IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation

ABSTRACT: Environmental cues influence growth and development of mammals during prenatal and particularly early postnatal life and can exert long-lasting effects in adult life. High circulating concentration of glucocorticoids during pregnancy (prenatal stress) affects the activity of the hypothalam...

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Autores principales:	Falcone,Eliana G., Liaudat,Ana C., Alustiza,Fabrisio E., Mayer,Nora, Bosch,Pablo, Vivas,Adriana, Gauna,Hector, Rodríguez,Nancy
Lenguaje:	English
Publicado:	Universidad Austral de Chile. Facultad de Ciencias Veterinarias 2017
Materias:	early stimulation prenatal stress hypothalamic-pituitary-adrenal axis immune system
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322017000200113
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spelling	oai:scielo:S0719-813220170002001132017-11-14IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulationFalcone,Eliana G.Liaudat,Ana C.Alustiza,Fabrisio E.Mayer,NoraBosch,PabloVivas,AdrianaGauna,HectorRodríguez,Nancy early stimulation prenatal stress hypothalamic-pituitary-adrenal axis immune system ABSTRACT: Environmental cues influence growth and development of mammals during prenatal and particularly early postnatal life and can exert long-lasting effects in adult life. High circulating concentration of glucocorticoids during pregnancy (prenatal stress) affects the activity of the hypothalamic-pituitary-adrenal axis (HPA) of offspring and has been linked to alter immune system responses. Early postnatal stimulation (handling) of prenatally stressed animals generates long-term beneficial effects on the reactiveness of the HPA axis and immune system function. The aim of this study was to further investigate the effect of handling on immune response in prenatally stressed male rats and to elucidate a possible relationship with the HPA axis activity. Control and prenatally stressed (PS) offspring by immobilization (IMO) were handled during the first week of life. Animals from both treatments were subjected to acute stress by IMO. Corticosterone (COR) plasma concentration was measured by RIA assay, T lymphocyte proliferation by [3H] thymidine assay and IL-2 levels by direct ELISA technique. Chronic IMO prenatal stress caused an increase in mother plasma COR basal levels. Furthermore, prenatally stressed rats subjected to an acute stress session had lower T cell proliferation and decreased IL-2 release. In addition, early postnatal stimulation reversed the negative effects of prenatal stress on proliferation of T lymphocytes and IL-2 release.info:eu-repo/semantics/openAccessUniversidad Austral de Chile. Facultad de Ciencias VeterinariasAustral journal of veterinary sciences v.49 n.2 20172017-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322017000200113en10.4067/S0719-81322017000200113
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	early stimulation prenatal stress hypothalamic-pituitary-adrenal axis immune system
spellingShingle	early stimulation prenatal stress hypothalamic-pituitary-adrenal axis immune system Falcone,Eliana G. Liaudat,Ana C. Alustiza,Fabrisio E. Mayer,Nora Bosch,Pablo Vivas,Adriana Gauna,Hector Rodríguez,Nancy IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation
description	ABSTRACT: Environmental cues influence growth and development of mammals during prenatal and particularly early postnatal life and can exert long-lasting effects in adult life. High circulating concentration of glucocorticoids during pregnancy (prenatal stress) affects the activity of the hypothalamic-pituitary-adrenal axis (HPA) of offspring and has been linked to alter immune system responses. Early postnatal stimulation (handling) of prenatally stressed animals generates long-term beneficial effects on the reactiveness of the HPA axis and immune system function. The aim of this study was to further investigate the effect of handling on immune response in prenatally stressed male rats and to elucidate a possible relationship with the HPA axis activity. Control and prenatally stressed (PS) offspring by immobilization (IMO) were handled during the first week of life. Animals from both treatments were subjected to acute stress by IMO. Corticosterone (COR) plasma concentration was measured by RIA assay, T lymphocyte proliferation by [3H] thymidine assay and IL-2 levels by direct ELISA technique. Chronic IMO prenatal stress caused an increase in mother plasma COR basal levels. Furthermore, prenatally stressed rats subjected to an acute stress session had lower T cell proliferation and decreased IL-2 release. In addition, early postnatal stimulation reversed the negative effects of prenatal stress on proliferation of T lymphocytes and IL-2 release.
author	Falcone,Eliana G. Liaudat,Ana C. Alustiza,Fabrisio E. Mayer,Nora Bosch,Pablo Vivas,Adriana Gauna,Hector Rodríguez,Nancy
author_facet	Falcone,Eliana G. Liaudat,Ana C. Alustiza,Fabrisio E. Mayer,Nora Bosch,Pablo Vivas,Adriana Gauna,Hector Rodríguez,Nancy
author_sort	Falcone,Eliana G.
title	IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation
title_short	IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation
title_full	IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation
title_fullStr	IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation
title_full_unstemmed	IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation
title_sort	il-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation
publisher	Universidad Austral de Chile. Facultad de Ciencias Veterinarias
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322017000200113
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IL-2 is involved in immune response of prenatally stressed rats exposed to postnatally stimulation

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