A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

por Stefan Arenz, Lars V. Bock, Michael Graf, C. Axel Innis, Roland Beckmann, Helmut Grubmüller, Andrea C. Vaiana, Daniel N. Wilson
Publicado 2016

A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

por Jungyoon Kim, Sujung Yoon, Suji Lee, Haejin Hong, Eunji Ha, Yoonji Joo, Eun Hee Lee, In Kyoon Lyoo
Publicado 2020

Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals

por Taylor F. Minckley, Chen Zhang, Dylan H. Fudge, Anna M. Dischler, Kate D. LeJeune, Haoxing Xu, Yan Qin
Publicado 2019

Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

por Qi Han, Josue D. Ordaz, Nai-Kui Liu, Zoe Richardson, Wei Wu, Yongzhi Xia, Wenrui Qu, Ying Wang, Heqiao Dai, Yi Ping Zhang, Christopher B. Shields, George M. Smith, Xiao-Ming Xu
Publicado 2019

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

por Naoto Muraoka, Kaori Nara, Fumiya Tamura, Hidenori Kojima, Hiroyuki Yamakawa, Taketaro Sadahiro, Kazutaka Miyamoto, Mari Isomi, Sho Haginiwa, Hidenori Tani, Shota Kurotsu, Rina Osakabe, Satoru Torii, Shigeomi Shimizu, Hideyuki Okano, Yukihiko Sugimoto, Keiichi Fukuda, Masaki Ieda
Publicado 2019

Boron-mediated sequential alkyne insertion and C–C coupling reactions affording extended π-conjugated molecules

por Yoshiaki Shoji, Naoki Tanaka, Sho Muranaka, Naoki Shigeno, Haruka Sugiyama, Kumiko Takenouchi, Fatin Hajjaj, Takanori Fukushima
Publicado 2016

Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection

por Carolina G. O. Lucas, Jamil Z. Kitoko, Fabricio M. Ferreira, Vinicius G. Suzart, Michelle P. Papa, Sharton V. A. Coelho, Cecilia B. Cavazzoni, Heitor A. Paula-Neto, Priscilla C. Olsen, Akiko Iwasaki, Renata M. Pereira, Pedro M. Pimentel-Coelho, Andre M. Vale, Luciana B. de Arruda, Marcelo T. Bozza
Publicado 2018

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

por Longfei Deng, Pengbo Yao, Le Li, Fansen Ji, Shuang Zhao, Chang Xu, Xun Lan, Peng Jiang
Publicado 2020

Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue

por Vanessa Pellegrinelli, Vivian J. Peirce, Laura Howard, Samuel Virtue, Dénes Türei, Martina Senzacqua, Andrea Frontini, Jeffrey W. Dalley, Antony R. Horton, Guillaume Bidault, Ilenia Severi, Andrew Whittle, Kamal Rahmouni, Julio Saez-Rodriguez, Saverio Cinti, Alun M. Davies, Antonio Vidal-Puig
Publicado 2018

Publisher Correction: Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system

por Tong-Tong Pei, Hao Li, Xiaoye Liang, Zeng-Hang Wang, Guangfeng Liu, Li-Li Wu, Haeun Kim, Zhiping Xie, Ming Yu, Shuangjun Lin, Ping Xu, Tao G. Dong
Publicado 2020

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

por Kristian W. Pajtler, Yiju Wei, Konstantin Okonechnikov, Patricia B. G. Silva, Mikaella Vouri, Lei Zhang, Sebastian Brabetz, Laura Sieber, Melissa Gulley, Monika Mauermann, Tatjana Wedig, Norman Mack, Yuka Imamura Kawasawa, Tanvi Sharma, Marc Zuckermann, Felipe Andreiuolo, Eric Holland, Kendra Maass, Huiqin Körkel-Qu, Hai-Kun Liu, Felix Sahm, David Capper, Jens Bunt, Linda J. Richards, David T. W. Jones, Andrey Korshunov, Lukas Chavez, Peter Lichter, Mikio Hoshino, Stefan M. Pfister, Marcel Kool, Wei Li, Daisuke Kawauchi
Publicado 2019

EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

por Yingqian Li, Yoshimasa Takahashi, Shin-ichiro Fujii, Yang Zhou, Rongjian Hong, Akari Suzuki, Takeshi Tsubata, Koji Hase, Ji-Yang Wang
Publicado 2016

Author Correction: Split intein-mediated selection of cells containing two plasmids using a single antibiotic

por Navaneethan Palanisamy, Anna Degen, Anna Morath, Jara Ballestin Ballestin, Claudia Juraske, Mehmet Ali Öztürk, Georg A. Sprenger, Jung-Won Youn, Wolfgang W. Schamel, Barbara Di Ventura
Publicado 2020

Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells

por Claire E. O’Leary, Christopher R. Riling, Lynn A. Spruce, Hua Ding, Suresh Kumar, Guoping Deng, Yuhong Liu, Steven H. Seeholzer, Paula M. Oliver
Publicado 2016

A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants

por Zhen Lin, Yuan Li, Zhengjing Zhang, Xiaolei Liu, Chuan-Chih Hsu, Yanyan Du, Tian Sang, Chen Zhu, Yubei Wang, Viswanathan Satheesh, Pritu Pratibha, Yang Zhao, Chun-Peng Song, W. Andy Tao, Jian-Kang Zhu, Pengcheng Wang
Publicado 2020

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

por Rink-Jan Lohman, Johan K. Hamidon, Robert C. Reid, Jessica A. Rowley, Mei-Kwan Yau, Maria A. Halili, Daniel S. Nielsen, Junxian Lim, Kai-Chen Wu, Zhixuan Loh, Anh Do, Jacky Y. Suen, Abishek Iyer, David P. Fairlie
Publicado 2017

The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis

por Cong Qiu, Yuewen Wang, Haige Zhao, Lingfeng Qin, Yanna Shi, Xiaolong Zhu, Lin Song, Xiaofei Zhou, Jian Chen, Hong Zhou, Haifeng Zhang, George Tellides, Wang Min, Luyang Yu
Publicado 2017

mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

por Victor H. Villar, Tra Ly Nguyen, Vanessa Delcroix, Silvia Terés, Marion Bouchecareilh, Bénédicte Salin, Clément Bodineau, Pierre Vacher, Muriel Priault, Pierre Soubeyran, Raúl V. Durán
Publicado 2017

Author Correction: Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells

por Marcin Łyszkiewicz, Natalia Ziętara, Laura Frey, Ulrich Pannicke, Marcel Stern, Yanshan Liu, Yanxin Fan, Jacek Puchałka, Sebastian Hollizeck, Ido Somekh, Meino Rohlfs, Tuğba Yilmaz, Ekrem Ünal, Musa Karakukcu, Türkan Patiroğlu, Christina Kellerer, Ebru Karasu, Karl-Walter Sykora, Atar Lev, Amos Simon, Raz Somech, Joachim Roesler, Manfred Hoenig, Oliver T. Keppler, Klaus Schwarz, Christoph Klein
Publicado 2020

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

por Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang
Publicado 2017