Technology Advances, High-Risk Research, and a Safe Way Forward

por David R. Franz, James W. Le Duc
Publicado 2021

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using <i>in Silico</i> Approach

por Siaw Shi Boon, Chichao Xia, Maggie Haitian Wang, Ka Lai Yip, Ho Yin Luk, Sile Li, Rita W. Y. Ng, Christopher K. C. Lai, Paul Kay Sheung Chan, Zigui Chen
Publicado 2021

A Prospective, Open-Label Pilot Study of Concurrent Male Partner Treatment for Bacterial Vaginosis

por Erica L. Plummer, Lenka A. Vodstrcil, Michelle Doyle, Jennifer A. Danielewski, Gerald L. Murray, Glenda Fehler, Christopher K. Fairley, Dieter M. Bulach, Suzanne M. Garland, Eric P. F. Chow, Jane S. Hocking, Catriona S. Bradshaw
Publicado 2021

Increased Production of Outer Membrane Vesicles by Salmonella Interferes with Complement-Mediated Innate Immune Attack

por Ruchika Dehinwal, Danielle Cooley, Alexey V. Rakov, Akhil S. Alugupalli, Joey Harmon, Olivier Cunrath, Prashanth Vallabhajosyula, Dirk Bumann, Dieter M. Schifferli
Publicado 2021

Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs

por Lifeng Fu, Shuai Shao, Yong Feng, Fei Ye, Xue Sun, Qingling Wang, Feng Yu, Qisheng Wang, Baoying Huang, Peihua Niu, Xuebing Li, Catherine C. L. Wong, Jianxun Qi, Wenjie Tan, George Fu Gao
Publicado 2021

An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines

por Yan Guo, Wenhui He, Huihui Mou, Lizhou Zhang, Jing Chang, Shoujiao Peng, Amrita Ojha, Rubens Tavora, Mark S. Parcells, Guangxiang Luo, Wenhui Li, Guocai Zhong, Hyeryun Choe, Michael Farzan, Brian D. Quinlan
Publicado 2021

Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus

por Zhonghua Liu, Shriya Raj, Norman van Rhijn, Marcin Fraczek, Jean-Philippe Michel, Odile Sismeiro, Rachel Legendre, Hugo Varet, Thierry Fontaine, Michael Bromley, Jean-Paul Latgé
Publicado 2021

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects

por Lynda Rocheleau, Geneviève Laroche, Kathy Fu, Corina M. Stewart, Abdulhamid O. Mohamud, Marceline Côté, Patrick M. Giguère, Marc-André Langlois, Martin Pelchat
Publicado 2021

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells

por Fernando Villalón-Letelier, Andrew G. Brooks, Sarah L. Londrigan, Patrick C. Reading
Publicado 2021

A Generic, Scalable, and Rapid Time-Resolved Förster Resonance Energy Transfer-Based Assay for Antigen Detection—SARS-CoV-2 as a Proof of Concept

por Juuso Rusanen, Lauri Kareinen, Leonora Szirovicza, Hasan Uğurlu, Lev Levanov, Anu Jääskeläinen, Maarit Ahava, Satu Kurkela, Kalle Saksela, Klaus Hedman, Olli Vapalahti, Jussi Hepojoki
Publicado 2021

Loss of the Bacterial Flagellar Motor Switch Complex upon Cell Lysis

por Mohammed Kaplan, Elitza I. Tocheva, Ariane Briegel, Megan J. Dobro, Yi-Wei Chang, Poorna Subramanian, Alasdair W. McDowall, Morgan Beeby, Grant J. Jensen
Publicado 2021

VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies

por Maria C. Puertas, Ángel Bayón-Gil, Maria C. Garcia-Guerrero, Maria Salgado, Víctor Urrea, Sara Morón-López, Ruth Peña, Esther Jiménez-Moyano, Bonaventura Clotet, Julia G. Prado, Javier Martinez-Picado
Publicado 2021

Human Gut Faecalibacterium prausnitzii Deploys a Highly Efficient Conserved System To Cross-Feed on β-Mannan-Derived Oligosaccharides

por Lars J. Lindstad, Galiana Lo, Shaun Leivers, Zijia Lu, Leszek Michalak, Gabriel V. Pereira, Åsmund K. Røhr, Eric C. Martens, Lauren S. McKee, Petra Louis, Sylvia H. Duncan, Bjørge Westereng, Phillip B. Pope, Sabina Leanti La Rosa
Publicado 2021

Influence of the Alternative Sigma Factor RpoN on Global Gene Expression and Carbon Catabolism in Enterococcus faecalis V583

por Erica C. Keffeler, Vijayalakshmi S. Iyer, Srivatsan Parthasarathy, Matthew M. Ramsey, Matthew J. Gorman, Theresa L. Barke, Sriram Varahan, Sally Olson, Michael S. Gilmore, Zakria H. Abdullahi, Emmaleigh N. Hancock, Lynn E. Hancock
Publicado 2021

Methylation of PhoP by CheR Regulates <i>Salmonella</i> Virulence

por Yang Su, Jianhui Li, Wenting Zhang, Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang, Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, Xiaoyun Liu, Jie Lu, Yu-Feng Yao
Publicado 2021

Lipidation of Class IV CdiA Effector Proteins Promotes Target Cell Recognition during Contact-Dependent Growth Inhibition

por Tiffany M. Halvorsen, Fernando Garza-Sánchez, Zachary C. Ruhe, Nicholas L. Bartelli, Nicole A. Chan, Josephine Y. Nguyen, David A. Low, Christopher S. Hayes
Publicado 2021

DegP Initiates Regulated Processing of Filamentous Hemagglutinin in Bordetella bronchiseptica

por Richard M. Johnson, Zachary M. Nash, Margaret R. Dedloff, John C. Shook, Peggy A. Cotter
Publicado 2021

Global Transcriptional Repression of Diguanylate Cyclases by MucR1 Is Essential for <i>Sinorhizobium</i> -Soybean Symbiosis

por Meng-Lin Li, Jian Jiao, Biliang Zhang, Wen-Tao Shi, Wen-Hao Yu, Chang-Fu Tian
Publicado 2021

Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

por Samuel M. Gonçalves, Daniela Antunes, Luis Leite, Toine Mercier, Rob ter Horst, Joana Vieira, Eduardo Espada, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, António Marques, Frank L. van de Veerdonk, Leo A. B. Joosten, Katrien Lagrou, Johan Maertens, Mihai G. Netea, João F. Lacerda, António Campos, Cristina Cunha, Agostinho Carvalho
Publicado 2021

Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability of the Apical Complex

por Nicolas Dos Santos Pacheco, Nicolò Tosetti, Aarti Krishnan, Romuald Haase, Bohumil Maco, Catherine Suarez, Bingjian Ren, Dominique Soldati-Favre
Publicado 2021