Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability i...

por Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani, Massimo Mantegazza
Publicado 2021

Machine learning reveals mesenchymal breast carcinoma cell adaptation in response to matrix stiffness.

por Vlada S Rozova, Ayad G Anwer, Anna E Guller, Hamidreza Aboulkheyr Es, Zahra Khabir, Anastasiya I Sokolova, Maxim U Gavrilov, Ewa M Goldys, Majid Ebrahimi Warkiani, Jean Paul Thiery, Andrei V Zvyagin
Publicado 2021

The transcription factor LAG-1/CSL plays a Notch-independent role in controlling terminal differentiation, fate maintenance, and plasticity of serotonergic chemosensory neurons.

por Miren Maicas, Ángela Jimeno-Martín, Andrea Millán-Trejo, Mark J Alkema, Nuria Flames
Publicado 2021

Cell-level metadata are indispensable for documenting single-cell sequencing datasets.

por Sidhant Puntambekar, Jay R Hesselberth, Kent A Riemondy, Rui Fu
Publicado 2021

An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation.

por Nathan E Cross, Florence B Pomares, Alex Nguyen, Aurore A Perrault, Aude Jegou, Makoto Uji, Kangjoo Lee, Fatemeh Razavipour, Obaï Bin Ka'b Ali, Umit Aydin, Habib Benali, Christophe Grova, Thien Thanh Dang-Vu
Publicado 2021

Understanding degraded speech leads to perceptual gating of a brainstem reflex in human listeners.

por Heivet Hernández-Pérez, Jason Mikiel-Hunter, David McAlpine, Sumitrajit Dhar, Sriram Boothalingam, Jessica J M Monaghan, Catherine M McMahon
Publicado 2021

Twenty steps to ingrain power asymmetry in global health biomedical research.

por Iruka N Okeke
Publicado 2021

Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function.

por Nina L Kikel-Coury, Jacob P Brandt, Isabel A Correia, Michael R O'Dea, Dana F DeSantis, Felicity Sterling, Kevin Vaughan, Gulberk Ozcebe, Pinar Zorlutuna, Cody J Smith
Publicado 2021

Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants.

por Qiu-Wen Wang, Ying-Han Wang, Bing Wang, Yun Chen, Si-Yao Lu, Jun Yao
Publicado 2021

Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.

por Suzanne van der Veldt, Guillaume Etter, Coralie-Anne Mosser, Frédéric Manseau, Sylvain Williams
Publicado 2021

A survey of biomedical journals to detect editorial bias and nepotistic behavior.

por Alexandre Scanff, Florian Naudet, Ioana A Cristea, David Moher, Dorothy V M Bishop, Clara Locher
Publicado 2021

Educating the future generation of researchers: A cross-disciplinary survey of trends in analysis methods.

por Taylor Bolt, Jason S Nomi, Danilo Bzdok, Lucina Q Uddin
Publicado 2021

BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury.

por Lianyan Huang, Jianhua Jin, Kai Chen, Sikun You, Hongyang Zhang, Alexandra Sideris, Monica Norcini, Esperanza Recio-Pinto, Jing Wang, Wen-Biao Gan, Guang Yang
Publicado 2021

MycoRed: Betalain pigments enable in vivo real-time visualisation of arbuscular mycorrhizal colonisation.

por Alfonso Timoneda, Temur Yunusov, Clement Quan, Aleksandr Gavrin, Samuel F Brockington, Sebastian Schornack
Publicado 2021

Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype.

por Virginie Lam, Ryusuke Takechi, Mark J Hackett, Roslyn Francis, Michael Bynevelt, Liesl M Celliers, Michael Nesbit, Somayra Mamsa, Frank Arfuso, Sukanya Das, Frank Koentgen, Maree Hagan, Lincoln Codd, Kirsty Richardson, Brenton O'Mara, Rainer K Scharli, Laurence Morandeau, Jonathan Gauntlett, Christopher Leatherday, Jan Boucek, John C L Mamo
Publicado 2021

PhyloFisher: A phylogenomic package for resolving eukaryotic relationships.

por Alexander K Tice, David Žihala, Tomáš Pánek, Robert E Jones, Eric D Salomaki, Serafim Nenarokov, Fabien Burki, Marek Eliáš, Laura Eme, Andrew J Roger, Antonis Rokas, Xing-Xing Shen, Jürgen F H Strassert, Martin Kolísko, Matthew W Brown
Publicado 2021

Natural experiments and long-term monitoring are critical to understand and predict marine host-microbe ecology and evolution.

por Matthieu Leray, Laetitia G E Wilkins, Amy Apprill, Holly M Bik, Friederike Clever, Sean R Connolly, Marina E De León, J Emmett Duffy, Leïla Ezzat, Sarah Gignoux-Wolfsohn, Edward Allen Herre, Jonathan Z Kaye, David I Kline, Jordan G Kueneman, Melissa K McCormick, W Owen McMillan, Aaron O'Dea, Tiago J Pereira, Jillian M Petersen, Daniel F Petticord, Mark E Torchin, Rebecca Vega Thurber, Elin Videvall, William T Wcislo, Benedict Yuen, Jonathan A Eisen
Publicado 2021

The economics of managing evolution.

por Troy Day, David A Kennedy, Andrew F Read, David McAdams
Publicado 2021

Relaxed phylogenetics and dating with confidence.

por Alexei J Drummond, Simon Y W Ho, Matthew J Phillips, Andrew Rambaut
Publicado 2006

Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues.

por Barbara Arbeithuber, James Hester, Marzia A Cremona, Nicholas Stoler, Arslan Zaidi, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J Diaz, Kateryna D Makova
Publicado 2020