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  1. 3781
    Application of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1).
    por Shu Liu, Rao Fu, Li-Hua Zhou, Sheng-Ping Chen
    Publicado 2012
    “... quantitative statistical manner and would appear to have considerable potential for chemical screening...”
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  2. 3782
    Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies.
    “... variants play a role in susceptibility to AD in a gain-of-function manner. Our findings provide a new...”
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  3. 3783
    Environmental factors affecting the expression of pilAB as well as the proteome and transcriptome of the grass endophyte Azoarcus sp. strain BH72.
    “... appears to be regulated in a population density-dependent manner.<h4>Methodology/principal findings</h4...”
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  4. 3784
    Augmenter of liver regeneration (alr) promotes liver outgrowth during zebrafish hepatogenesis.
    “... defects and early embryonic death in an alr sequence-dependent manner. These results suggest that alr...”
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  5. 3785
    MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth.
    “... of yeast cells, suggesting that Mho1 might be acting in a dominant negative manner. Taken together, our...”
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  6. 3786
    Skeletal adaptation to intramedullary pressure-induced interstitial fluid flow is enhanced in mice subjected to targeted osteocyte ablation.
    “...-specific manner. In pressure-loaded limbs, transgenic mice displayed similar or significantly enhanced...”
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  7. 3787
    Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo.
    “... that the oligodendrocytes' cytoplasm-filled processes initially spiral around the axon in a corkscrew-like manner...”
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  8. 3788
    ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA.
    “... dramatic neurite collapse in a dose-dependent manner and this effect was about 500 fold more potent than...”
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  9. 3789
    CRISPR interference directs strand specific spacer acquisition.
    “... acquisition events in a strand specific manner.<h4>Conclusions</h4>The E. coli Type I-E CRISPR/Cas system...”
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  10. 3790
    The effect of all extremity high intensity interval training on athero-protective factors and endothelial function in overweight and obese women
    “... ergometers in a simultaneous manner on 10 weeks of four sessions of 40 min each. FGF21, adiponectin, NO, FMD...”
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  11. 3791
    ASEAN and EAEU: Cooperation Problems and Prospects
    “... by creating an «airbag», in a manner of speaking, to protect a particular regional integration union from...”
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  12. 3792
    Electric Cell-Substrate Impedance Sensing To Monitor Viral Growth and Study Cellular Responses to Infection with Alphaherpesviruses in Real Time
    “... alphaherpesvirus infections in real time and in an objective and reproducible manner....”
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  13. 3793
    Establishment of a Rapid Detection System for ISG20-Dependent SARS-CoV-2 Subreplicon RNA Degradation Induced by Interferon-α
    “...-3008 suppressed SARS-CoV-2 subreplicon RNA in a dose-dependent manner, with IC50 values of 193 IU/mL...”
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  14. 3794
    Histamine Increases Th2 Cytokine-Induced CCL18 Expression in Human M2 Macrophages
    “... more pronounced manner, IL-4 and IL-13, also upregulated CCL18. Histamine increased the cytokine...”
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  15. 3795
    Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in <i>Sephs1<sup>−/−</sup></i> Mice
    “... that the gene sets related to redox homeostasis and apoptosis were gradually enriched in a time-dependent manner...”
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  16. 3796
    Cancer-Cell-Derived IgG and Its Potential Role in Tumor Development
    “... of about 90% on the amino acid level, each subclass possesses a unique manner of antigen binding and immune...”
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  17. 3797
    A Hybrid Finite Element—Machine Learning Backward Training Approach to Analyze the Optimal Machining Conditions
    “... for manufacturers to have some manner of determining whether the inputs will achieve the desired outputs within...”
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  18. 3798
    Insights into Intra-Tumoral Heterogeneity: Transcriptional Profiling of Chemoresistant MPM Cell Subpopulations Reveals Involvement of NFkB and DNA Repair Pathways and Contributes a Prognostic Signature
    “... in vitro and in vivo. We identified 924 genes modulated in a statistically significant manner as a function...”
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  19. 3799
    The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration
    “... length-related manner. The mRNA expression of cytokines, including tumor necrosis factor alpha...”
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  20. 3800
    Palmitic acid increases apoptosis by mitochondrial pathway in hepatocytes with growth hormone deficiency
    “... the survival rate of the L02 cells in a concentration-dependent manner. Compared with the control group...”
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