A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer

por Natalia J. Gurule, Caroline E. McCoach, Trista K. Hinz, Daniel T. Merrick, Adriaan Van Bokhoven, Jihye Kim, Tejas Patil, Jacob Calhoun, Raphael A. Nemenoff, Aik Choon Tan, Robert C. Doebele, Lynn E. Heasley
Publicado 2021

NRG Oncology/NSABP B-47 menstrual history study: impact of adjuvant chemotherapy with and without trastuzumab

por Patricia A. Ganz, Reena S. Cecchini, Louis Fehrenbacher, Charles E. Geyer, Priya Rastogi, John P. Crown, Michael P. Thirlwell, David M. Ellison, Jean-Francois Boileau, Patrick J. Flynn, Jong-Hyeon Jeong, Eleftherios P. Mamounas, Norman Wolmark
Publicado 2021

Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

por Oana A. Zeleznik, Raji Balasubramanian, Yibai Zhao, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Shelley S. Tworoger, A. Heather Eliassen
Publicado 2021

Will polygenic risk scores for cancer ever be clinically useful?

por Amit Sud, Clare Turnbull, Richard Houlston
Publicado 2021

Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia

por Mayumi Sugita, David C. Wilkes, Rohan Bareja, Kenneth W. Eng, Sarah Nataraj, Reyna A. Jimenez-Flores, LunBiao Yan, Jeanne Pauline De Leon, Jaclyn A. Croyle, Justin Kaner, Swathi Merugu, Sahil Sharma, Theresa Y. MacDonald, Zohal Noorzad, Palak Panchal, Danielle Pancirer, Shuhua Cheng, Jenny Z. Xiang, Luke Olson, Koen Van Besien, David S. Rickman, Susan Mathew, Wayne Tam, Mark A. Rubin, Himisha Beltran, Andrea Sboner, Duane C. Hassane, Gabriela Chiosis, Olivier Elemento, Gail J. Roboz, Juan Miguel Mosquera, Monica L. Guzman
Publicado 2021

Next-generation sequencing revealed recurrent ZFPM1 mutations in encapsulated papillary carcinoma of the breast

por Xuguang Liu, Xin Huang, Yan Bai, Zhiwen Zhang, Tiefeng Jin, Huanwen Wu, Zhiyong Liang
Publicado 2021

How I faced my prostate cancer: a molecular biologist’s perspective

por Monica Zuradelli, Massimo Lazzeri, Egesta Lopci, Paolo Andrea Zucali, Luca Balzarini, Giorgio Guazzoni, Piergiuseppe Colombo, Marta Scorsetti, Ciro Franzese, Rosanna Asselta, Giulia Soldà, Stefano Duga
Publicado 2021

Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer

por Adrián Sánchez-Fdez, María Florencia Re-Louhau, Pablo Rodríguez-Núñez, Dolores Ludeña, Sofía Matilla-Almazán, Atanasio Pandiella, Azucena Esparís-Ogando
Publicado 2021

Genetic epidemiology of BRCA1- and BRCA2-associated cancer across Latin America

por Josef S. Herzog, Yanin Chavarri-Guerra, Danielle Castillo, Julio Abugattas, Cynthia Villarreal-Garza, Sharon Sand, Jessica Clague-Dehart, Rosa M. Alvarez-Gómez, Talia Wegman-Ostrosky, Alejandro Mohar, Pamela Mora, Azucena Del Toro-Valero, Adrian Daneri-Navarro, Yenni Rodriguez, Marcia Cruz-Correa, Patricia Ashton-Prolla, Bárbara Alemar, Rosa Mejia, Lenny Gallardo, Robin Shaw, Kai Yang, Aleck Cervantes, Kevin Tsang, Bita Nehoray, Hugo Barrera Saldana, Susan Neuhausen, Jeffrey N. Weitzel
Publicado 2021

Trigger point injection for post-mastectomy pain: a simple intervention with high rate of long-term relief

por Amal L. Khoury, Holly Keane, Flora Varghese, Ava Hosseini, Rita Mukhtar, Suzanne E. Eder, Philip R. Weinstein, Laura J. Esserman
Publicado 2021

High CYP27A1 expression is a biomarker of favorable prognosis in premenopausal patients with estrogen receptor positive primary breast cancer

por Maria Inasu, Pär-Ola Bendahl, Mårten Fernö, Per Malmström, Signe Borgquist, Siker Kimbung
Publicado 2021

Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

por Francesco Schettini, Nuria Chic, Fara Brasó-Maristany, Laia Paré, Tomás Pascual, Benedetta Conte, Olga Martínez-Sáez, Barbara Adamo, Maria Vidal, Esther Barnadas, Aranzazu Fernández-Martinez, Blanca González-Farre, Esther Sanfeliu, Juan Miguel Cejalvo, Giuseppe Perrone, Giovanna Sabarese, Francesca Zalfa, Vicente Peg, Roberta Fasani, Patricia Villagrasa, Joaquín Gavilá, Carlos H. Barrios, Ana Lluch, Miguel Martín, Mariavittoria Locci, Sabino De Placido, Aleix Prat
Publicado 2021

Nivolumab in combination with cabozantinib for metastatic triple-negative breast cancer: a phase II and biomarker study

por Romualdo Barroso-Sousa, Tanya E. Keenan, Tianyu Li, Nabihah Tayob, Lorenzo Trippa, Ricardo G. Pastorello, Edward T. Richardson III, Deborah Dillon, Zohreh Amoozgar, Beth Overmoyer, Stuart J. Schnitt, Eric P. Winer, Elizabeth A. Mittendorf, Eliezer Van Allen, Dan G. Duda, Sara M. Tolaney
Publicado 2021

Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer

por Ying L. Liu, Cecilie Liv Bager, Nicholas Willumsen, Divya Ramchandani, Naomi Kornhauser, Lu Ling, Marta Cobham, Eleni Andreopoulou, Tessa Cigler, Anne Moore, Dayle LaPolla, Veronica Fitzpatrick, Maureen Ward, J. David Warren, Claudia Fischbach, Vivek Mittal, Linda T. Vahdat
Publicado 2021

Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer

por Jingyi Wang, Ge Ma, Han Ge, Xu Han, Xinrui Mao, Xinyang Wang, Jordee Selvamanee Veeramootoo, Tiansong Xia, Xiaoan Liu, Shui Wang
Publicado 2021

FDG positron emission tomography imaging and ctDNA detection as an early dynamic biomarker of everolimus efficacy in advanced luminal breast cancer

por Andrea Gombos, David Venet, Lieveke Ameye, Peter Vuylsteke, Patrick Neven, Vincent Richard, Francois P. Duhoux, Jean-Francois Laes, Françoise Rothe, Christos Sotiriou, Marianne Paesmans, Ahmad Awada, Thomas Guiot, Patrick Flamen, Martine Piccart-Gebhart, Michail Ignatiadis, Géraldine Gebhart
Publicado 2021

Genetic mutation and biological pathway prediction based on whole slide images in breast carcinoma using deep learning

por Hui Qu, Mu Zhou, Zhennan Yan, He Wang, Vinod K. Rustgi, Shaoting Zhang, Olivier Gevaert, Dimitris N. Metaxas
Publicado 2021

MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

por Sanne Løkkegaard, Daniel Elias, Carla L. Alves, Martin V. Bennetzen, Anne-Vibeke Lænkholm, Martin Bak, Morten F. Gjerstorff, Lene E. Johansen, Henriette Vever, Christina Bjerre, Tove Kirkegaard, Bo Nordenskjöld, Tommy Fornander, Olle Stål, Linda S. Lindström, Laura J. Esserman, Anne E. Lykkesfeldt, Jens S. Andersen, Rikke Leth-Larsen, Henrik J. Ditzel
Publicado 2021

A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases

por Natalie S. Joe, Christine Hodgdon, Lianne Kraemer, Kristin J. Redmond, Vered Stearns, Daniele M. Gilkes
Publicado 2021

A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures

por Miklos Diossy, Zsofia Sztupinszki, Judit Borcsok, Marcin Krzystanek, Viktoria Tisza, Sandor Spisak, Orsolya Rusz, Jozsef Timar, István Csabai, Janos Fillinger, Judit Moldvay, Anders Gorm Pedersen, David Szuts, Zoltan Szallasi
Publicado 2021