Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality

ABSTRACT Porcine epidemic diarrhoea (PED) is a disease caused by an alphacoronavirus and the symptoms include watery diarrhoea and vomiting, with more than 80% mortality amongst newborn piglets. The placentation in sows hinders the transference of antibodies to the foetus, therefore, the vaccination...

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Autores principales:	Galindo-Castañeda,Lourdes M., Chacón-Salinas,Rommel, Quintero,Víctor, Sanchez-Betancourt,José I., Cobos-Marín,Laura
Lenguaje:	English
Publicado:	Universidad Austral de Chile. Facultad de Ciencias Veterinarias 2021
Materias:	vaccine PED nulliparous colostrum
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322021000300147
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spelling	oai:scielo:S0719-813220210003001472021-09-15Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortalityGalindo-Castañeda,Lourdes M.Chacón-Salinas,RommelQuintero,VíctorSanchez-Betancourt,José I.Cobos-Marín,Laura vaccine PED nulliparous colostrum ABSTRACT Porcine epidemic diarrhoea (PED) is a disease caused by an alphacoronavirus and the symptoms include watery diarrhoea and vomiting, with more than 80% mortality amongst newborn piglets. The placentation in sows hinders the transference of antibodies to the foetus, therefore, the vaccination of pregnant females and transference of antibodies to piglets through colostrum are essential to protect them against virus particles. The aim of the study was to determine whether vaccination of nulliparous gilts could induce a high colostrum antibody titre and lower litter mortality, in comparison with vaccinated multiparous sows previously exposed to the virus. Samples of colostrum were obtained from 11 nulliparous gilts with two previous vaccinations (inactivated vaccine) and from 9 multiparous sows with three or more vaccinations (inactivated vaccine) that had been exposed to the virus. The IgG antibody titre was determined through anti-PED enzyme-linked immunosorbent assays (ELISA) and the neutralisation of antibodies was evaluated through plaque reduction neutralisation tests (PRNT). The colostrum of nulliparous gilts, when compared to the multiparous sows, presented a lower anti-PED IgG antibody titre as well as fewer neutralising antibodies. Furthermore, the piglets of multiparous sows experienced higher survival in comparison with those of nulliparous gilts (P<0.01), and mortality was dependent on the 'farrowing' variable (P<0.01). In conclusion, these results show that vaccinating nulliparous gilts does not increase the survival of their piglets in comparison with multiparous sows and that the IgG titres and neutralising antibodies are significantly lower in the former. These results suggest that a modified vaccine strategy is needed for nulliparous gilts to increase piglet protection.info:eu-repo/semantics/openAccessUniversidad Austral de Chile. Facultad de Ciencias VeterinariasAustral journal of veterinary sciences v.53 n.3 20212021-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322021000300147en10.4067/S0719-81322021000300147
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	vaccine PED nulliparous colostrum
spellingShingle	vaccine PED nulliparous colostrum Galindo-Castañeda,Lourdes M. Chacón-Salinas,Rommel Quintero,Víctor Sanchez-Betancourt,José I. Cobos-Marín,Laura Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality
description	ABSTRACT Porcine epidemic diarrhoea (PED) is a disease caused by an alphacoronavirus and the symptoms include watery diarrhoea and vomiting, with more than 80% mortality amongst newborn piglets. The placentation in sows hinders the transference of antibodies to the foetus, therefore, the vaccination of pregnant females and transference of antibodies to piglets through colostrum are essential to protect them against virus particles. The aim of the study was to determine whether vaccination of nulliparous gilts could induce a high colostrum antibody titre and lower litter mortality, in comparison with vaccinated multiparous sows previously exposed to the virus. Samples of colostrum were obtained from 11 nulliparous gilts with two previous vaccinations (inactivated vaccine) and from 9 multiparous sows with three or more vaccinations (inactivated vaccine) that had been exposed to the virus. The IgG antibody titre was determined through anti-PED enzyme-linked immunosorbent assays (ELISA) and the neutralisation of antibodies was evaluated through plaque reduction neutralisation tests (PRNT). The colostrum of nulliparous gilts, when compared to the multiparous sows, presented a lower anti-PED IgG antibody titre as well as fewer neutralising antibodies. Furthermore, the piglets of multiparous sows experienced higher survival in comparison with those of nulliparous gilts (P<0.01), and mortality was dependent on the 'farrowing' variable (P<0.01). In conclusion, these results show that vaccinating nulliparous gilts does not increase the survival of their piglets in comparison with multiparous sows and that the IgG titres and neutralising antibodies are significantly lower in the former. These results suggest that a modified vaccine strategy is needed for nulliparous gilts to increase piglet protection.
author	Galindo-Castañeda,Lourdes M. Chacón-Salinas,Rommel Quintero,Víctor Sanchez-Betancourt,José I. Cobos-Marín,Laura
author_facet	Galindo-Castañeda,Lourdes M. Chacón-Salinas,Rommel Quintero,Víctor Sanchez-Betancourt,José I. Cobos-Marín,Laura
author_sort	Galindo-Castañeda,Lourdes M.
title	Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality
title_short	Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality
title_full	Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality
title_fullStr	Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality
title_full_unstemmed	Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality
title_sort	vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality
publisher	Universidad Austral de Chile. Facultad de Ciencias Veterinarias
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-81322021000300147
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Vaccination of nulliparous gilts against porcine epidemic diarrhoea can result in low neutralising antibody titres and high litter mortality

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