Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic...

por Paola Cappello, Maurizio Martini, Aldo Scarpa, Stefano Ugel, Francesco De Sanctis, Giampaolo Tortora, Emilio Bria, Vincenzo Corbo, Carmine Carbone, Geny Piro, Antonio Agostini, Pietro Delfino, Vincenzo Nasca, Francesco Spallotta, Claudio Sette
Publicado 2021

Heterologous prime-boost vaccination targeting MAGE-type antigens promotes tumor T-cell infiltration and improves checkpoint blockade therapy

por Federica Cappuccini, Emily Pollock, Irina Redchenko, Benoit J Van den Eynde, James McAuliffe, Hok Fung Chan, Laurine Noblecourt, Ramiro Andrei Ramirez-Valdez, Vinnycius Pereira-Almeida, Yaxuan Zhou, Adrian VS Hill, Carol Sze Ki Leung
Publicado 2021

Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic

por Peter F M Choong, Michelle M Dowsey, Samantha Bunzli, Michelle Ghert, Ajay Puri, Robert Turcotte, Penny O'Brien, Peter Rose, Will Aston, Miguel A Ayerza, Lester Chan, Stephane Cherix, Jorge de las Heras, Davide Donati, Uwale Eyesan, Nicola Fabbri, Thomas Hilton, Oluwaseyi Kayode Idowu, Jungo Imanishi, Dundar Sabah, Kristy Weber
Publicado 2021

Surgical aortic valve replacement in the era of transcatheter aortic valve implantation: a review of the UK national database

por Rajamiyer Venkateswaran, Nick Freemantle, Serban Stoica, Marjan Jahangiri, Rajdeep Bilkhu, Max Baghai, Norman Briffa, Martin Jarvis, Keith Buchan, Uday Trivedi, Jon Anderson, Narain Moorjani, Simon Kendall, Paul Ridley, Inderpaul Birdi, Afzal Zaidi, Patrick Yiu, Sunil Ohri, Sunil Bhudia, Prakash Punjabi, Andrew Embleton-Thirsk, Krishna Mani, Vassilios Avlonitis, Karen Booth, Amal Bose, Alex Cale, Indu Deglurkar, Shakil Farid, Leonidas Hadjinikolaou, Seyed Hossein Javadpour, Reubendra Jeganathan, Manoj Kuduvalli, Kulvinder Lall, Jorge Mascaro, Dheeraj Mehta, Christopher Satur
Publicado 2021

Phase II, single-arm trial of preoperative short-course radiotherapy followed by chemotherapy and camrelizumab in locally advanced rectal cancer

por Jun Fan, Tao Zhang, Xin Li, Lan Zhang, Zheng Wang, Tao Liu, Gang Li, Peng Zhang, Chi Ma, Ming Cai, Gang Wu, Zhenyu Lin, Kailin Cai, Xiu Nie, Junli Liu, Hongli Liu, Weikang Zhang, Jingbo Gao, Chuanqing Wu, Linfang Wang, Zhiguo Hou, Kunyu Yang, Kaixiong Tao
Publicado 2021

Humoral immunogenicity of the seasonal influenza vaccine before and after CAR-T-cell therapy: a prospective observational study

por Helen Y Chu, Caitlin R Wolf, Rebecca A Gardner, Cameron J Turtle, Joshua A Hill, Carla S Walti, Andrea N Loes, Kiel Shuey, Elizabeth M Krantz, Jim Boonyaratanakornkit, Jacob Keane-Candib, Tillie Loeffelholz, Justin J Taylor, Damian J Green, Andrew J Cowan, David G Maloney, Steven A Pergam, Jesse D Bloom
Publicado 2021

Pembrolizumab with low-dose carboplatin for recurrent platinum-resistant ovarian, fallopian tube, and primary peritoneal cancer: survival and immune correlates

por Mary L Disis, John B Liao, Doreen M Higgins, Jennifer S Childs, Sasha E Stanton, Anna V Tinker, William R Gwin, Renata R Urban, Katie M Hitchcock-Bernhardt, Andrew L Coveler, Hania N Shakalia, Ron E Swensen, Tanya A Wahl, Richard G Ancheta, Kathryn F McGonigle, James Y Dai, Barbara A Goff
Publicado 2021

Patient and caregiver factors in ambulatory incident reports: a mixed-methods analysis

por Urmimala Sarkar, Judith Burns, W John Boscardin, Anjana E Sharma, Beatrice Huang, Jan Bing Del Rosario, Janine Yang, Ana Vilma Aquino, Robin Cotterhill, Barbara Glassey, Roxie Harris, Sharon Kincaid, Shin-Yu Lee, Lydia Leung, C Damaris Mendez, Patrick McKenna, Isela Mosteiro, Kathleen Noonan, Adeola Oni- Orisan, Jane Redmond, Forrest Thompson
Publicado 2021

Clinical characteristics of non-radiographic versus radiographic axial spondyloarthritis in Asia and non-radiographic axial spondyloarthritis in other regions: results of the cross...

por Désirée van der Heijde, Yuko Kaneko, Clementina López-Medina, Atsuo Taniguchi, Masato Okada, Shigeto Kobayashi, Tetsuya Tomita, Kazuki Yoshida, Yoshinori Komagata, Keisuke Ono, Gautam A Deshpande, Shinya Kaname, Shigeyoshi Tsuji, Yoshinori Taniguchi, Naomi Ichikawa, Taku Kawasaki, Kazuo Matsui, Kurisu Tada, Naoho Takizawa, Naoto Tamura, Sho Fukui, Satoshi Kawaai, Mitsuhro Morita
Publicado 2021

Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension

por Karine Briot, Rachel K Crowley, Maria Luisa Brandi, Stuart H Ralston, Han-Wook Yoo, Peter Kamenický, Takuo Kubota, Nobuaki Ito, Martine Cohen-Solal, Richard Keen, Angela Williams, Muhammad K Javaid, Hiroyuki Tanaka, Robin H Lachmann, Karl Insogna, Richard Eastell, Yasuhiro Takeuchi, Anthony A Portale, Thomas O Carpenter, Hae Ii Cheong, Yasuo Imanishi, Steven Ing, Suzanne Jan de Beur, Farzana Perwad, Pisit Pitukcheewanont, Thomas J Weber, Annabel Nixon, Mark Nixon, Erik A Imel
Publicado 2021

COVID outcome prediction in the emergency department (COPE): using retrospective Dutch hospital data to develop simple and valid models for predicting mortality and need for intens...

por Annelies Verbon, David M Kent, David van Klaveren, Rozemarijn L van Bruchem-Visser, Stephanie C E Schuit, Alexandros Rekkas, Rob J C G Verdonschot, Dick T J J Koning, Marlijn J A Kamps, Robert Stassen, Sebastiaan Weijer, Klaas-Sierk Arnold, Benjamin Tomlow, Hilde R H de Geus, Jelle R Miedema, Els van Nood
Publicado 2021

Immune checkpoint inhibitors in patients with pre-existing psoriasis: safety and efficacy

por Andrew Haydon, Jessica C Hassel, Jeffrey A Sosman, Sunandana Chandra, Ryan Sullivan, Mario E Lacouture, Meghan J Mooradian, Alexander Menzies, Douglas B Johnson, Fei Ye, Prachi Bhave, Steven T Chen, Georgina Long, Briana Rose Halle, Farzana Y Zaman, Anna K Dewan, Rebecca Irlmeier, Paras Mehta, Nicholas R Kurtansky, Jacob S Choi, Tracey S Otto, Florentia Dimitriou, Veronica M Rotemberg
Publicado 2021

Varying association of laboratory values with reference ranges and outcomes in critically ill patients: an analysis of data from five databases in four countries across Asia, Europ...

por Xiaoli Liu, Leo Anthony Celi, Haoran Xu, Louis Agha-Mir-Salim, Zachary O’Brien, Dora C Huang, Peiyao Li, Josep Gómez, Tongbo Liu, Patrick Thoral, Paul Elbers, Zhengbo Zhang, María Bodí Saera
Publicado 2021

Screening for SARS-CoV-2 infection in asymptomatic individuals using the Panbio COVID-19 antigen rapid test (Abbott) compared with RT-PCR: a prospective cohort study

por Edwin Goedhart, Patrick Krastman, Afke H Brandenburg, Hendrik Gremmels, Beatrice Winkel, Emma Schram, Sylvia Debast, Rob Schuurman, Annemarie Wensing, Marije Hofstra, Tim Baijens, Marjan J Bruins, Bas Bulder, Wouter ten Cate, Juliete Djapo Tiani, Joost van der Hoek, Jannes Hornstra, Simon Knops, Maurine Leversteijn van Hall, Prabath Lodewijks, Frank Nab, Ron Peters, Mineke Vegter, Wart van Zoest
Publicado 2021

Study protocol: the ear–nose–throat (ENT) prospective international cohort of patients with primary ciliary dyskinesia (EPIC-PCD)

por Andreas Anagiotos, Myrofora Goutaki, André Coste, Nagehan Emiralioglu, Amanda Harris, Andrea Burgess, Mieke Boon, Philipp Latzin, Jean François Papon, Eric G Haarman, Natalie Lorent, Yin Ting Lam, Mihaela Alexandru, Miguel Armengot, Emilie Bequignon, Ela Erdem, Sara-Lynn Hool, Bulent Karadag, Sookyung Kim, Ugur Ozcelik, Ana Reula, Jobst Roehmel, Christine van Gogh, Panayiotis Yiallouros, Soeren Marian Zappe
Publicado 2021

Prospective randomised trial examining the impact of an educational intervention versus usual care on anticoagulation therapy control based on an SAMe-TT2R2 score-guided strategy i...

por Kate Jolly, Gregory Y H Lip, Anita Slade, Jonathan Mathers, Sue Jowett, Gemma Slinn, Arintaya Phrommintikul, G Neil Thomas, Samir Mehta, Antika Wongthanee, Rungroj Krittayaphong, Deirdre Lane, Surakit Nathisuwan, Siriluck Gunaparn, Sukhi Sehmi, Neil Winkles, Narawudt Prasertwitayakij, Wattana Wongtheptien, Thanyaluck Chotayaporn, Natrawee Bureekam, Bancha Sookananchai, Vichai Senthong
Publicado 2021

Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response

por Saly Al-Taei, Sian E Faustini, Marisol Perez-Toledo, Sian Jossi, Joel D Allen, Claire Backhouse, Daniel Ebanks, Beena Emmanuel, Mark Garvey, Golaleh McGinnell, Yasunori Watanabe, Max Crispin, David C Wraith, Adam F Cunningham, Mark T Drayson, Alex G Richter, Adrian M Shields, Lynsey A Dunbar, Aduragbemi A Faniyi, Annabel Grinbergs, Joanne O'Neill
Publicado 2021

Assessing the development status of intraoperative fluorescence imaging for perfusion assessments, using the IDEAL framework

por Charles Sabbagh, Peter McCulloch, Mikiya Takao, Norihiro Kokudo, Steven D Wexner, Frederic Ris, Antonino Spinelli, Kevin White, Rutger M Schols, Ronan Cahill, Luigi Boni, Michael Bouvet, Kiyoshi Hasegawa, Takeaki Ishizawa, Derek Muehrcke, Thomas Carus, Ory Wiesel, Giovanni Dapri, Sylke Schneider-Koriath, Mahmoud Abu-Gazala, Elisa Cassinotti, Michele Carvello, Eric Vibert, Muga Terasawa, Tim Pruimboom, Yasuo Murai, Fumihiro Matano, Michele Diana, Fernando Dip, Raul J Rosenthal
Publicado 2021

Engaging local health research communities to enhance long-term capacity building in Brazil

por Nina E Jamieson, Trudie Lang, Bruno Gomes, Egmar Longo, Luiza Helena Madia Lourenço, Bonny Louise Baker, Antonio Gregorio Dias Junior, Roque Pacheco de Almeida, Ricardo Queiroz Gurgel, Cristiane Campello Bresani Salvi, Clécio Gabriel de Souza, Mariana Rocha David, Márcio Galvão Pavan, Daniele Pereira de Castro, Mauricio Lacerda Nogueira
Publicado 2021