Epidermal Growth Factor Protects Against High Glucose-Induced Podocyte Injury Possibly via Modulation of Autophagy and PI3K/AKT/mTOR Signaling Pathway Through DNA Methylation

por Sun Y, Deng M, Ke X, Lei X, Ju H, Liu Z, Bai X
Publicado 2021

miR-7a Targets Insulin Receptor Substrate-2 Gene and Suppresses Viability and Invasion of Cells in Diabetic Retinopathy Mice via PI3K-Akt-VEGF Pathway

por Ji Z, Luo J, Su T, Chen C, Su Y
Publicado 2021

Protective effect of sargahydroquinoic acid against Aβ25–35-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system

por Jeong-Hyun Yoon, Kumju Youn, Mira Jun
Publicado 2021

Molecular Studies on the Nephroprotective Potential of <i>Celastrus paniculatus</i> against Lead-Acetate-Induced Nephrotoxicity in Experimental Rats: Role of the PI3K/AKT Signaling...

por Karunakaran Balaji, Jagadish Vijayakumar, Ponnusamy Kasirajan Sankaran, Sivanesan Senthilkumar, Rajagopalan Vijayaraghavan, Jayaraman Selvaraj, Maria Francis Yuvaraj
Publicado 2021

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

por Liang-Chao Wang, Liang-Chao Wang, Wei-Yen Wei, Pei-Chuan Ho, Pei-Yi Wu, Yuan-Ping Chu, Kuen-Jer Tsai, Kuen-Jer Tsai, Kuen-Jer Tsai
Publicado 2021

The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer

por Alba Orea-Soufi, Sonia Castillo-Lluva, Nélida Salvador-Tormo, Paola Martín-Cabrera, Silvia Recuero, Estíbaliz Gabicagogeascoa, Manuel Moreno-Valladares, Marina Mendiburu-Eliçabe, Adrián Blanco-Gómez, José Miguel Ramos-Pittol, Elena García-Taboada, Alberto Ocaña, Francisco J. Cimas, Ander Matheu, Isabel Álvarez-López, Guillermo Velasco, Mar Lorente
Publicado 2021

Circ_0016760 accelerates non‐small‐cell lung cancer progression through miR‐646/AKT3 signaling in vivo and in vitro

por Shan Chen, Long Zhou, Ruizhi Ran, Jinqi Huang, Yong Zheng, Maohui Xing, Yanli Cai
Publicado 2021

Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinas...

por Zhonghai Xie, Hongwei Li, Jin Zang
Publicado 2021

Opportunities for metastatic triple negative breast cancer therapy

por Inna P. Ganshina, Olga O. Gordeeva, Mariam S. Manukyan
Publicado 2021

Cancer-Associated Fibroblasts Promote the Upregulation of PD-L1 Expression Through Akt Phosphorylation in Colorectal Cancer

por Yang Gao, Zhao Sun, Junjie Gu, Zhe Li, Xiuxiu Xu, Chunling Xue, Xuechun Li, Lin Zhao, Jianfeng Zhou, Chunmei Bai, Qin Han, Robert Chunhua Zhao, Robert Chunhua Zhao
Publicado 2021

The impact of cardiomotor rehabilitation on endothelial function in elderly patients with chronic heart failure

por Juming Chen, Shenhong Gu, Yanling Song, Xinbo Ji, Wangyuan Zeng, Xiaoxi Wang, Yachun Wang, Qingfeng Feng
Publicado 2021

Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/...

por Nour Y.S. Yassin, Sameh F. AbouZid, Asmaa M. El-Kalaawy, Tarek M. Ali, Mazen M. Almehmadi, Osama M. Ahmed
Publicado 2022

The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of <em>Prmt7</em>/<em>Akt3</em> Pathway

por Bingyuan Wang, Mingrui Zhang, Jiankang Guo, Zhiguo Liu, Rong Zhou, Fei Guo, Kui Li, Yulian Mu
Publicado 2021

Combinatorial Regimen of Carbamazepine and Imipramine Exhibits Synergism against Grandmal Epilepsy in Rats: Inhibition of Pro-Inflammatory Cytokines and PI3K/Akt/mTOR Signaling Pat...

por Faheem Hyder Pottoo, Mohammed Salahuddin, Firdos Alam Khan, Marwa Abdullah AL Dhamen, Walaa Jafar Alsaeed, Mohamed S. Gomaa, Chittibabu Vatte, Mohammad N. Alomary
Publicado 2021

Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al

por Chanting He, Xiaoyan Zhao, Yang Lei, Jisheng Nie, Xiaoting Lu, Jing Song, Linping Wang, Huan Li, Fangqu Liu, Yidan Zhang, Qiao Niu
Publicado 2021

1-Formyl-<i>β</i>-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes

por Chongyang Wang, Ting Wang, Jiangkun Dai, Zhiyuan An, Ruochen Hu, Liuyuan Duan, Hui Chen, Xiangwei Wang, Zhili Chu, Haijin Liu, Juan Wang, Na Li, Zengqi Yang, Junru Wang
Publicado 2021

Effects of Taohong Siwu Decoction on coagulation function and PI3K/ AKT/mTOR pathway after femoral artery anastomosis in rabbits

por Xin-Jun Xie, Zhuo-Ma Dong-Zhi
Publicado 2021

Integrated Network Pharmacology and Lipidomics to Reveal the Inhibitory Effect of Qingfei Oral Liquid on Excessive Autophagy in RSV-Induced Lung Inflammation

por Lili Lin, Li An, Hui Chen, Lu Feng, Mengjiang Lu, Yuling Liu, Chu Chu, Jinjun Shan, Tong Xie, Xiaorong Wang, Shouchuan Wang
Publicado 2021

Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

por Adina Gerson-Gurwitz, Nathan P. Young, Vikas K. Goel, Boreth Eam, Craig R. Stumpf, Joan Chen, Sarah Fish, Maria Barrera, Eric Sung, Jocelyn Staunton, Gary G. Chiang, Kevin R. Webster, Peggy A. Thompson
Publicado 2021

Upregulation of IRF9 Contributes to Pulmonary Artery Smooth Muscle Cell Proliferation During Pulmonary Arterial Hypertension

por Yong-Jie Chen, Yong-Jie Chen, Yi Li, Xian Guo, Bo Huo, Yue Chen, Yi He, Rui Xiao, Rui Xiao, Xue-Hai Zhu, Xue-Hai Zhu, Ding-Sheng Jiang, Ding-Sheng Jiang, Xiang Wei, Xiang Wei
Publicado 2021