Mostrando 761 - 780 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.09s Limitar resultados
  1. 761
    RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
    “... residues. Here, the authors use a CRISPR whole genome screen to identify that protein phosphatase 1...”
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  2. 762
    Engineering monocyte/macrophage−specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing
    “... expression. Here, the authors describe a CRISPR/Cas9-based gene-editing approach to re-express this enzyme...”
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  3. 763
    GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
    “... is unclear. Here, the authors utilise CRISPR-Cas9 to model frame-shift mutations in zinc finger 2 of GATA3...”
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  4. 764
    Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
    “...CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced...”
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  5. 765
    Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease
    “...CRISPR-Cas9 systems are being continually improved to enhance specificity and improve functionality...”
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  6. 766
    Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
    “... it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic...”
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  7. 767
    DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
    “... and for CRISPR/Cas9-based systems. Here the authors show that DNA-bound Tet-transactivators can induce cell death...”
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  8. 768
    Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
    “.... Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use...”
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  9. 769
    Characterizing a thermostable Cas9 for bacterial genome editing and silencing
    “...CRISPR-Cas9 genome engineering tools have found wide application in a range of species, however...”
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  10. 770
    Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
    “..., the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect...”
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  11. 771
    A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
    “..., the authors investigate a kidney disease GWAS locus with functional genomics data, CRISPR editing and mouse...”
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  12. 772
    Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo
    “...Optimization of the recently discovered Class 2 CRISPR protein Cpf1 has the potential to promote...”
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  13. 773
    Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
    “...Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene...”
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  14. 774
    Structural basis for assembly of non-canonical small subunits into type I-C Cascade
    “...Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system...”
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  15. 775
    The molecular basis for recognition of 5′-NNNCC-3′ PAM and its methylation state by Acidothermus cellulolyticus Cas9
    “...Acidothermus cellulolyticus CRISPR-Cas9 (AceCas9) is a Type II-C enzyme that cleaves DNA in a...”
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  16. 776
    Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
    “..., can alter transcription factor binding, and use CRISPR-Cas9 to reveal localization...”
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  17. 777
    Multiplex secretome engineering enhances recombinant protein production and purity
    “... the authors use modelling and CRISPR to delete secreted host proteins in CHO cells, leading to improved...”
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  18. 778
    Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice
    “..., based on combined CRISPR-Cas9 and micro-homology-mediated end joining....”
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  19. 779
    Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements
    “... and development of Plasmodium falciparum and use CRISPR-mediated gene knockout and complementation of an invasion...”
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  20. 780
    Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization
    “...CRISPR/Cas9-based genome editing enables specific deletion of target genes. Here, Senturket al...”
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