Mostrando 801 - 820 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.13s Limitar resultados
  1. 801
    Characteristics of Wetting-Induced Bacteriophage Blooms in Biological Soil Crust
    “... in biocrusts. Prophage elements and CRISPR-Cas repeats in Firmicutes metagenome-assembled genomes (MAGs...”
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  2. 802
    Highly Variable <named-content content-type="genus-species">Streptococcus oralis</named-content> Strains Are Common among Viridans Streptococci Isolated from Primates
    “... interspaced short palindromic repeat (CRISPR)–CRISPR-associated protein (Cas) gene clusters were common among...”
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  3. 803
    FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat
    “... that FKBP3 may be related to HIV-1 latency using CRISPR screening. In this study, we knocked out the FKBP3...”
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  4. 804
    STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
    “... roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role...”
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  5. 805
    SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling
    “... develop a CRISPR-Cas9 screen targeting epigenetic regulators and discover that SIRT6 haploinsufficiency...”
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  6. 806
    The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
    “..., by characterizing a null mutant created by CRISPR, the authors show that previous reported function of H2A.W...”
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  7. 807
    Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
    “...CRISPR-Cas9 screens are powerful high-throughput tools but can be confounded by nuclease toxicity...”
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  8. 808
    Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
    “.... Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing...”
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  9. 809
    Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome
    “... blood disorders. Here the authors develop a CRISPR/Cas9-based genome editing strategy that allows...”
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  10. 810
    Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
    “... and demonstrate potential correction of the phenotype by CRISPR based editing....”
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  11. 811
    Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
    “.... Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve...”
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  12. 812
    Marine biofilms constitute a bank of hidden microbial diversity and functional potential
    “... diversity in the oceans by more than 20% and revealing new biosynthetic gene clusters and CRISPR-Cas systems....”
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  13. 813
    Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
    “... of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3...”
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  14. 814
    Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity
    “..., the authors present a CRISPR/Cas9-based platform to simultaneously investigate multiple activating point...”
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  15. 815
    Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing
    “...Resistance of gRNA to ubiquitous ribonucleases is required for CRISPR-Cas9-based therapeutics. Here...”
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  16. 816
    Allele-aware chromosome-level genome assembly and efficient transgene-free genome editing for the autotetraploid cultivated alfalfa
    “... assembly of the autotetraploid genome and a CRISPR/Cas9-based transgene-free genome editing protocol....”
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  17. 817
    Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency
    “... reactivation. Clustered regularly interspaced short palindromic repeat(s) (CRISPR)-mediated knockout of EZH2...”
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  18. 818
    MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca<sup>2+</sup> Uptake, Growth, and Infectivity of the Human Pathogen <named-content content-type="genus-species">Trypanosoma cruzi</named-content>
    “... the CRISPR/Cas9 system (i.e., clustered regularly interspaced short palindromic repeats with Cas9), we...”
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  19. 819
    Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection
    “... regularly interspaced short palindromic repeat (CRISPR)/Cas9-mediated knockouts in primary fibroblasts...”
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  20. 820
    Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
    “... yielded 54 novel regulators of PrPC, 9 of which were confirmed by CRISPR interference as robust regulators...”
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