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  1. 6761
    Expansion of a core regulon by transposable elements promotes Arabidopsis chemical diversity and pathogen defense
    por Brenden Barco, Yoseph Kim, Nicole K. Clay
    Publicado 2019
    “.... Here, the authors show that EPCOT3, a retrotransposonderived enhancer, mediates WRKY33-binding...”
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  2. 6762
    PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
    “...-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated...”
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  3. 6763
    Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
    “... mediated by Semaphorin-Plexin signalling and develop an optogenetic tool for Plexin-B1 to show how...”
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  4. 6764
    Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
    “...In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars...”
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  5. 6765
    ASK1 inhibits browning of white adipose tissue in obesity
    “...Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis...”
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  6. 6766
    Bidirectional contraction of a type six secretion system
    por Piotr Szwedziak, Martin Pilhofer
    Publicado 2019
    “... proteins that mediate cell-cell interactions. Here, Szwedziak & Pilhofer show that both ends of a T6SS can...”
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  7. 6767
    Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
    “... expression of intestinal and pancreatic genes mediating food digestion and uptake through IL-22, which...”
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  8. 6768
    The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
    “... show that GPR120 is upregulated in brown fat in cold-exposed mice, and mediates thermogenic activation...”
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  9. 6769
    STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
    “...Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy...”
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  10. 6770
    Super-complexes of adhesion GPCRs and neural guidance receptors
    “...FLRT proteins are known to interact with Lphns and Unc5s, mediating cell adhesion and repulsion...”
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  11. 6771
    Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
    “...Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell...”
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  12. 6772
    PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
    “... facilitates substrate binding by the complex and elucidate the allosteric mechanism of PALI1- mediated PRC2...”
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  13. 6773
    USP21 prevents the generation of T-helper-1-like Treg cells
    “... FOXP3 by mediating its deubiquitination and helps to maintain the expression of Treg signature genes...”
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  14. 6774
    Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
    “...Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states...”
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  15. 6775
    Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
    “..., here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes...”
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  16. 6776
    Epsin and Sla2 form assemblies through phospholipid interfaces
    “... proteins epsin and Sla2 form complexes mediated through phosphatidylinositol 4,5-bisphosphate interfaces...”
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  17. 6777
    αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
    “...) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody production....”
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  18. 6778
    Specialized odorant receptors in social insects that detect cuticular hydrocarbon cues and candidate pheromones
    “...Cuticular hydrocarbons (CHC) mediate the interactions between individuals in eusocial insects...”
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  19. 6779
    ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
    “...NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying...”
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  20. 6780
    FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
    “..., regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden...”
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