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  1. 11301
    The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis
    “... in tumor cells depend on the formation of a HSF1–PARP13–PARP1 complex....”
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  2. 11302
    An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy
    “...-tumor effects in HER2+ cancer and is required for the response to Trastuzumab....”
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  3. 11303
    A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
    “... /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activity...”
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  4. 11304
    Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
    “...Stromal cells play various roles in tumor establishment and metastasis. Here the authors, using...”
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  5. 11305
    iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
    “... solid tumours. Here, the authors show that loading the tumor penetrating cyclic peptide iRGD on the cell...”
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  6. 11306
    High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
    “...It is unclear how intra-tumoral heterogeneity contributes to metastasis. Here the authors study...”
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  7. 11307
    Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics
    “... oxide nanocomposites (eMIONs) with excellent magnetic-heat capability and catalysis-triggered tumor...”
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  8. 11308
    A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy
    “...Tumor hypoxia is a major limitation in radiotherapy, and strategies to address this often fail due...”
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  9. 11309
    Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
    “... reprogram the tumor immune microenvironment and improve responses to anti-PD-1 therapy....”
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  10. 11310
    Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
    “... exposure, with improved tumor control....”
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  11. 11311
    Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
    “...The tumor suppressor p53 is a master regulator of cellular stress response pathways, including cell...”
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  12. 11312
    Common germline-somatic variant interactions in advanced urothelial cancer
    “... the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced...”
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  13. 11313
    NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
    “... and that NEK2 targeting restores anti-tumor immune responses in preclinical models of pancreatic cancer....”
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  14. 11314
    Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
    “... agonists suppress tumor growth of subcutaneous xenografts models inducing early apoptosis of endothelial...”
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  15. 11315
    Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
    “...Cancer stem cells (CSCs) have key roles in tumor initiation and metastasis. Here, the authors show...”
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  16. 11316
    Mechanically interlocked functionalization of monoclonal antibodies
    “... stability, create functionalized antibodies by click chemistry and use them for in vivo tumor imaging....”
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  17. 11317
    Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment
    “...Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential...”
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  18. 11318
    U1 snRNP regulates cancer cell migration and invasion in vitro
    “... and 3’-end processing. Here the authors show a tumor suppressor-like function of U1 snRNP using in vitro...”
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  19. 11319
    LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
    “...miR-205 is known to have context-dependent tumor suppressive or oncogenic roles. Here, the authors...”
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  20. 11320
    Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity
    “... and agonistic strength to these outcomes, and engineer a 4-1BB antibody with potent anti-tumor effect...”
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