Mostrando 1,001 - 1,020 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.23s Limitar resultados
  1. 1001
    Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference.
    “... yielded 54 novel regulators of PrPC, 9 of which were confirmed by CRISPR interference as robust regulators...”
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  2. 1002
    Specific interaction of an RNA-binding protein with the 3'-UTR of its target mRNA is critical to oomycete sexual reproduction.
    “.... We developed the first CRISPR/Cas9 system-mediated gene knockout and in situ complementation methods...”
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  3. 1003
    Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants.
    “... variants, suggests the use of an alternative receptor(s). In this study, we used a genome-wide CRISPR Cas9...”
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  4. 1004
    Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila.
    “... point mutations at the corresponding residue His698 in Drosophila using the CRISPR-Cas9 technique. Two...”
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  5. 1005
    Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development.
    “... ancestors beyond the Drosophila genus. The transcriptional compensation effect from CRISPR knockout were...”
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  6. 1006
    The SUMO ligase MMS21 profoundly influences maize development through its impact on genome activity and stability.
    “... of UniformMu and CRISPR/Cas9 mutants in maize (Zea mays) that display either seed lethality or substantially...”
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  7. 1007
    Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V
    “... prevalence of diabetes. We developed a mouse model with a LoF Kcnq1 mutation using CRISPR-Cas9...”
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  8. 1008
    DNMT3.1 controls trade-offs between growth, reproduction, and life span under starved conditions in Daphnia magna
    “... for controlling energy allocation between life history traits still remain unknown. Here, we report CRISPR/Cas...”
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  9. 1009
    Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects
    “... essential for renal Mg2+ reabsorption. Here, we used a Cnnm2 knock out mouse model, generated by CRISPR/Cas9...”
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  10. 1010
    Zbp1-positive cells are osteogenic progenitors in periodontal ligament
    “.... The CRISPR/Cas9 mediated Zbp1 knockout in the high clones resulted in a delay in cell differentiation...”
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  11. 1011
    Utilizing a chromosomal-length genome assembly to annotate the Wnt signaling pathway in the Asian citrus psyllid, Diaphorina citri
    “... gene models. These gene models can be used to develop molecular systems, such as CRISPR and RNAi, which...”
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  12. 1012
    SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms
    “... function and immune-mediated tumor regression. Knockout of SHP2 using CRISPR/Cas9 gene editing showed...”
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  13. 1013
    Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure
    “... of proline from glutamate. Interestingly, depletion of P5CS by CRISPR/Cas9 resulted in a significant increase...”
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  14. 1014
    MiR-125b-2 knockout increases high-fat diet-induced fat accumulation and insulin resistance
    “... unknown. In the present study, miR-125b-2 knockout mice were generated using CRISPR/CAS9 technology...”
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  15. 1015
    A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition
    “... single cell reporter for Cdk2 activation, RB inactivation and cell cycle entry by CRISPR/Cas9 tagging...”
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  16. 1016
    Gα15 in early onset of pancreatic ductal adenocarcinoma
    “... or CRISPR/Cas9 affected oncogenic signaling, and reduced adenocarcimoma cell motility and invasiveness. We...”
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  17. 1017
    HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4
    “... in both models. We next knocked out HtrA4 in BeWo by CRISPR/Cas9. Upon forskolin treatment, control BeWo...”
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  18. 1018
    miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models
    “... achieved using CRISPR/Cas9 gene editing technology. Compared with H. pylori-infected wild-type mice, H...”
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  19. 1019
    Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts
    “... CRISPR-associated proteins and restriction-modification systems. Together, our results provide...”
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  20. 1020
    MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome
    “... with isogenic controls, using CRISPR/Cas9 technology, and differentiated them towards neural crest cells...”
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