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  1. 11501
    Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy
    por Jakub Kralik, Sonja Kleinlogel
    Publicado 2021
    “... and the intracellular domains of the metabotropic glutamate receptor 6 (mGluR6), which naturally mediates light...”
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  2. 11502
    Gene Therapy Strategy for Alzheimer’s and Parkinson’s Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells
    “...). As gangliosides mediate the initial binding step of these amyloid proteins to lipid rafts of the brain cell...”
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  3. 11503
    Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
    “...-osteoclasts suggested a metabolic rewiring of mitochondria. Taken together, targeting radiation-mediated...”
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  4. 11504
    Emerging Importance of Tyrosine Kinase Inhibitors against Cancer: Quo Vadis to Cure?
    “... a promising therapeutic target to cure cancer. A recent report shows that TKIs are vital mediators...”
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  5. 11505
    Targeting Oxidative Stress: Novel Coumarin-Based Inverse Agonists of GPR55
    “... in the inhibition of prostaglandin E<sub>2</sub>. However, the antioxidative effects mediated by GPR55 were...”
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  6. 11506
    Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene
    “... of nonsense mutations: SMG1i to protect CFTR mRNA from nonsense-mediated decay (NMD), G418 and ELX-02...”
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  7. 11507
    Structural and Functional Characterization of One Unclassified Glutathione S-Transferase in Xenobiotic Adaptation of <i>Leptinotarsa decemlineata</i>
    “... that are mainly associated with xenobiotic or stress adaptation. GST-mediated xenobiotic adaptation takes place...”
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  8. 11508
    Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?
    “...Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads...”
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  9. 11509
    Role of Caryophyllane Sesquiterpenes in the Entourage Effect of Felina 32 Hemp Inflorescence Phytocomplex in Triple Negative MDA-MB-468 Breast Cancer Cells
    “... mediated by a CB2 receptor activation. Cannabidiol was the main cytotoxic constituent, although low levels...”
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  10. 11510
    Virus-induced gene silencing (VIGS) in Chinese narcissus and its use in functional analysis of NtMYB3
    “..., the VIGS system mediated by Tobacco rattle virus (TRV) has been successfully established in many plant...”
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  11. 11511
    New Therapeutic Strategy for Overcoming Multidrug Resistance in Cancer Cells with Pyrazolo[3,4-<i>d</i>]pyrimidine Tyrosine Kinase Inhibitors
    “... models. Therefore, pyrazolo[3,4-<i>d</i>]pyrimidines with potential for reversing P-gp-mediated MDR even...”
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  12. 11512
    Laser Immunotherapy: A Potential Treatment Modality for Keratinocyte Carcinoma
    “... destruction and laser-assisted drug delivery to laser-mediated immune modulation. Evidence indicates...”
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  13. 11513
    Targeting of HSP70/HSF1 Axis Abrogates In Vitro Ibrutinib-Resistance in Chronic Lymphocytic Leukemia
    “... heat shock factor 1 (HSF1) play a role in mediating the survival and progression of CLL, as well...”
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  14. 11514
    Protective mitochondrial fission induced by stress-responsive protein GJA1-20k
    “... recruitment of actin. Interestingly, GJA1-20k mediated fission is independent of canonical Dynamin-Related...”
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  15. 11515
    An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants
    “... also act as a double-edged sword, and dysregulated TLR responses may enhance immune-mediated pathology...”
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  16. 11516
    Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
    “... of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable...”
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  17. 11517
    The paracrine effects of adipocytes on lipid metabolism in doxorubicin-treated triple negative breast cancer cells
    “... doxorubicin treatment resistance, by increasing the utilization of inflammatory mediators and inhibiting...”
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  18. 11518
    Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa
    “... have been suggested to play an important role in the pathogenesis of chronic immune-mediated...”
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  19. 11519
    Tumor-Derived Small Extracellular Vesicles Induce Pro-Inflammatory Cytokine Expression and PD-L1 Regulation in M0 Macrophages via IL-6/STAT3 and TLR4 Signaling Pathways
    “... convergent mechanism for SEV-mediated PD-L1 expression. Overall, these preliminary data suggest that SEVs...”
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  20. 11520
    Referral Patterns in Oral Medicine: A Retrospective Analysis of an Oral Medicine University Center in Southern Italy
    “...% by physicians, and 9.7% did not have a referral. The most common diseases for referral were immune-mediated...”
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