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  1. 6001
    FBXO22 degrades nuclear PTEN to promote tumorigenesis
    “... is more susceptible to ubiquitin-mediated proteasomal degradation than cytoplasmic PTEN, and identify FBXO...”
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  2. 6002
    Speed dependent descending control of freezing behavior in Drosophila melanogaster
    “... and identify the involvement of a pair of neurons in mediating the behavior....”
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  3. 6003
    Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania
    “... kinase (CDPK1) can mediate resistance to paromomycin by affecting translation....”
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  4. 6004
    RNA editing is abundant and correlates with task performance in a social bumblebee
    “... care and foraging. Here the authors report a high level of ADAR-mediated RNA editing in the bumblebee...”
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  5. 6005
    Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
    “...Claspin mediates the transmission of a replication-stress signal from ATR to Chk1 and is necessary...”
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  6. 6006
    Expanding the limits of the second genetic code with ribozymes
    “... polymerization in vitro. Here the authors deduce design rules of Flexizyme-mediated tRNA acylation that more...”
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  7. 6007
    De novo evolved interference competition promotes the spread of biofilm defectors
    “... evolve the ability to better incorporate into biofilms via phage-mediated interference....”
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  8. 6008
    Timely regulated sorting from early to late endosomes is required to maintain cerebellar long-term depression
    “...Long term depression (LTD) of the cerebellum is known to be mediated by postsynaptic trafficking...”
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  9. 6009
    Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
    “...Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence...”
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  10. 6010
    A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome
    “...During embryogenesis, the cytoplasmic protein Myomarker (MYMK) mediates muscle fibre formation...”
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  11. 6011
    A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
    “...The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use...”
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  12. 6012
    ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
    “...ABC exporters mediate the translocation of cytotoxic compounds to the cell exterior via ATP...”
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  13. 6013
    CIC protein instability contributes to tumorigenesis in glioblastoma
    “... activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant...”
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  14. 6014
    Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
    “... by complement for microglial phagocytosis, thus mediating changes in social behavior....”
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  15. 6015
    Electric-field control of skyrmions in multiferroic heterostructure via magnetoelectric coupling
    “... of skyrmions through strain-mediated magnetoelectric coupling in multiferroic heterostructures....”
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  16. 6016
    Frustrated flexibility in metal-organic frameworks
    “... and structurally degenerate amorphous states mediated by competing intra-framework forces....”
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  17. 6017
    Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
    “... dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show...”
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  18. 6018
    MANF regulates hypothalamic control of food intake and body weight
    “...MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response...”
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  19. 6019
    Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
    “...-mediated endocytosis with a dynamin GTPase inhibitor overcomes chemoresistance of LSC....”
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  20. 6020
    Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
    “... and report nanoparticle-mediated relaxin gene therapy to mitigate fibrosis and liver metastasis....”
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