An Open-Source Toolkit To Expand Bioinformatics Training in Infectious Diseases

por Alexander S. F. Berry, Camila Farias Amorim, Corbett L. Berry, Camille M. Syrett, Elise D. English, Daniel P. Beiting
Publicado 2021

Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients

por Jennifer M. Sasson, Joseph J. Campo, Rebecca M. Carpenter, Mary K. Young, Arlo Z. Randall, Krista Trappl-Kimmons, Amit Oberai, Christopher Hung, Joshua Edgar, Andy A. Teng, Jozelyn V. Pablo, Xiaowu Liang, Angela Yee, William A. Petri, David Camerini
Publicado 2021

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles

por Sonu Kumar, Xiaohe Lin, Timothy Ngo, Benjamin Shapero, Cindy Sou, Joel D. Allen, Jeffrey Copps, Lei Zhang, Gabriel Ozorowski, Linling He, Max Crispin, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Publicado 2021

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

por Denise Haslwanter, M. Eugenia Dieterle, Anna Z. Wec, Cecilia M. O’Brien, Mrunal Sakharkar, Catalina Florez, Karen Tong, C. Garrett Rappazzo, Gorka Lasso, Olivia Vergnolle, Ariel S. Wirchnianski, Robert H. Bortz, Ethan Laudermilch, J. Maximilian Fels, Amanda Mengotto, Ryan J. Malonis, George I. Georgiev, Jose A. Quiroz, Daniel Wrapp, Nianshuang Wang, Kathryn E. Dye, Jason Barnhill, John M. Dye, Jason S. McLellan, Johanna P. Daily, Jonathan R. Lai, Andrew S. Herbert, Laura M. Walker, Kartik Chandran, Rohit K. Jangra
Publicado 2021

Linking a Gene Cluster to Atranorin, a Major Cortical Substance of Lichens, through Genetic Dereplication and Heterologous Expression

por Wonyong Kim, Rundong Liu, Sunmin Woo, Kyo Bin Kang, Hyun Park, Young Hyun Yu, Hyung-Ho Ha, Seung-Yoon Oh, Ji Ho Yang, Hangun Kim, Sung-Hwan Yun, Jae-Seoun Hur
Publicado 2021

A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases

por Zhizhen Li, Jianping Wu, Ji Zhou, Baoshi Yuan, Jiqiao Chen, Wanchen Wu, Lian Mo, Zhipeng Qu, Fei Zhou, Yingying Dong, Kai Huang, Zhiwei Liu, Tao Wang, Deebie Symmes, Jingliang Gu, Eiketsu Sho, Jingping Zhang, Ruihuan Chen, Ying Xu
Publicado 2021

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

por Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
Publicado 2021

Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens

por Jaime E. Zlamal, Semen A. Leyn, Mallika Iyer, Marinela L. Elane, Nicholas A. Wong, James W. Wamsley, Maarten Vercruysse, Fernando Garcia-Alcalde, Andrei L. Osterman
Publicado 2021

Nonpneumococcal Strains Recently Recovered from Carriage Specimens and Expressing Capsular Serotypes Highly Related or Identical to Pneumococcal Serotypes 2, 4, 9A, 13, and 23A

por Robert E. Gertz, Fabiana C. Pimenta, Sopio Chochua, Shanda Larson, Anne-Kathryn Venero, Godfrey Bigogo, Jennifer Milucky, Maria da Gloria Carvalho, Bernard Beall
Publicado 2021

The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon

por Xiao-Lian Yang, Gan Wang, Jin-Yan Xie, Han Li, Shu-Xian Chen, Wei Liu, Shu Jeffrey Zhu
Publicado 2021

A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells

por Emma Poole, Maria Cristina Carlan da Silva, Chris Huang, Marianne Perera, Sarah Jackson, Ian J. Groves, Mark Wills, Amer Rana, John Sinclair
Publicado 2021

Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells

por Emily E. Whittle, Helen E. McNeil, Eleftheria Trampari, Mark Webber, Tim W. Overton, Jessica M. A. Blair
Publicado 2021

Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015–2016

por Henju Marjuki, How-Yi Chang, Nadav Topaz, Melissa J. Whaley, Jeni Vuong, Alexander Chen, Laurel T. Jenkins, Fang Hu, Susanna Schmink, Adam C. Retchless, Jennifer D. Thomas, Anna M. Acosta, Lucy A. McNamara, Heidi M. Soeters, Sarah Mbaeyi, Xin Wang
Publicado 2021

SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia

por John Everett, Pascha Hokama, Aoife M. Roche, Shantan Reddy, Young Hwang, Lyanna Kessler, Abigail Glascock, Yize Li, Jillian N. Whelan, Susan R. Weiss, Scott Sherrill-Mix, Kevin McCormick, Samantha A. Whiteside, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Ronald G. Collman, Frederic Bushman
Publicado 2021

Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant <i>Enterobacterales</i> in the United States

por Victor I. Band, Sarah W. Satola, Richard D. Smith, David A. Hufnagel, Chris Bower, Andrew B. Conley, Lavanya Rishishwar, Suzanne E. Dale, Dwight J. Hardy, Roberto L. Vargas, Ghinwa Dumyati, Marion A. Kainer, Erin C. Phipps, Rebecca Pierce, Lucy E. Wilson, Matthew Sorensen, Erik Nilsson, I. King Jordan, Eileen M. Burd, Monica M. Farley, Jesse T. Jacob, Robert K. Ernst, David S. Weiss
Publicado 2021

Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop

por Logan Banadyga, Wenjun Zhu, Shweta Kailasan, Katie A. Howell, Krzysztof Franaszek, Shihua He, Vinayakumar Siragam, Keding Cheng, Feihu Yan, Estella Moffat, Wenguang Cao, Anders Leung, Carissa Embury-Hyatt, M. Javad Aman, Xiangguo Qiu
Publicado 2021

Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antib...

por Shiwen Peng, Louise Ferrall, Stephanie Gaillard, Chenguang Wang, Wei-Yu Chi, Chuan-Hsiang Huang, Richard B. S. Roden, T.-C. Wu, Yung-Nien Chang, Chien-Fu Hung
Publicado 2021

Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets

por Young-Il Kim, Dokyun Kim, Kwang-Min Yu, Hogyu David Seo, Shin-Ae Lee, Mark Anthony B. Casel, Seung-Gyu Jang, Stephanie Kim, WooRam Jung, Chih-Jen Lai, Young Ki Choi, Jae U. Jung
Publicado 2021

Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa

por Tao Li, Yingjie Song, Liming Luo, Ninglin Zhao, Lihui He, Mei Kang, Changcheng Li, Yibo Zhu, Yalin Shen, Chang Zhao, Jing Yang, Qin Huang, Xingyu Mou, Zhiyong Zong, Jinliang Yang, Hong Tang, Yongxing He, Rui Bao
Publicado 2021

Preserve a Voucher Specimen! The Critical Need for Integrating Natural History Collections in Infectious Disease Studies

por Cody W. Thompson, Kendra L. Phelps, Marc W. Allard, Joseph A. Cook, Jonathan L. Dunnum, Adam W. Ferguson, Magnus Gelang, Faisal Ali Anwarali Khan, Deborah L. Paul, DeeAnn M. Reeder, Nancy B. Simmons, Maarten P. M. Vanhove, Paul W. Webala, Marcelo Weksler, C. William Kilpatrick
Publicado 2021