Mostrando 921 - 940 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.21s Limitar resultados
  1. 921
    A simple and economic protocol for efficient in vitro fertilization using cryopreserved mouse sperm
    “...The advent of genome editing tools like CRISPR/Cas has substantially increased the number...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  2. 922
    Heading towards a dead end: The role of DND1 in germ line differentiation of human iPSCs.
    “... pluripotency and human germline development. Here we use CRISPR/Cas mediated knockout and PGC-like cell (PGCLC...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  3. 923
    The Nestin neural enhancer is essential for normal levels of endogenous Nestin in neuroprogenitors but is not required for embryo development.
    “... in cultured cells and in vivo. We generated CRISPR deletions of the enhancer region in mice and assessed...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  4. 924
    A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter.
    “...) mouse line was generated via CRISPR/Cas9 technology. The TAG stop codon was replaced by a 2A-NLS-Cre...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  5. 925
    Genetic disruption of Plasmodium falciparum Merozoite surface antigen 180 (PfMSA180) suggests an essential role during parasite egress from erythrocytes
    “... pfmsa180-gene knockout generated using CRISPR/Cas9 and DiCre recombinase technology, we demonstrate...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  6. 926
    Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS
    “... and immunology techniques, by employing IRG1-null (prepared with CRISPR) and wild-type macrophages. Experimental...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  7. 927
    Genomic and experimental data provide new insights into luciferin biosynthesis and bioluminescence evolution in fireflies
    “... of luminous organs of two species. We created the CRISPR/Cas9-induced mutants of Abdominal B gene without...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  8. 928
    Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies
    “... CRISPR/Cas9, while MICA and MICB genes were removed in this study. A panel of 11 cell lines expressing...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  9. 929
    A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells
    “..., resulting from CRISPR-Cas9 deletion of the PIR, increased the expression of MSX1. We conclude that STX18-AS1...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  10. 930
    Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells.
    “... is known about the transcriptional regulation of Ripk3. Here we utilized an unbiased CRISPR-based...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  11. 931
    The Drosophila Baramicin polypeptide gene protects against fungal infection.
    “... of these short effector genes until the recent advent of the CRISPR/CAS era. As a consequence, many putative...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  12. 932
    Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans.
    “... the cardiovascular similarities between pigs and humans, we generated ASGR1-deficient pigs using the CRISPR/Cas9...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  13. 933
    Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness.
    “.... To better understand the mechanism and cellular impact of helicase regulation, we used CRISPR-Cas9 genome...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  14. 934
    Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans.
    “... phenotypes of NFU1 variants, we used CRISPR/Cas9 gene editing to recreate exact patient variants of NFU1...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  15. 935
    Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses
    “... sequentially disrupted in immortalized porcine endothelial cells using CRISPR/Cas9 technology. The elimination...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  16. 936
    NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations
    “... NBS1 I171V variant homozygous knock-in HCT116 cells and mice using the CRISPR/Cas9 system. Radiation...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  17. 937
    ZBED6 regulates Igf2 expression partially through its regulation of miR483 expression
    “... of miR483 expression when the ZBED6-Igf2 axis is disrupted in transgenic mice. Furthermore, CRISPR/Cas9...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  18. 938
    Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome
    “... CRISPR edited line and its isogeneic control, demonstrated that R47H-expressing iPS-Mg expressed a...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  19. 939
    Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth
    “..., we used CRISPR/Cas9 to knockout SNCA, the gene that codes for α-syn, in SK-Mel-28 melanoma cells...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  20. 940
    Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)
    “... and TAL1 by mass spectrometry and ChIP-seq. Haploinsufficient but not complete CRISPR knock-out of USP7...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
Herramientas de búsqueda: RSS — Enviar por Correo electrónico esta Búsqueda — Guardar Búsqueda