Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?

ABSTRACT Despite the vast amount of molecular data obtained from classical pain studies, there is an ongoing translational pain model crisis reflected by the reduced amount of new effective and safe compounds developed to treat chronic pain in humans. Naturally occurring chronic pain in animals may...

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Autores principales: Herzberg,Daniel E., Bustamante,Hedie A.
Lenguaje:English
Publicado: Universidad Austral de Chile. Facultad de Ciencias Veterinarias 2021
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322021000100047
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spelling oai:scielo:S0719-813220210001000472021-02-07Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?Herzberg,Daniel E.Bustamante,Hedie A. chronic pain animal models translational ABSTRACT Despite the vast amount of molecular data obtained from classical pain studies, there is an ongoing translational pain model crisis reflected by the reduced amount of new effective and safe compounds developed to treat chronic pain in humans. Naturally occurring chronic pain in animals may offer some advantages over induced models of chronic pain, including a natural development of the condition that induces pain, the heterogenicity of the population that affects, and the chronologic age in which they develop, among others. The identification and study of naturally occurring painful diseases that resemble a particular chronic painful condition in humans has been proposed as a potential tool to investigate the molecular mechanisms and thus, accelerating drug development at the preclinical and clinical level. Currently, certain types of chronic pain in companion and large animals have gained attention as potential translational models of chronic pain. Examples of these include canine and feline osteoarthritis, neoplastic diseases as osteosarcoma and bovine and equine lameness. The present review describes the limitations of animal models of chronic pain and briefly enters in how naturally occurring pain models could represent a translational approach to chronic pain.info:eu-repo/semantics/openAccessUniversidad Austral de Chile. Facultad de Ciencias VeterinariasAustral journal of veterinary sciences v.53 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322021000100047en10.4067/S0719-81322021000100047
institution Scielo Chile
collection Scielo Chile
language English
topic chronic pain
animal models
translational
spellingShingle chronic pain
animal models
translational
Herzberg,Daniel E.
Bustamante,Hedie A.
Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?
description ABSTRACT Despite the vast amount of molecular data obtained from classical pain studies, there is an ongoing translational pain model crisis reflected by the reduced amount of new effective and safe compounds developed to treat chronic pain in humans. Naturally occurring chronic pain in animals may offer some advantages over induced models of chronic pain, including a natural development of the condition that induces pain, the heterogenicity of the population that affects, and the chronologic age in which they develop, among others. The identification and study of naturally occurring painful diseases that resemble a particular chronic painful condition in humans has been proposed as a potential tool to investigate the molecular mechanisms and thus, accelerating drug development at the preclinical and clinical level. Currently, certain types of chronic pain in companion and large animals have gained attention as potential translational models of chronic pain. Examples of these include canine and feline osteoarthritis, neoplastic diseases as osteosarcoma and bovine and equine lameness. The present review describes the limitations of animal models of chronic pain and briefly enters in how naturally occurring pain models could represent a translational approach to chronic pain.
author Herzberg,Daniel E.
Bustamante,Hedie A.
author_facet Herzberg,Daniel E.
Bustamante,Hedie A.
author_sort Herzberg,Daniel E.
title Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?
title_short Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?
title_full Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?
title_fullStr Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?
title_full_unstemmed Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?
title_sort animal models of chronic pain. are naturally occurring diseases a potential model for translational research?
publisher Universidad Austral de Chile. Facultad de Ciencias Veterinarias
publishDate 2021
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322021000100047
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AT bustamantehediea animalmodelsofchronicpainarenaturallyoccurringdiseasesapotentialmodelfortranslationalresearch
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