Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models

por Rose M. Langsjoen, Sherry L. Haller, Chad J. Roy, Heather Vinet-Oliphant, Nicholas A. Bergren, Jesse H. Erasmus, Jill A. Livengood, Tim D. Powell, Scott C. Weaver, Shannan L. Rossi
Publicado 2018

Molecular Characterization of Associated Pathogens in Febrile Patients during Inter-Epidemic Periods of Urban Arboviral Diseases in Tapachula Southern Mexico

por Geovana Calvo-Anguiano, José de Jesús Lugo-Trampe, Gustavo Ponce-García, Angel Lugo-Trampe, Laura Elia Martinez-Garza, Marisol Ibarra-Ramirez, Luis Daniel Campos-Acevedo, Sandra Caballero-Sosa, Alan Esteban Juache-Villagrana, Ildefonso Fernández-Salas, Adriana Elizabeth Flores-Suarez, Iram Pablo Rodriguez-Sanchez, Karina del Carmen Trujillo-Murillo
Publicado 2021

Favipiravir Inhibits Mayaro Virus Infection in Mice

por Michèle Bengue, Ai-rada Pintong, Florian Liegeois, Antoine Nougairède, Rodolphe Hamel, Julien Pompon, Xavier de Lamballerie, Pierre Roques, Valérie Choumet, Dorothée Missé
Publicado 2021

Differential Alphavirus Defective RNA Diversity between Intracellular and Extracellular Compartments Is Driven by Subgenomic Recombination Events

por R. M. Langsjoen, A. E. Muruato, S. R. Kunkel, E. Jaworski, A. Routh
Publicado 2020

The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent

por Whitney C. Lane, Matthew D. Dunn, Christina L. Gardner, L. K. Metthew Lam, Alan M. Watson, Amy L. Hartman, Kate D. Ryman, William B. Klimstra
Publicado 2018

Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

por Brent A. Hackett, Mark Dittmar, Elisha Segrist, Nathan Pittenger, Julie To, Trevor Griesman, Beth Gordesky-Gold, David C. Schultz, Sara Cherry
Publicado 2019

Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology

por Jennifer E. Jones, Kristin M. Long, Alan C. Whitmore, Wes Sanders, Lance R. Thurlow, Julia A. Brown, Clayton R. Morrison, Heather Vincent, Kayla M. Peck, Christian Browning, Nathaniel Moorman, Jean K. Lim, Mark T. Heise
Publicado 2017

Increasing the Capping Efficiency of the Sindbis Virus nsP1 Protein Negatively Affects Viral Infection

por Autumn T. LaPointe, Joaquín Moreno-Contreras, Kevin J. Sokoloski
Publicado 2018

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production...

por Xiang Liu, Margit Mutso, Age Utt, Anni Lepland, Lara J. Herrero, Adam Taylor, Jayaram Bettadapura, Penny A. Rudd, Andres Merits, Suresh Mahalingam
Publicado 2018

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

por Jessica L. Smith, Christine L. Pugh, Emily D. Cisney, Sarah L. Keasey, Carolina Guevara, Julia S. Ampuero, Guillermo Comach, Doris Gomez, Margarita Ochoa-Diaz, Robert D. Hontz, Robert G. Ulrich
Publicado 2018

Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly

por Judy J. Wan, Rebecca S. Brown, Margaret Kielian
Publicado 2020

Limited Evidence for Infection of Urban and Peri-urban Nonhuman Primates with Zika and Chikungunya Viruses in Brazil

por Andres Moreira-Soto, Ianei de Oliveira Carneiro, Carlo Fischer, Marie Feldmann, Beate M. Kümmerer, Nama Santos Silva, Uilton Góes Santos, Breno Frederico de Carvalho Dominguez Souza, Fernanda de Azevedo Liborio, Mônica Mafra Valença-Montenegro, Plautino de Oliveira Laroque, Fernanda Rosa da Fontoura, Alberto Vinicius Dantas Oliveira, Christian Drosten, Xavier de Lamballerie, Carlos Roberto Franke, Jan Felix Drexler
Publicado 2018

Enhanced Molecular Surveillance of Chikungunya Virus

por Carlo Fischer, Xavier de Lamballerie, Jan Felix Drexler
Publicado 2019

Production of Noncapped Genomic RNAs Is Critical to Sindbis Virus Disease and Pathogenicity

por Autumn T. LaPointe, V Douglas Landers, Claire E. Westcott, Kevin J. Sokoloski
Publicado 2020

DDX56 Binds to Chikungunya Virus RNA To Control Infection

por Frances Taschuk, Iulia Tapescu, Ryan H. Moy, Sara Cherry
Publicado 2020

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model

por Olga Trofimova, Ksenija Korotkaja, Dace Skrastina, Juris Jansons, Karina Spunde, Maria Isaguliants, Anna Zajakina
Publicado 2021

An <italic toggle="yes">Alphavirus</italic> E2 Membrane-Proximal Domain Promotes Envelope Protein Lateral Interactions and Virus Budding

por Emily A. Byrd, Margaret Kielian
Publicado 2017

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

por Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra
Publicado 2018

A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses

por Lindsey A. Moser, Lisbeth Ramirez-Carvajal, Vinita Puri, Steven J. Pauszek, Krystal Matthews, Kari A. Dilley, Clancy Mullan, Jennifer McGraw, Michael Khayat, Karen Beeri, Anthony Yee, Vivien Dugan, Mark T. Heise, Matthew B. Frieman, Luis L. Rodriguez, Kristen A. Bernard, David E. Wentworth, Timothy B. Stockwell, Reed S. Shabman
Publicado 2016

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice

por Rachy Abraham, Robert L. McPherson, Morgan Dasovich, Mohsen Badiee, Anthony K. L. Leung, Diane E. Griffin
Publicado 2020