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  1. 12001
    Combination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1
    “... mediated by the mammalian target of rapamycin (mTOR)/sphingosine-kinase-1 (SK1) pathway. Here we...”
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  2. 12002
    Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease
    por Tanya M. Laidlaw
    Publicado 2018
    “...-phenotyped patients with AERD have confirmed that both proinflammatory lipid mediators, predominantly cysLTs...”
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  3. 12003
    Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation
    “... an unexpected effect of oxygen deprivation on platelet aggregation mediated by the fibrinogen receptor integrin...”
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  4. 12004
    A Meloidogyne incognita effector MiISE5 suppresses programmed cell death to promote parasitism in host plant
    “... susceptible to M. incognita. Inversely, the tobacco rattle virus (TRV)-mediated silence of MiISE5 decreased...”
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  5. 12005
    Allatostatin C modulates nociception and immunity in Drosophila
    “... neuronal role in mediating these processes during homeostatic conditions. Further examination...”
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  6. 12006
    Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity
    “..., indicating the elevated amount of alveolar macrophage-derived CCL24 inhibited γδT cell mediated anti-tumor...”
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  7. 12007
    Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types
    “... expression group in HCC, suggesting the potential role of KIF4A in mediating tumor initiation and progression...”
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  8. 12008
    Genetic variants in the transcription regulatory region of MEGF10 are associated with autism in Chinese Han population
    “... of the apoptotic engulfment pathway, mediates axon pruning and synapse elimination during brain development...”
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  9. 12009
    The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis
    “... and differential localization of Cdc42 and Rac1. The downstream Rho GTPase effectors mediating actin polymerization...”
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  10. 12010
    SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+oscillations in β cell networks
    “...Abstract SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release...”
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  11. 12011
    Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway
    “... and E7 are essential for oncogenic cell transformation. E6 mediates the degradation of the tumor...”
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  12. 12012
    Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop
    “... that is important in substrate binding. In this report, we identify Abl-mediated phosphorylation of a highly...”
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  13. 12013
    Complete alanine scanning of the Escherichia coli RbsB ribose binding protein reveals residues important for chemoreceptor signaling and periplasmic abundance
    “... the influence of individual residues on RbsB-mediated signaling in a near complete library of alanine...”
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  14. 12014
    Melon13-lipoxygenase CmLOX18 may be involved in C6 volatiles biosynthesis in fruit
    “... the CmLOX18 gene was transgenically expressed in tomato via Agrobacterium tumefaciens-mediated...”
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  15. 12015
    Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
    “... shape brain and behaviour. Current research is therefore increasingly focusing on mechanisms mediating...”
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  16. 12016
    Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models
    “... virus (AAV)-mediated overexpression of the three predominant human ApoE isoforms within astrocytes...”
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  17. 12017
    Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy
    “... kidney diseases via different mechanisms such as immune-mediated injury, kidney cell injury from a direct...”
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  18. 12018
    The homology gene BtDnmt1 is Essential for Temperature Tolerance in Invasive Bemisia tabaci Mediterranean Cryptic Species
    “... to temperature stress. Epigenetic mechanisms play important roles in mediating ecological plasticity...”
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  19. 12019
    Two dopamine D2-like receptor genes from the silkworm (Bombyx mori) and their evolutionary history in metazoan
    “... functions. Dopaminergic signaling is mediated through two classes of dopamine receptors, D1-like and D2-like...”
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  20. 12020
    Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease
    “... was shown to be deacetylated by HDAC1, which regulates the capacity of TAF9 to mediate fatty acid β...”
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