Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent

por Joseph A. Reddy, Melissa Nelson, Christina Dircksen, Marilynn Vetzel, Theresa Johnson, Vicky Cross, Elaine Westrick, LongWu Qi, Spencer Hahn, Hari Krishna Santhapuram, Garth Parham, Kevin Wang, Jeremy F. Vaughn, Albert Felten, Michael Pugh, June Lu, Patrick Klein, Iontcho R. Vlahov, Christopher P. Leamon
Publicado 2020

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

por Mélissa Carbonneau, Laurence M. Gagné, Marie-Eve Lalonde, Marie-Anne Germain, Alena Motorina, Marie-Christine Guiot, Blandine Secco, Emma E. Vincent, Anthony Tumber, Laura Hulea, Jonathan Bergeman, Udo Oppermann, Russell G. Jones, Mathieu Laplante, Ivan Topisirovic, Kevin Petrecca, Marc-Étienne Huot, Frédérick A. Mallette
Publicado 2016

Modulating supramolecular binding of carbon dioxide in a redox-active porous metal-organic framework

por Zhenzhong Lu, Harry G. W. Godfrey, Ivan da Silva, Yongqiang Cheng, Mathew Savage, Floriana Tuna, Eric J. L. McInnes, Simon J. Teat, Kevin J. Gagnon, Mark D. Frogley, Pascal Manuel, Svemir Rudić, Anibal J. Ramirez-Cuesta, Timothy L. Easun, Sihai Yang, Martin Schröder
Publicado 2017

Correction: Corrigendum: Quantitative real-time imaging of glutathione

por Xiqian Jiang, Jianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Feng Li, Kevin R. MacKenzie, Allan Chris M. Ferreon, Fan Xia, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang
Publicado 2017

Quantitative real-time imaging of glutathione

por Xiqian Jiang, Jianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Feng Li, Kevin R. MacKenzie, Allan Chris M. Ferreon, Fan Xia, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang
Publicado 2017

Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer

por Kyung-min Lee, Angel L. Guerrero-Zotano, Alberto Servetto, Dhivya R. Sudhan, Chang-Ching Lin, Luigi Formisano, Valerie M. Jansen, Paula González-Ericsson, Melinda E. Sanders, Thomas P. Stricker, Ganesh Raj, Kevin M. Dean, Reto Fiolka, Lewis C. Cantley, Ariella B. Hanker, Carlos L. Arteaga
Publicado 2020

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

por Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips, Jonathan M. Kurie
Publicado 2018

Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates

por Jennifer M. Brannan, Shihua He, Katie A. Howell, Laura I. Prugar, Wenjun Zhu, Hong Vu, Sergey Shulenin, Shweta Kailasan, Henna Raina, Gary Wong, Md Niaz Rahim, Logan Banadyga, Kevin Tierney, Xuelian Zhao, Yuxing Li, Frederick W. Holtsberg, John M. Dye, Xiangguo Qiu, M. Javad Aman
Publicado 2019

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

por Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang
Publicado 2020

Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation

por Victoria Cotero, Ying Fan, Tea Tsaava, Adam M. Kressel, Ileana Hancu, Paul Fitzgerald, Kirk Wallace, Sireesha Kaanumalle, John Graf, Wayne Rigby, Tzu-Jen Kao, Jeanette Roberts, Chitresh Bhushan, Suresh Joel, Thomas R. Coleman, Stavros Zanos, Kevin J. Tracey, Jeffrey Ashe, Sangeeta S. Chavan, Christopher Puleo
Publicado 2019

Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

por Kevin Alicea-Torres, Emilio Sanseviero, Jun Gui, Jinyun Chen, Filippo Veglia, Qiujin Yu, Laxminarasimha Donthireddy, Andrew Kossenkov, Cindy Lin, Shuyu Fu, Charles Mulligan, Brian Nam, Gregory Masters, Fred Denstman, Joseph Bennett, Neil Hockstein, Agnieszka Rynda-Apple, Yulia Nefedova, Serge Y. Fuchs, Dmitry I. Gabrilovich
Publicado 2021

Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

por Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, Michael B. Yaffe
Publicado 2020

SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia

por John Everett, Pascha Hokama, Aoife M. Roche, Shantan Reddy, Young Hwang, Lyanna Kessler, Abigail Glascock, Yize Li, Jillian N. Whelan, Susan R. Weiss, Scott Sherrill-Mix, Kevin McCormick, Samantha A. Whiteside, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Ronald G. Collman, Frederic Bushman
Publicado 2021

Distinct magneto-Raman signatures of spin-flip phase transitions in CrI3

por Amber McCreary, Thuc T. Mai, Franz G. Utermohlen, Jeffrey R. Simpson, Kevin F. Garrity, Xiaozhou Feng, Dmitry Shcherbakov, Yanglin Zhu, Jin Hu, Daniel Weber, Kenji Watanabe, Takashi Taniguchi, Joshua E. Goldberger, Zhiqiang Mao, Chun Ning Lau, Yuanming Lu, Nandini Trivedi, Rolando Valdés Aguilar, Angela R. Hight Walker
Publicado 2020

Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

por Elizabeth D. Luczak, Yuejin Wu, Jonathan M. Granger, Mei-ling A. Joiner, Nicholas R. Wilson, Ashish Gupta, Priya Umapathi, Kevin R. Murphy, Oscar E. Reyes Gaido, Amin Sabet, Eleonora Corradini, Wen-Wei Tseng, Yibin Wang, Albert J. R. Heck, An-Chi Wei, Robert G. Weiss, Mark E. Anderson
Publicado 2020

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

por Charles P. Couturier, Shamini Ayyadhury, Phuong U. Le, Javad Nadaf, Jean Monlong, Gabriele Riva, Redouane Allache, Salma Baig, Xiaohua Yan, Mathieu Bourgey, Changseok Lee, Yu Chang David Wang, V. Wee Yong, Marie-Christine Guiot, Hamed Najafabadi, Bratislav Misic, Jack Antel, Guillaume Bourque, Jiannis Ragoussis, Kevin Petrecca
Publicado 2020

Schistosome infection in Senegal is associated with different spatial extents of risk and ecological drivers for Schistosoma haematobium and S. mansoni.

por Isabel J Jones, Susanne H Sokolow, Andrew J Chamberlin, Andrea J Lund, Nicolas Jouanard, Lydie Bandagny, Raphaël Ndione, Simon Senghor, Anne-Marie Schacht, Gilles Riveau, Skylar R Hopkins, Jason R Rohr, Justin V Remais, Kevin D Lafferty, Armand M Kuris, Chelsea L Wood, Giulio De Leo
Publicado 2021

Differential pathogenesis of closely related 2018 Nigerian outbreak clade III Lassa virus isolates.

por Derek R Stein, Bryce M Warner, Jonathan Audet, Geoff Soule, Vinayakumar Siragam, Patrycja Sroga, Bryan D Griffin, Anders Leung, Allen Grolla, Kevin Tierney, Alix Albietz, Darwyn Kobasa, Abdulmajid S Musa, Adama Ahmad, Afolabi M Akinpelu, Nwando Mba, Rebecca Rosenke, Dana P Scott, Greg Saturday, Chikwe Ihekweazu, David Safronetz
Publicado 2021

Oncolytic virus-derived type I interferon restricts CAR T cell therapy

por Laura Evgin, Amanda L. Huff, Phonphimon Wongthida, Jill Thompson, Tim Kottke, Jason Tonne, Matthew Schuelke, Katayoun Ayasoufi, Christopher B. Driscoll, Kevin G. Shim, Pierce Reynolds, Dileep D. Monie, Aaron J. Johnson, Matt Coffey, Sarah L. Young, Gary Archer, John Sampson, Jose Pulido, Luis Sanchez Perez, Richard Vile
Publicado 2020

Author Correction: Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

por Charles P. Couturier, Shamini Ayyadhury, Phuong U. Le, Javad Nadaf, Jean Monlong, Gabriele Riva, Redouane Allache, Salma Baig, Xiaohua Yan, Mathieu Bourgey, Changseok Lee, Yu Chang David Wang, V. Wee Yong, Marie-Christine Guiot, Hamed Najafabadi, Bratislav Misic, Jack Antel, Guillaume Bourque, Jiannis Ragoussis, Kevin Petrecca
Publicado 2020