyjeremyr associationbetweentheuseofstatinsandperiodontalstatusareview AT andradecatherinex associationbetweentheuseofstatinsandperiodontalstatusareview AT violantdeborah associationbetweentheuseofstatinsandperiodontalstatusareview AT nartjose associationbetweentheuseofstatinsandperiodontalstatusareview
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Association between the use of statins and periodontal status: a review

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