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  1. 22801
    IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
    “...The alternative mechanisms of innate immunity in tumorigenesis of colorectal cancers are unclear...”
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  2. 22802
    Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
    “...6-phosphogluconate dehydrogenase is commonly upregulated in cancers. Here, the authors show...”
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  3. 22803
    Investigation of abnormal histology and cytology of cervix
    por N Asnafi, SH Shafaei, SH Abdol Maleki
    Publicado 2004
    “... with cancerous and invasive lesions. Prevalence of cancerous lesion was 0.22%. Abnormal histologic results were...”
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  4. 22804
    Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting
    “... occurs in other ErbB receptors in multiple cancers, and characterize the mechanism and inhibition of EGFR...”
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  5. 22805
    SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
    “...SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4...”
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  6. 22806
    Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
    “...Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great...”
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  7. 22807
    A synergetic effect of BARD1 mutations on tumorigenesis
    “...Mutations in the BARD1 gene have been identified as risk factors in breast and ovarian cancers...”
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  8. 22808
    Gene isoforms as expression-based biomarkers predictive of drug response in vitro
    “...Altered mRNA splicing features in many cancers, but it has not been linked to drug response. Here...”
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  9. 22809
    LNK suppresses interferon signaling in melanoma
    “...LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here...”
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  10. 22810
    Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
    “... that can leverage multiple samples to improve somatic variant calling in different cancers....”
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  11. 22811
    An unusual case in endocrinology practice: Suture granuloma
    “... of thyroid cancers....”
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  12. 22812
    The Cyclin Cln1 Controls Polyploid Titan Cell Formation following a Stress-Induced G <sub>2</sub> Arrest in Cryptococcus
    “... Dysregulation of the cell cycle underlies many human genetic diseases and cancers, yet numerous...”
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  13. 22813
    Enhancing myocardial repair with CardioClusters
    “... rivals most cancers. Here, the authors describe an approach to control and pattern 3 distinct human...”
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  14. 22814
    Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
    “...Levels of the transcription factor Myc are deregulated in a range of different cancers. Here...”
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  15. 22815
    Non-canonical NOTCH3 signalling limits tumour angiogenesis
    “...Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway...”
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  16. 22816
    Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
    “...Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key...”
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  17. 22817
    The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
    “...The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors...”
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  18. 22818
    A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
    “...Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8...”
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  19. 22819
    Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
    “... on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator...”
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  20. 22820
    Spatial constraints govern competition of mutant clones in human epidermis
    “...Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here...”
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