α-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt

por Nishith M Shrimali, Sakshi Agarwal, Simrandeep Kaur, Sulagna Bhattacharya, Sankar Bhattacharyya, Josef T Prchal, Prasenjit Guchhait
Publicado 2021

AGTR1 Inhibits the Progression of Lung Adenocarcinoma

por Xiong L, Wei Y, Zhou X, Dai P, Cai Y, Zhou X, Xu M, Zhao J, Tang H
Publicado 2021

Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway

por Yunfeng Yuan, Xue He, Xiang Li, Yan Liu, Yueliang Tang, Huiming Deng, Xinyuan Shi
Publicado 2021

The MIRNA mir-582-3p suppresses ovarian cancer progression by targeting AKT/MTOR signaling via lncRNA TUG1

por Tianyu Dai, Junhui Liang, Wei Liu, Yonghui Zou, Feifei Niu, Mengqing Li, Haomeng Zhang, Changzhong Li, Mingjun Fan, Guoying Cui
Publicado 2021

Pongol Methyl Ether Inhibits Akt and Suppresses Cancer Stem Cell Phenotypes in Lung Cancer Cells

por Arnon Silapech, Satapat Racha, Nithikoon Aksorn, Pennapa Lafauy, Sucharat Tungsukruthai, Chanida Vinayanuwattikun, Boonchoo Sritularak, Pithi Chanvorachote
Publicado 2021

Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach

por Torki A. Zughaibi, Mohd Suhail, Mohammad Tarique, Shams Tabrez
Publicado 2021

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

por Erskine Chu, Richelle Mychasiuk, Margaret L. Hibbs, Bridgette D. Semple
Publicado 2021

The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinosito...

por Hongwei Zheng, Wenlun Wang, Shichang Li, Lin Han
Publicado 2021

Perifosine, a Bioavailable Alkylphospholipid Akt Inhibitor, Exhibits Antitumor Activity in Murine Models of Cancer Brain Metastasis Through Favorable Tumor Exposure

por Keisuke Taniguchi, Tomo Suzuki, Tomomi Okamura, Akinobu Kurita, Gou Nohara, Satoru Ishii, Shoichi Kado, Akimitsu Takagi, Momomi Tsugane, Yoshiyuki Shishido
Publicado 2021

miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2

por Yuan Haibin, Liu Fengli, Ma Tongsheng, Zeng Zhandong, Zhang Ning
Publicado 2021

Silencing of miR-20b-5p Exerts Inhibitory Effect on Diabetic Retinopathy via Inactivation of THBS1 Gene Induced VEGF/Akt/PI3K Pathway

por Ma Y, Dong C, Chen X, Zhu R, Wang J
Publicado 2021

Ursolic Acid Accelerates Paclitaxel-Induced Cell Death in Esophageal Cancer Cells by Suppressing Akt/FOXM1 Signaling Cascade

por Ruo Yu Meng, Hua Jin, Thi Van Nguyen, Ok-Hee Chai, Byung-Hyun Park, Soo Mi Kim
Publicado 2021

Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT

por Mahamat Babagana, Lorin R. Brown, Hannah Z. Slabodkin, Julia V. Kichina, Eugene S. Kandel
Publicado 2021

Oleanolic acid induces apoptosis and autophagy via the PI3K/AKT/mTOR pathway in AGS human gastric cancer cells

por Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Soo-Hyun Jung, Bum Seok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Publicado 2021

Hydroquinone 5-<i>O</i>-Cinnamoyl Ester of Renieramycin M Suppresses Lung Cancer Stem Cells by Targeting Akt and Destabilizes c-Myc

por Nattamon Hongwiangchan, Nicharat Sriratanasak, Duangdao Wichadakul, Nithikoon Aksorn, Supakarn Chamni, Pithi Chanvorachote
Publicado 2021

Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway

por Xinyi Cheng, Zhanyou Cao, Junrong Luo, Ruiming Hu, Huabin Cao, Xiaoquan Guo, Chenghong Xing, Fan Yang, Yu Zhuang, Guoliang Hu
Publicado 2022

Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway

por Yi Cheng, Guiying Wang, Guiying Wang, Lianmei Zhao, Suli Dai, Jing Han, Xuhua Hu, Chaoxi Zhou, Feifei Wang, Hongqing Ma, Baokun Li, Zesong Meng
Publicado 2021

DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis

por Shouliang Xiong, Yong Zhao, Tiantong Xu
Publicado 2021

BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy

por Rameswari Chilamakuri, Danielle C. Rouse, Yang Yu, Abbas S. Kabir, Aaron Muth, Jianhua Yang, Jeffery M. Lipton, Saurabh Agarwal
Publicado 2022

Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer

por Suchitra Maheswari Ajjarapu, Apoorv Tiwari, Gohar Taj, Dev Bukhsh Singh, Sakshi Singh, Sundip Kumar
Publicado 2021