SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes

por Chisato Inoue, Chong Zhao, Yumi Tsuduki, Miyako Udono, Lixiang Wang, Masatoshi Nomura, Yoshinori Katakura
Publicado 2017

Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction

por Adam J. Dobson, Xiaoli He, Eric Blanc, Ekin Bolukbasi, Yodit Feseha, Mingyao Yang, Matthew D. W. Piper
Publicado 2018

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

por Masatoshi Hirayama, Shigeru B.H. Ko, Tetsuya Kawakita, Tomohiko Akiyama, Sravan K. Goparaju, Atsumi Soma, Yuhki Nakatake, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeto Shimmura, Kazuo Tsubota, Minoru S.H. Ko
Publicado 2017

Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

por Ryoei Uchida, Yoshimasa Saito, Kazuki Nogami, Yohei Kajiyama, Yukana Suzuki, Yasuhiro Kawase, Toshiaki Nakaoka, Toshihide Muramatsu, Masaki Kimura, Hidetsugu Saito
Publicado 2018

Erratum: Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

por Kathrin Garschall, Hanna Dellago, Martina Gáliková, Markus Schosserer, Thomas Flatt, Johannes Grillari
Publicado 2017

ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells

por Mari Yamagami, Motoyuki Otsuka, Takahiro Kishikawa, Kazuma Sekiba, Takahiro Seimiya, Eri Tanaka, Tatsunori Suzuki, Rei Ishibashi, Motoko Ohno, Kazuhiko Koike
Publicado 2018

Neuroprotective role of retinal SIRT3 against acute photo-stress

por Norimitsu Ban, Yoko Ozawa, Hideto Osada, Jonathan B. Lin, Eriko Toda, Mitsuhiro Watanabe, Kenya Yuki, Shunsuke Kubota, Rajendra S. Apte, Kazuo Tsubota
Publicado 2017

Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer’s disease

por Jaymie R. Voorhees, Matthew T. Remy, Claire M. Erickson, Laura M. Dutca, Daniel J. Brat, Andrew A. Pieper
Publicado 2019

Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells

por Mary F. Lopez, Ping Niu, Lu Wang, Maryann Vogelsang, Meenakshi Gaur, Bryan Krastins, Yueqiang Zhao, Aibek Smagul, Aliya Nussupbekova, Aikan A. Akanov, I. King Jordan, Victoria V. Lunyak
Publicado 2017

A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging

por Ha-Neui Kim, Filipa Ponte, Aaron Warren, Rebecca Ring, Srividhya Iyer, Li Han, Maria Almeida
Publicado 2021

Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis

por Claudia E. Rübe, Caroline Bäumert, Nadine Schuler, Anna Isermann, Zoé Schmal, Matthias Glanemann, Carl Mann, Harry Scherthan
Publicado 2021

Role of tubular epithelial arginase-II in renal inflammaging

por Ji Huang, Xiujie Liang, Diogo Ladeiras, Benoit Fellay, Xiu-Fen Ming, Zhihong Yang
Publicado 2021

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging

por Regina Weinmüllner, Barbara Zbiral, Adnan Becirovic, Elena Maria Stelzer, Fabian Nagelreiter, Markus Schosserer, Ingo Lämmermann, Lisa Liendl, Magdalena Lang, Lucia Terlecki-Zaniewicz, Orestis Andriotis, Michael Mildner, Bahar Golabi, Petra Waidhofer-Söllner, Karl Schedle, Gerhard Emsenhuber, Philipp J. Thurner, Erwin Tschachler, Florian Gruber, Johannes Grillari
Publicado 2020

Raloxifene for older women: a review of the literature

por Helga Hansdóttir
Publicado 2008

Granzyme B mediates impaired healing of pressure injuries in aged skin

por Christopher T. Turner, Juliana Bolsoni, Matthew R. Zeglinski, Hongyan Zhao, Tatjana Ponomarev, Katlyn Richardson, Sho Hiroyasu, Erin Schmid, Anthony Papp, David J. Granville
Publicado 2021

Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome

por Michel Bernier, Dylan Harney, Yen Chin Koay, Antonio Diaz, Abhishek Singh, Devin Wahl, Tamara Pulpitel, Ahmed Ali, Vince Guiterrez, Sarah J. Mitchell, Eun-Young Kim, John Mach, Nathan L. Price, Miguel A. Aon, David G. LeCouteur, Victoria C. Cogger, Carlos Fernandez-Hernando, John O’Sullivan, Mark Larance, Ana Maria Cuervo, Rafael de Cabo
Publicado 2020

Hearing difficulty is linked to Alzheimer’s disease by common genetic vulnerability, not shared genetic architecture

por Fatin N. Zainul Abidin, Helena R. R. Wells, Andre Altmann, Sally J. Dawson
Publicado 2021

Klotho inhibits neuronal senescence in human brain organoids

por Mohammed R. Shaker, Julio Aguado, Harman Kaur Chaggar, Ernst J. Wolvetang
Publicado 2021

Modeling transcriptomic age using knowledge-primed artificial neural networks

por Nicholas Holzscheck, Cassandra Falckenhayn, Jörn Söhle, Boris Kristof, Ralf Siegner, André Werner, Janka Schössow, Clemens Jürgens, Henry Völzke, Horst Wenck, Marc Winnefeld, Elke Grönniger, Lars Kaderali
Publicado 2021

Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation

por Li Theng Ng, Li Fang Ng, Richard Ming Yi Tang, Diogo Barardo, Barry Halliwell, Philip Keith Moore, Jan Gruber
Publicado 2020