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  1. 5081
    RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.
    “...11 affect the localization of a mediator of both gluconeogenesis and glycolysis regulation, CRTC2...”
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  2. 5082
    A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma
    “...BAY-876 is an effective antagonist of the Glucose transporter type 1 (GLUT1) receptor, a mediator...”
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  3. 5083
    COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas
    “...5A1 and found that the percentages of the dendritic cells, which were known as the central mediator...”
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  4. 5084
    Hypoxia negatively regulates antimetastatic PEDF in melanoma cells by a hypoxia inducible factor-independent, autophagy dependent mechanism.
    “... of the hypoxia inducible factor (HIF), a key mediator of the adaptation to hypoxia. Decreased PEDF protein...”
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  5. 5085
    Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation.
    “... stem cells (MSCs). We and others also showed that GILZ is a GC effecter and mediates GC anti...”
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  6. 5086
    Molecular mechanism underlying persistent induction of LCN2 by lipopolysaccharide in kidney fibroblasts.
    por Trevor Glaros, Yan Fu, Jianhua Xing, Liwu Li
    Publicado 2012
    “...The neutrophil gelatinase-associated lipocalin 2 (LCN2) is a critical inflammatory mediator...”
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  7. 5087
    Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.
    “... in WKY animals independent of a reduction in colonic rat mast cell mediator release. We further...”
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  8. 5088
    Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes
    “.... Lysophosphatidic acid (LPA), a known lipid mediator on induction of actin polymerization, significantly increased...”
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  9. 5089
    Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
    “... in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty...”
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  10. 5090
    Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy
    “... blocks the production of sphingosine-1-phosphate(S1P), a mediator of cellular events during inflammatory...”
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  11. 5091
    BNIP3L promotes cardiac fibrosis in cardiac fibroblasts through [Ca2+]i-TGF-β-Smad2/3 pathway
    “... in vitro and in vivo. These results reveal that BNIP3L is a novel mediator of pressure overload-induced...”
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  12. 5092
    The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis
    “...Abstract The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between...”
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  13. 5093
    Polyfunctional natural killer cells with a low activation profile in response to Toll-like receptor 3 activation in HIV-1-exposed seronegative subjects
    “...Abstract Natural killer (NK) cells are the main mediator of the cytotoxic response in innate...”
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  14. 5094
    Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells
    “...Abstract This report identifies mitochondrial DNA (mtDNA) as a target and active mediator...”
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  15. 5095
    Xiaoshuan enteric-coated capsule alleviates cognitive impairment by enhancing hippocampal glucose metabolism, hemodynamics and neuroplasticity of rat with chronic cerebral hypoperfusion
    “... including protein kinase B (AKT), glycogen synthase kinase-3β (GSK-3β) and collapsin response mediator...”
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  16. 5096
    Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance
    “... of mental illness. We have shown that prostaglandin (PG) E2, an arachidonic acid-derived lipid mediator...”
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  17. 5097
    Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy
    “... identified GTP cyclohydrolase (GCH1) and folate metabolism as candidate mediators of α-synuclein...”
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  18. 5098
    Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis
    “...-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. BML-111 (5...”
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  19. 5099
    Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury
    “... identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6...”
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  20. 5100
    Posttraumatic stress symptoms, dissociation, and alexithymia in an Italian sample of flood victims
    “... regression showed that peritraumatic dissociation plays a mediator role between alexithymia, dissociation...”
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