Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia

ABSTRACT: The aim of this study was to examine the clinical presentation, biochemical profile and response to treatment among horses with experimentally-induced hypocalcemia. Twelve adult, mixed breed mares were used. A 5% ethylenediaminetetraacetic acid disodium (Na2EDTA) solution was infused into...

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Autores principales:	Barrêto-Júnior,Raimundo A., Minervino,Antonio H., Rodrigues,Federico A., Meira Júnior,Enoch B., Lima,Alessandra, Sousa,Rejane, Mori,Clara, Araújo,Carolina A., R.Fernandes,Wilson, Ortolani,Enrico
Lenguaje:	English
Publicado:	Universidad Austral de Chile. Facultad de Ciencias Veterinarias 2017
Materias:	calcium phosphorus treatment Na2EDTA
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322017000100103
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spelling	oai:scielo:S0719-813220170001001032019-11-28Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemiaBarrêto-Júnior,Raimundo A.Minervino,Antonio H.Rodrigues,Federico A.Meira Júnior,Enoch B.Lima,AlessandraSousa,RejaneMori,ClaraAraújo,Carolina A.R.Fernandes,WilsonOrtolani,Enrico calcium phosphorus treatment Na2EDTA ABSTRACT: The aim of this study was to examine the clinical presentation, biochemical profile and response to treatment among horses with experimentally-induced hypocalcemia. Twelve adult, mixed breed mares were used. A 5% ethylenediaminetetraacetic acid disodium (Na2EDTA) solution was infused into all the mares until the animals presented clinical signs of hypocalcemia, at which point they were divided into a control group (n = 5) and a treatment group (n = 7). The treated group received an infusion of calcium, phosphorus, magnesium and glucose at a dosage of 1 mL/kg/BW during 30 minutes. The control group received 0.9% saline solution at the same dosage. Clinical examination and blood sample collection were performed at the times T0 (baseline- thirty minutes before beginning the Na2EDTA), T1 (at the end of the Na2EDTA infusion), T2 (at the end of the treatment) and T3 (24 hours after the end of the experiment). Serum calcium and magnesium concentrations decreased in response to Na2EDTA administration. The clinical signs of hypocalcemia in the mares included tachycardia, tachypnea, hypophonesis and cecal atony. These signs disappeared over the course of treatment, while total calcium and magnesium increased. Treatment produced recovery from clinical hypocalcemia within 30 minutes and promoted return of the main biochemical parameters to baseline values.info:eu-repo/semantics/openAccessUniversidad Austral de Chile. Facultad de Ciencias VeterinariasAustral journal of veterinary sciences v.49 n.1 20172017-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322017000100103en10.4067/s0719-81322017000100009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	calcium phosphorus treatment Na2EDTA
spellingShingle	calcium phosphorus treatment Na2EDTA Barrêto-Júnior,Raimundo A. Minervino,Antonio H. Rodrigues,Federico A. Meira Júnior,Enoch B. Lima,Alessandra Sousa,Rejane Mori,Clara Araújo,Carolina A. R.Fernandes,Wilson Ortolani,Enrico Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia
description	ABSTRACT: The aim of this study was to examine the clinical presentation, biochemical profile and response to treatment among horses with experimentally-induced hypocalcemia. Twelve adult, mixed breed mares were used. A 5% ethylenediaminetetraacetic acid disodium (Na2EDTA) solution was infused into all the mares until the animals presented clinical signs of hypocalcemia, at which point they were divided into a control group (n = 5) and a treatment group (n = 7). The treated group received an infusion of calcium, phosphorus, magnesium and glucose at a dosage of 1 mL/kg/BW during 30 minutes. The control group received 0.9% saline solution at the same dosage. Clinical examination and blood sample collection were performed at the times T0 (baseline- thirty minutes before beginning the Na2EDTA), T1 (at the end of the Na2EDTA infusion), T2 (at the end of the treatment) and T3 (24 hours after the end of the experiment). Serum calcium and magnesium concentrations decreased in response to Na2EDTA administration. The clinical signs of hypocalcemia in the mares included tachycardia, tachypnea, hypophonesis and cecal atony. These signs disappeared over the course of treatment, while total calcium and magnesium increased. Treatment produced recovery from clinical hypocalcemia within 30 minutes and promoted return of the main biochemical parameters to baseline values.
author	Barrêto-Júnior,Raimundo A. Minervino,Antonio H. Rodrigues,Federico A. Meira Júnior,Enoch B. Lima,Alessandra Sousa,Rejane Mori,Clara Araújo,Carolina A. R.Fernandes,Wilson Ortolani,Enrico
author_facet	Barrêto-Júnior,Raimundo A. Minervino,Antonio H. Rodrigues,Federico A. Meira Júnior,Enoch B. Lima,Alessandra Sousa,Rejane Mori,Clara Araújo,Carolina A. R.Fernandes,Wilson Ortolani,Enrico
author_sort	Barrêto-Júnior,Raimundo A.
title	Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia
title_short	Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia
title_full	Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia
title_fullStr	Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia
title_full_unstemmed	Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia
title_sort	clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia
publisher	Universidad Austral de Chile. Facultad de Ciencias Veterinarias
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322017000100103
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Clinical presentation and biochemical profile of horses during induction and treatment of hypocalcemia

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