Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations

Abstract: Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical f...

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Autores principales:	Auad,Jordana, Cerutti,Julieta, Cooper,Laura G., Camussone,Cecilia M., Lozano,Natalia A., Crespo,Francisco M., Lozano,Alejandro
Lenguaje:	English
Publicado:	Universidad Austral de Chile. Facultad de Ciencias Veterinarias 2018
Materias:	ISPA adjuvant immunoglobulin G colostrum
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322018000200101
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spelling	oai:scielo:S0719-813220180002001012018-05-23Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulationsAuad,JordanaCerutti,JulietaCooper,Laura G.Camussone,Cecilia M.Lozano,Natalia A.Crespo,Francisco M.Lozano,Alejandro ISPA adjuvant immunoglobulin G colostrum Abstract: Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.info:eu-repo/semantics/openAccessUniversidad Austral de Chile. Facultad de Ciencias VeterinariasAustral journal of veterinary sciences v.50 n.2 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322018000200101en10.4067/S0719-81322018000200101
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	ISPA adjuvant immunoglobulin G colostrum
spellingShingle	ISPA adjuvant immunoglobulin G colostrum Auad,Jordana Cerutti,Julieta Cooper,Laura G. Camussone,Cecilia M. Lozano,Natalia A. Crespo,Francisco M. Lozano,Alejandro Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
description	Abstract: Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.
author	Auad,Jordana Cerutti,Julieta Cooper,Laura G. Camussone,Cecilia M. Lozano,Natalia A. Crespo,Francisco M. Lozano,Alejandro
author_facet	Auad,Jordana Cerutti,Julieta Cooper,Laura G. Camussone,Cecilia M. Lozano,Natalia A. Crespo,Francisco M. Lozano,Alejandro
author_sort	Auad,Jordana
title	Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_short	Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_full	Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_fullStr	Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_full_unstemmed	Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_sort	humoral immune response of pregnant goats to two corynebacterium pseudotuberculosis bacterin formulations
publisher	Universidad Austral de Chile. Facultad de Ciencias Veterinarias
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322018000200101
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Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations

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