Mostrando 21 - 40 Resultados de 76 Para Buscar '"Mdm2"', tiempo de consulta: 0.31s Limitar resultados
  1. 21
    K-Ras-ERK1/2 accelerates lung cancer cell development via mediating H3K18ac through the MDM2-GCN5-SIRT7 axis
    “... detected by RT-PCR and ChIP assays. The regulatory functions of SIRT7, GCN5 and MDM2 in Ras-ERK1/2...”
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  2. 22
    Cáncer gástrico y regulación del crecimiento tumoral.: Estudio de marcadores de proliferación celular y del complejo proteínas p53/p21WAF1/CIP1/mdm-2
    “...Background: p53/p21WAF1/CIP1 and mdm-2 proteins play an important role in cell cycle regulation...”
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  3. 23
    Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage.
    “...Tumor suppressor protein p53 is regulated by two structurally homologous proteins, Mdm2 and MdmX...”
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  4. 24
    Human monocyte-derived type 1 and 2 macrophages recognize Ara h 1, a major peanut allergen, by different mechanisms
    “...-inflammatory model) and type 2 (hMDM2: anti-inflammatory model). hMDM1 and hMDM2 predominantly produced pro...”
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  5. 25
    Informe de la Segunda Reunión de la Mesa Directiva de la Conferencia Regional sobre la Integración de la Mujer en el Desarrollo Económico y Social de América Latina y el Caribe
    Publicado 2014
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  6. 26
    Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
    “...MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here...”
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  7. 27
    Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs
    “.... In the present study, taking MDM2 as an example, a novel amplified luminescent proximity homogeneous assay...”
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  8. 28
    Attenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 function.
    “..., human sarcoma cell lines (n = 9) with different TP53 and MDM2 status were studied for their sensitivity...”
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  9. 29
    p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors.
    “... progression in the metastatic setting. Upregulation of p53 by MDM2 inhibitors has been shown to induce...”
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  10. 30
    p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.
    “... modulators, particularly the p53 negative regulators MDM2 and MDM4.<h4>Methodology/principal findings</h4...”
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  11. 31
    Report of the Second Meeting of the Presiding Officers of the Regional Conference on the Integration of Women into the Economic and Social Development of Latin America and the Caribbean
    Publicado 2017
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  12. 32
    The Basally Expressed p53-Mediated Homeostatic Function
    por Isha Nagpal, Zhi-Min Yuan
    Publicado 2021
    “... expression of the critical p53 E3 ligase MDM2 or MDM2/MDMX is found in many human cancers. Likewise, the HPV...”
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  13. 33
    ALKBH5-mediated m6A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling
    “...15-AS1 combined with KCNK15 5’UTR to inhibit KCNK15 translation. Moreover, KCNK15-AS1 recruited MDM2...”
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  14. 34
    A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins
    “..., but not in the receptor for activated C kinase or the RING E3 ligases Mdm2 and Cop1. Collectively, the data suggest...”
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  15. 35
    The potential role of As-sumo-1 in the embryonic diapause process and early embryo development of Artemia sinica.
    “... and the location of As-sumo-1 were investigated. SUMO-1, p53, Mdm2, Caspase-1, Cyclin B and Cyclin E proteins were...”
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  16. 36
    p53 dynamics vary between tissues and are linked with radiation sensitivity
    “... in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity....”
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  17. 37
    Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
    “... is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts...”
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  18. 38
    Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
    “... facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis....”
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  19. 39
    C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
    “... with MDM2 and facilitates p53 accumulation and activation of its downstream targets....”
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  20. 40
    BRD4-mediated repression of p53 is a target for combination therapy in AML
    “...MDM2 and BET inhibitors have shown efficacy in AML treatment. Here, the authors show that the two...”
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