Mostrando 41 - 60 Resultados de 189 Para Buscar '"Gene targeting"', tiempo de consulta: 0.15s Limitar resultados
  1. 41
    DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.
    “... demonstrate that Artemis-null human cells display increased gene-targeting efficiencies, particularly...”
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  2. 42
    Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis
    “...Abstract Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation...”
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  3. 43
    A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse
    “... deletion. Compared to conventional gene knockout (KO), conditional knockout (cKO) provides an advanced gene...”
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  4. 44
    The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice.
    “... to address its physiological function, we have generated mice lacking Maestro using gene targeting. Male...”
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  5. 45
    Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.
    “... model by gene targeting. The Sepn1(-/-) mice had normal growth and lifespan, and were macroscopically...”
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  6. 46
    Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities—an analysis of CRISPR genome-edited mouse embryos
    “... protein (Cas) system is a rapid gene-targeting technology that does not require embryonic stem cells...”
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  7. 47
    Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach.
    “... via re-iterative gene targeting. A total of 13 open reading frames contained in 25 kb of DNA were...”
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  8. 48
    Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts
    “... remained elusive. Gene targeting in mice implicated CAP2 in heart physiology and skeletal muscle...”
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  9. 49
    OncomiR miR-182-5p Enhances Radiosensitivity by Inhibiting the Radiation-Induced Antioxidant Effect through SESN2 in Head and Neck Cancer
    “.... By intersecting the gene targeting results from three microRNA target prediction databases, we noticed...”
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  10. 50
    Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases.
    “... DNA gene-targeting vector to achieve the first gene knockout and targeted sequence replacement...”
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  11. 51
    Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity.
    “... of the Leishmania infantum mitochondrial TXN (LiTXN2) by gene-targeting, had no significant effect on parasite...”
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  12. 52
    The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.
    “..., their functions cannot be investigated using traditional gene targeting. Here, we generate transgenic mice...”
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  13. 53
    A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal.
    “..., a key determinant of Sertoli cell fate. Conditional gene targeting studies have identified FGFR2...”
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  14. 54
    Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression
    “... the tripeptidyl peptidase 1 (Tpp1) gene is disrupted by gene targeting, resulting in loss of detectable TPP1...”
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  15. 55
    Genetic Manipulation of the <named-content content-type="genus-species">Toxoplasma gondii</named-content> Genome by Fosmid Recombineering
    “... is typically highly favored over homologous recombination, a process required for precise gene targeting...”
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  16. 56
    Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence
    “... plays a key role in the development of metabolic syndrome. Gene targeting studies have clarified...”
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  17. 57
    Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice.
    “... in vivo, we attempted to generate mice lacking Ubiad1, a homolog of human UBIAD1, by gene targeting. Ubiad...”
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  18. 58
    Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus.
    “... protein kinases required for survival under echinocandin stress, we employed CRISPR/Cas9-mediated gene...”
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  19. 59
    Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion
    “... interspaced short palindromic repeat (CRISPR) and CRISPR-associated gene 9 (CRISPR-cas9) gene targeting. When...”
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  20. 60
    Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate-Early Genes
    “...ABSTRACT Little is known about the mechanisms of gene targeting within the nucleus and its effect...”
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