IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer

by Claudia Tulotta, Diane V. Lefley, Charlotte K. Moore, Ana E. Amariutei, Amy R. Spicer-Hadlington, Lewis A. Quayle, Russell O. Hughes, Khawla Ahmed, Victoria Cookson, Catherine A. Evans, Jayakumar Vadakekolathu, Paul Heath, Sheila Francis, Emmanuel Pinteaux, A. Graham Pockley, Penelope D. Ottewell
Published 2021

Molecular stratification of early breast cancer identifies drug targets to drive stratified medicine

by Jane Bayani, Cindy Q. Yao, Mary Anne Quintayo, Fu Yan, Syed Haider, Alister D’Costa, Cassandra L. Brookes, Cornelis J. H. van de Velde, Annette Hasenburg, Dirk G. Kieback, Christos Markopoulos, Luc Dirix, Caroline Seynaeve, Daniel Rea, Paul C. Boutros, John M. S. Bartlett
Published 2017

Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma

by Raul Caso, James G. Connolly, Jian Zhou, Kay See Tan, James J. Choi, Gregory D. Jones, Brooke Mastrogiacomo, Francisco Sanchez-Vega, Bastien Nguyen, Gaetano Rocco, Daniela Molena, Smita Sihag, Prasad S. Adusumilli, Matthew J. Bott, David R. Jones
Published 2021

PERK mediates resistance to BRAF inhibition in melanoma with impaired PTEN

by Yifei Qin, Qiang Zuo, Lei Huang, Liping Huang, Glenn Merlino, Yanlin Yu
Published 2021

Comparative survival analysis of multiparametric tests—when molecular tests disagree—A TEAM Pathology study

by John M. S. Bartlett, Jane Bayani, Elizabeth Kornaga, Keying Xu, Greg R. Pond, Tammy Piper, Elizabeth Mallon, Cindy Q. Yao, Paul C. Boutros, Annette Hasenburg, J. A. Dunn, Christos Markopoulos, Luc Dirix, Caroline Seynaeve, Cornelis J. H. van de Velde, Robert C. Stein, Daniel Rea
Published 2021

Signaling of MK2 sustains robust AP1 activity for triple negative breast cancer tumorigenesis through direct phosphorylation of JAB1

by Haoming Chen, Ravi Padia, Tao Li, Yue Li, Bin Li, Lingtao Jin, Shuang Huang
Published 2021

Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates

by Daniel Y. Joh, Jacob T. Heggestad, Shengwei Zhang, Grace R. Anderson, Jayanta Bhattacharyya, Suzanne E. Wardell, Simone A. Wall, Amy B. Cheng, Faris Albarghouthi, Jason Liu, Sachi Oshima, Angus M. Hucknall, Terry Hyslop, Allison H. S. Hall, Kris C. Wood, E. Shelley Hwang, Kyle C. Strickland, Qingshan Wei, Ashutosh Chilkoti
Published 2021

Risk of hematologic malignancies after breast ductal carcinoma in situ treatment with ionizing radiation

by Kang Wang, Zhuyue Li, Xingxing Chen, Jianjun Zhang, Yongfu Xiong, Guochao Zhong, Yang Shi, Qing Li, Xiang Zhang, Hongyuan Li, Tingxiu Xiang, Theodoros Foukakis, Tomas Radivoyevitch, Guosheng Ren
Published 2021

Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR205 and ErbB

by Arumugam Nagalingam, Sumit Siddharth, Sheetal Parida, Nethaji Muniraj, Dimiter Avtanski, Panjamurthy Kuppusamy, Justin Elsey, Jack L. Arbiser, Balázs Győrffy, Dipali Sharma
Published 2021

Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer

by Della Makower, Juan Lin, Xiaonan Xue, Joseph A. Sparano
Published 2021

Co-dependency for MET and FGFR1 in basal triple-negative breast cancers

by Vanessa Y. C. Sung, Jennifer F. Knight, Radia M. Johnson, Yaakov E. Stern, Sadiq M. Saleh, Paul Savage, Anie Monast, Dongmei Zuo, Stéphanie Duhamel, Morag Park
Published 2021

De-escalation of radiation therapy in patients with stage I, node-negative, HER2-positive breast cancer

by Jose G. Bazan, Sachin R. Jhawar, Daniel Stover, Ko Un Park, Sasha Beyer, Erin Healy, Julia R. White
Published 2021

Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium

by Fei Su, Alexes C. Daquinag, Songyeon Ahn, Achinto Saha, Yulin Dai, Zhongming Zhao, John DiGiovanni, Mikhail G. Kolonin
Published 2021

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia

by Charlotte E. J. Downes, Barbara J. McClure, John B. Bruning, Elyse Page, James Breen, Jacqueline Rehn, David T. Yeung, Deborah L. White
Published 2021

Retraction Note: Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy

by V. La, R. Fujikawa, D. M. Janzen, M. Nunez, L. Bainvoll, L. Hwang, K. Faull, G. Lawson, S. Memarzadeh
Published 2021

Crown-like structures in breast adipose tissue of breast cancer patients: associations with CD68 expression, obesity, metabolic factors and prognosis

by Martin C. Chang, Zohreh Eslami, Marguerite Ennis, Pamela J. Goodwin
Published 2021

TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study

by A. J. M. Meijer, F. A. Diepstraten, T. Langer, L. Broer, I. K. Domingo, E. Clemens, A. G. Uitterlinden, A. C. H. de Vries, M. van Grotel, W. P. Vermeij, R. A. Ozinga, H. Binder, J. Byrne, E. van Dulmen-den Broeder, M. L. Garrè, D. Grabow, P. Kaatsch, M. Kaiser, L. Kenborg, J. F. Winther, C. Rechnitzer, H. Hasle, T. Kepak, K. Kepakova, W. J. E. Tissing, A. L. F. van der Kooi, L. C. M. Kremer, J. Kruseova, S. M. F. Pluijm, C. E. Kuehni, H. J. H. van der Pal, R. Parfitt, C. Spix, A. Tillmanns, D. Deuster, P. Matulat, G. Calaminus, A. E. Hoetink, S. Elsner, J. Gebauer, R. Haupt, H. Lackner, C. Blattmann, S. J. C. M. M. Neggers, S. R. Rassekh, G. E. B. Wright, B. Brooks, A. P. Nagtegaal, B. I. Drögemöller, C. J. D. Ross, A. P. Bhavsar, A. G. am Zehnhoff-Dinnesen, B. C. Carleton, O. Zolk, M. M. van den Heuvel-Eibrink, the PanCareLIFE Consortium, and the CPNDS Consortium
Published 2021

Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer

by Ikuko Takeda Nakamura, Shinji Kohsaka, Masachika Ikegami, Hiroshi Ikeuchi, Toshihide Ueno, Kunhua Li, Tyler S. Beyett, Takafumi Koyama, Toshio Shimizu, Noboru Yamamoto, Fumiyuki Takahashi, Kazuhisa Takahashi, Michael J. Eck, Hiroyuki Mano
Published 2021

Combined FGFR and Akt pathway inhibition abrogates growth of FGFR1 overexpressing EGFR-TKI-resistant NSCLC cells

by Mikkel G. Terp, Kirstine Jacobsen, Miguel Angel Molina, Niki Karachaliou, Hans C. Beck, Jordi Bertran-Alamillo, Ana Giménez-Capitán, Andrés F. Cardona, Rafael Rosell, Henrik J. Ditzel
Published 2021

Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the ZNF423 and CTSO genes

by Duan Liu, Ming-Fen Ho, Daniel J. Schaid, Steven E. Scherer, Krishna Kalari, Mohan Liu, Joanna Biernacka, Vivien Yee, Jared Evans, Erin Carlson, Matthew P. Goetz, Michiaki Kubo, D. Lawrence Wickerham, Liewei Wang, James N. Ingle, Richard M. Weinshilboum
Published 2017