Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer

por Guru Sonpavde, Na Li, Zheng Zhu, Fan Cheng, Shaoming Zhu, A-Hong Ma, Elio Adib, Ting Rao, Kaiyuan Ni, Veera Chandra Sekhar Reddy Chittepu, Rao Prabhala, Juan Garisto Risco, David Kwiatkowski, Kent Mouw, Chong-xian Pan
Publicado 2021

Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity

por Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Joshua S. Samudre, Morgan E. Collins, Alifiani B. Hartono, Sean B. Lee, Frank Lau, Melody Baddoo, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Publicado 2021

KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF-mutant melanoma

por Antoni Ribas, Inge Marie Svane, Paolo Antonio Ascierto, Victoria Atkinson, Razi Ghori, Anna Maria Di Giacomo, Georgina V Long, Henrik Schmidt, Jacob Schachter, Eduard Gasal, Paola Queirolo, Michal Lotem, Michele Del Vecchio, Pier Francesco Ferrucci, Rosalie Stephens, Mahmoud Abu-Amna, Scott J Diede, Elizabeth S Croydon
Publicado 2020

Overexpression of CD200 is a stem cell-specific mechanism of immune evasion in AML

por R Eric Davis, Marina Konopleva, Natalia Baran, Gheath Al-Atrash, Naval Daver, Shelley Herbrich, Tianyu Cai, Connie Weng, Marisa J L Aitken, Sean M Post, Jared Henderson, Chunhua Shi, Guillame Richard-Carpentier, Guy Sauvageau, Keith Baggerly, Dongxing Zha, Ondrej Havranek
Publicado 2021

Correction to: ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma

por Weipu Mao, Keyi Wang, Bin Xu, Hui Zhang, Si Sun, Qiang Hu, Lei Zhang, Chunhui Liu, Shuqiu Chen, Jianping Wu, Ming Chen, Wei Li, Bo Peng
Publicado 2021

Correction to: Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma

por Aibin Liu, Jinrong Zhu, Geyan Wu, Lixue Cao, Zhanyao Tan, Shuxia Zhang, Lili Jiang, Jueheng Wu, Mengfeng Li, Libing Song, Jun Li
Publicado 2021

Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

por Carlos Fernández de Larrea, Robert Kyle, Laura Rosiñol, Bruno Paiva, Monika Engelhardt, Saad Usmani, Jo Caers, Wilson Gonsalves, Fredrik Schjesvold, Giampaolo Merlini, Suzanne Lentzch, Enrique Ocio, Laurent Garderet, Philippe Moreau, Pieter Sonneveld, Ashraf Badros, Gösta Gahrton, Hartmut Goldschmidt, Sascha Tuchman, Hermann Einsele, Brian Durie, Baldeep Wirk, Pellegrino Musto, Patrick Hayden, Martin Kaiser, Jesús San Miguel, Joan Bladé, S. Vincent Rajkumar, Maria Victoria Mateos
Publicado 2021

Phase II, single-arm trial of preoperative short-course radiotherapy followed by chemotherapy and camrelizumab in locally advanced rectal cancer

por Jun Fan, Tao Zhang, Xin Li, Lan Zhang, Zheng Wang, Tao Liu, Gang Li, Peng Zhang, Chi Ma, Ming Cai, Gang Wu, Zhenyu Lin, Kailin Cai, Xiu Nie, Junli Liu, Hongli Liu, Weikang Zhang, Jingbo Gao, Chuanqing Wu, Linfang Wang, Zhiguo Hou, Kunyu Yang, Kaixiong Tao
Publicado 2021

Differentiation therapy for myeloid malignancies: beyond cytotoxicity

por Ryan J. Stubbins, Aly Karsan
Publicado 2021

Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study

por Saemundur Rognvaldsson, Elias Eythorsson, Sigrun Thorsteinsdottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni A. Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdóttir, Isleifur Olafsson, Hrafnhildur L. Runolfsdottir, Dadi Helgason, Arna R. Emilsdottir, Arnar S. Agustsson, Aron H. Bjornsson, Gudrun Kristjansdottir, Asdis Rosa Thordardottir, Olafur Skuli Indridason, Asbjorn Jonsson, Gauti Kjartan Gislason, Andri Olafsson, Hlif Steingrimsdottir, Petros Kampanis, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, Runolfur Palsson, Thorvarður Jon Love, Sigurdur Yngvi Kristinsson
Publicado 2021

MPL S505C enhances driver mutations at W515 in essential thrombocythemia

por Leila N. Varghese, Gonzalo Carreño-Tarragona, Gabriel Levy, Xabier Gutiérrez-López de Ocáriz, Inmaculada Rapado, Joaquín Martínez-López, Rosa Ayala, Stefan N. Constantinescu
Publicado 2021

Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT

por Hee Jeong Cho, Sung-Hoon Jung, Jae-Cheol Jo, Yoo Jin Lee, Sang Eun Yoon, Sung-Soo Park, Do Young Kim, Ho-Jin Shin, Yeung-Chul Mun, Jun Ho Yi, Hyo Jung Kim, Da Jung Kim, Ho Sup Lee, Sung Hwa Bae, Chae Moon Hong, Shin Young Jeong, Jung-Joon Min, Sang Kyun Sohn, Chang-Ki Min, Kihyun Kim, Je-Jung Lee, Joon Ho Moon, The Korean Multiple Myeloma Working Party
Publicado 2021

Thrombocytosis in COVID-19 patients without myeloproliferative neoplasms is associated with better prognosis but higher rate of venous thromboembolism

por Marko Lucijanic, Ivan Krecak, Ena Soric, Martina Sedinic, Anica Sabljic, Lovorka Derek, Ozren Jaksic, Rajko Kusec
Publicado 2021

Letter to the editor from Pant et al

por Aung Naing, Shubham Pant, Justin T Moyers
Publicado 2021

Correction to: PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance

por Chenchen Feng, Yuqing Li, Kunping Li, Yinfeng Lyu, Wenhui Zhu, Haowen Jiang, Hui Wen
Publicado 2021

Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes

por Gabriela Palma, Faisal Khurshid, Kevin Lu, Brian Woodward, Hatim Husain
Publicado 2021

Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition

por Niamh Coleman, Vivek Subbiah, Shubham Pant, Keyur Patel, Sinchita Roy-Chowdhuri, Sireesha Yedururi, Amber Johnson, Timothy A. Yap, Jordi Rodon, Kenna Shaw, Funda Meric-Bernstam
Publicado 2021

Correction to: LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells

por Weidong Li, Xuesong Dong, Changjun He, Gang Tan, Ziyi Li, Bo Zhai, Jing Feng, Xian Jiang, Chang Liu, Hongchi Jiang, Xueying Sun
Publicado 2021

CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression

por Qing Liao, Yun Ren, Yuyi Yang, Xiaohui Zhu, Yunfei Zhi, Yujie Zhang, Yi Chen, Yanqing Ding, Liang Zhao
Publicado 2021

Acupuncture versus cognitive behavioral therapy for pain among cancer survivors with insomnia: an exploratory analysis of a randomized clinical trial

por Mingxiao Yang, Kevin T. Liou, Sheila N. Garland, Ting Bao, Tony K. W. Hung, Susan Q. Li, Yuelin Li, Jun J. Mao
Publicado 2021