Genome-wide CRISPR-Cas9 screens identify mechanisms of BET bromodomain inhibitor sensitivity

por David Estoppey, Gabi Schutzius, Christian Kolter, Adrian Salathe, Tiffany Wunderlin, Amandine Meyer, Florian Nigsch, Tewis Bouwmeester, Dominic Hoepfner, Susan Kirkland
Publicado 2021

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

por Bo Wei, Yini Zhu, Peng Yang, Yong Han, Suyun Wang, Xiaomei Wang, Shuai Xia, Xiaoguang Song, Zhongling Zhang, Sheng Wang, Philippe Rondard, Jean-Philippe Pin, Xinnong Jiang, Jianfeng Liu
Publicado 2021

TRPV6 is a potential regulator of bone resorption in bone loss induced by estrogen deficiency

por Jun Ma, Jiajia Lu, Zhibin Zhou, Nan Lu, Jia He, Lei Zhu, Tianwen Ye
Publicado 2021

The long non-coding RNA CDK6-AS1 overexpression impacts on acute myeloid leukemia differentiation and mitochondrial dynamics

por Elena Porcù, Maddalena Benetton, Valeria Bisio, Ambra Da Ros, Claudia Tregnago, Giulia Borella, Carlo Zanon, Matteo Bordi, Giuseppe Germano, Sabrina Manni, Silvia Campello, Dinesh S. Rao, Franco Locatelli, Martina Pigazzi
Publicado 2021

Microglial transcription profiles in mouse and human are driven by APOE4 and sex

por V. Alexandra Moser, Michael J. Workman, Samantha J. Hurwitz, Rachel M. Lipman, Christian J. Pike, Clive N. Svendsen
Publicado 2021

The role of protease-activated receptor 1 signaling in CD8 T cell effector functions

por Hui Chen, Mindy Smith, Jasmin Herz, Tong Li, Rebecca Hasley, Cecile Le Saout, Ziang Zhu, Jie Cheng, Andres Gronda, José A. Martina, Pablo M. Irusta, Tatiana Karpova, Dorian B. McGavern, Marta Catalfamo
Publicado 2021

Fumarase affects the deoxyribonucleic acid damage response by protecting the mitochondrial desulfurase Nfs1p from modification and inactivation

por Joyce Yip, Suqing Wang, Jasper Tan, Teck Kwang Lim, Qingsong Lin, Zhang Yu, Ofri Karmon, Ophry Pines, Norbert Lehming
Publicado 2021

Patología molecular: Aplicaciones de la biología molecular en anatomía patológica

por I Wistuba O,Ignacio
Publicado 2001

Ética Médica y Medicina Molecular: dos nuevas Secciones en la Revista Médica de Chile

Publicado 1999

La inmunología clínica actual: una perspectiva genética y molecular

por Carrión A,Flavio, E Figueroa,Fernando, Rodríguez G,Cristián
Publicado 2000

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

por Giulio Morozzi, Julian Rothen, Gauthier Toussaint, Katrina De Lange, Katrin Westritschnig, Arno Doelemeyer, Vanessa Pitiot Ueberschlag, Peter Kahle, Christian Lambert, Michael Obrecht, Nicolau Beckmann, Veronique Ritter, Moh Panesar, Daniela Stauffer, Isabelle Garnier, Matthias Mueller, Danilo Guerini, Caroline Gubser Keller, Judith Knehr, Guglielmo Roma, Michael Bidinosti, Sophie Brachat, Frederic Morvan, Mara Fornaro
Publicado 2021

Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

por Karen Rosier, Molly T. McDevitt, Joél Smet, Brendan J. Floyd, Maxime Verschoore, Maria J. Marcaida, Craig A. Bingman, Irma Lemmens, Matteo Dal Peraro, Jan Tavernier, Benjamin F. Cravatt, Natalia V. Gounko, Katlijn Vints, Yenthe Monnens, Kritika Bhalla, Laetitia Aerts, Edrees H. Rashan, Arnaud V. Vanlander, Rudy Van Coster, Luc Régal, David J. Pagliarini, John W.M. Creemers
Publicado 2021

Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel

por Ruiqi Cai, Jingfeng Tang, Xing-Zhen Chen
Publicado 2021

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

por Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
Publicado 2021

Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

por Daryl M. Okamura, Chris M. Brewer, Paul Wakenight, Nadia Bahrami, Kristina Bernardi, Amy Tran, Jill Olson, Xiaogang Shi, Szu-Ying Yeh, Adrian Piliponsky, Sarah J. Collins, Elizabeth D. Nguyen, Andrew E. Timms, James W. MacDonald, Theo K. Bammler, Branden R. Nelson, Kathleen J. Millen, David R. Beier, Mark W. Majesky
Publicado 2021

Stabilin receptors clear LPS and control systemic inflammation

por Fatima Cabral, Mustafa Al-Rahem, John Skaggs, Thushara A. Thomas, Naresh Kumar, Qian Wu, Paolo Fadda, Lianbo Yu, John M. Robinson, Jonghan Kim, Ekta Pandey, Xinghui Sun, Wael N. Jarjour, Murugesan V.S. Rajaram, Edward N. Harris, Latha P. Ganesan
Publicado 2021

MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

por Rebecca Caeser, Christopher Hulton, Emily Costa, Vidushi Durani, Megan Little, Xiaoping Chen, Sam E. Tischfield, Marina Asher, Faruk Erdem Kombak, Shweta S. Chavan, Nisargbhai S. Shah, Metamia Ciampricotti, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen
Publicado 2021

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes

por Jalal M. Kazan, Guillaume Desrochers, Claire E. Martin, Hyeonju Jeong, Dmitri Kharitidi, Pirjo M. Apaja, Ariel Roldan, Nicole St. Denis, Anne-Claude Gingras, Gergely L. Lukacs, Arnim Pause
Publicado 2021