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  1. 1621
    To target Tau pathologies, we must embrace and reconstruct their complexities
    por Galina Limorenko, Hilal A. Lashuel
    Publicado 2021
    “... of the defining hallmarks of Tauopathy diseases, including Alzheimer's disease. However, the primary events...”
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  2. 1622
    Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus.
    “... in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD). Due to the overlapping...”
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  3. 1623
    The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells.
    “..., is common to several neurological disorders; these include Alzheimer's disease, Parkinson's disease...”
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  4. 1624
    The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model.
    “... of developing Alzheimer's disease (AD). This is in part because of triplication of a chromosome 21 gene, APP...”
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  5. 1625
    Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration.
    “...'s disease (PD) and Alzheimer's disease (AD) patients has been detected in several studies. This dysbiosis...”
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  6. 1626
    EEG p-adic quantum potential accurately identifies depression, schizophrenia and cognitive decline.
    “... diagnosed with schizophrenia (p<0.0001), depression (p<0.0001), Alzheimer's disease (AD; p<0.0001), and mild...”
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  7. 1627
    PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages
    “..., and more recently PLCG2 to Alzheimer’s disease (AD) pathology. The P522R variant in PLCG2 has been shown...”
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  8. 1628
    High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
    “..., a p.A152T tau variant was identified as a risk factor for FTD, Alzheimer's disease...”
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  9. 1629
    Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice
    “...Abstract Antibodies have been explored extensively as a potential therapeutic for Alzheimer’s...”
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  10. 1630
    Long-term endogenous acetylcholine deficiency potentiates pulmonary inflammation in a murine model of elastase-induced emphysema
    “... such as Alzheimer’s disease patients....”
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  11. 1631
    TOMM40 ‘523’ poly-T repeat length is a determinant of longitudinal cognitive decline in Parkinson’s disease
    “... previously been associated with age of Alzheimer’s disease onset and cognitive functioning in non...”
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  12. 1632
    Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
    “..., and that these compounds should be viewed as potential therapeutics for the treatment of Alzheimer’s disease....”
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  13. 1633
    Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
    por Nicholas P Vyleta, Jason S Snyder
    Publicado 2021
    “... the lateral entorhinal cortex is uniquely vulnerable to aging and Alzheimer's pathology. We therefore...”
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  14. 1634
    The effectiveness of eye tracking in the diagnosis of cognitive disorders: A systematic review and meta-analysis.
    “... impairment (MCI), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), and dementia. Two...”
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  15. 1635
    Acetylcholine esterase inhibitory activity of green synthesized nanosilver by naphthopyrones isolated from marine-derived Aspergillus niger.
    “... invistigated for their inhibitory activity of acetylcholine esterase AChE, a hallmark of Alzheimer's disease...”
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  16. 1636
    Random forest-integrated analysis in AD and LATE brain transcriptome-wide data to identify disease-specific gene expression.
    “...Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects thinking, memory...”
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  17. 1637
    A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia.
    “... of amyotrophic lateral sclerosis (ALS), ~40% of frontotemporal dementia (FTD) and in many cases of Alzheimer...”
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  18. 1638
    Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration
    “...Abstract Caspase-6 (Casp6) is implicated in Alzheimer disease (AD) cognitive impairment...”
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  19. 1639
    Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss
    “... such as Alzheimer’s disease, Parkinson’s disease and traumatic spinal cord injury (SCI). However, to date, no studies...”
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  20. 1640
    Associations of hypertension burden on subsequent dementia: a population-based cohort study
    “... aged ≥ 70 years. Among subjects aged 40–59 years, both vascular and Alzheimer’s dementia risks were...”
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