Mostrando 941 - 960 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.06s Limitar resultados
  1. 941
    Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation
    “... limitations in the biomedical device field. We have developed RAG2/IL2RG deficient pigs using CRISPR/Cas9 as a...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  2. 942
    Single molecule network analysis identifies structural changes to caveolae and scaffolds due to mutation of the caveolin-1 scaffolding domain
    “... of the CAV1 CSD F92A/V94A mutant in CRISPR/Cas CAV1 knockout MDA-MB-231 breast cancer cells reduces the size...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  3. 943
    SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells
    “..., including intellectual disability and autism spectrum disorders (ASD). Using CRISPR/Cas9 genome editing, we...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  4. 944
    Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
    “.... The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  5. 945
    A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells
    “...-type H727 cells. Following lentiviral CRISPR/Cas9-mediated miR-375 depletion, we identified distinct...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  6. 946
    Rapid target validation in a Cas9-inducible hiPSC derived kidney model
    “... methodology for direct differentiation of the CRISPR-targeted cell pools, using a doxycycline-inducible Cas9...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  7. 947
    A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse
    “... consuming breeding. This is considerably significant when one is dealing with multiple genes. CRISPR/Cas9...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  8. 948
    Natural and induced loss of function mutations in SlMBP21 MADS-box gene led to jointless-2 phenotype in tomato
    “... with j-2 phenotype. Targeted knockout of Solyc12g038510, using CRISPR/Cas9 system, validated our...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  9. 949
    Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats
    “... a deletion in the Prkar1b gene of the WTC-furue genome. Prkar1b-deficient rats created by the CRISPR...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  10. 950
    PLEKHG5 regulates autophagy, survival and MGMT expression in U251-MG glioblastoma cells
    “... for understanding PLEKHG5 signalling is the study purpose. We generated a CRISPR/Cas9-mediated knockout of PLEKHG5...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  11. 951
    <i>In Silico</i> Structural and Functional Annotation of Nine Essential Hypothetical Proteins from <i>Streptococcus pneumoniae</i>
    “... machinery. A previous CRISPR interference (CRISPRi) study had identified 254 essential proteins that may...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  12. 952
    HLA-G gene editing in tumor cell lines as a novel alternative in cancer immunotherapy
    “... a tolerogenic microenvironment. Here, we used CRISPR/Cas9 gene editing to block the HLA-G expression...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  13. 953
    A separation-of-function ZIP4 wheat mutant allows crossover between related chromosomes and is meiotically stable
    “... described CRISPR Tazip4-B2 and ph1 mutant lines. The results also reveal that loss of suppression...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  14. 954
    Salinity tolerance mechanisms and their breeding implications
    “..., hyperspectral imaging, and CRISPR/Cas serve as engineering tools for dissecting the in-depth physiological...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  15. 955
    Mutants of the Zebrafish K<sup>+</sup> Channel Hcn2b Exhibit Epileptic-like Behaviors
    “... a wide variety of diseases. In this work, we used CRISPR/Cas9 to generate <i>hcn2b</i> mutants...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  16. 956
    PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction
    “... zebrafish line by using the CRISPR/Cas9 system targeting <i>rnf2</i>, a gene encoding the core subunit...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  17. 957
    Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies <i>TOP2A</i> as a Therapeutic Target for Rectal Cancer
    “... or expression levels with the sensitivity to topoisomerase II inhibitors. Furthermore, CRISPR-Cas9 and shRNA...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  18. 958
    Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis
    “...-apoptotic effector T cell mechanisms. Indeed, CRISPR/Cas9-mediated CD47-knockout rendered cancer cells more...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  19. 959
    Trihelix Transcription Factor <i>ZmThx20</i> Is Required for Kernel Development in Maize
    “... factor, <i>ZmThx20</i>. Using CRISPR/Cas9, two other alleles with mutated <i>ZmThx20</i> were found...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
  20. 960
    Heat-Moisture Treatment Further Reduces In Vitro Digestibility and Enhances Resistant Starch Content of a High-Resistant Starch and Low-Glutelin Rice
    “...) but low in glutelin has been developed through CRISPR/Cas9-mediated targeted mutagenesis for its potential...”
    Enlace del recurso
    article
    Agregar a favoritos
    Guardado en:
Herramientas de búsqueda: RSS — Enviar por Correo electrónico esta Búsqueda — Guardar Búsqueda