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  1. 1141
    Transcatheter aortic valve replacement in patients with bicuspid aortic valve stenosis: national trends and in-hospital outcomes
    “... with AS were excluded from all pivotal trials that led to TAVR approval. We sought, therefore, to examine...”
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  2. 1142
    Profile of palbociclib in the treatment of metastatic breast cancer
    por Ehab M, Elbaz M
    Publicado 2016
    “... CDK4 and CDK6, play a pivotal role in cell cycle progression that makes them potential targets for new...”
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  3. 1143
    Symptomatic stability with aripiprazole once-monthly: efficacy analyses from acute and long-term studies
    por Madera JJ, Such P, Zhao C, Baker RA
    Publicado 2019
    “... in patients with schizophrenia.Methods: Results were analyzed from two pivotal maintenance studies (Studies...”
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  4. 1144
    Mapping of Urinary Schistosomiasis in Anambra State, Nigeria
    “...Background: Mapping the distribution of parasitic diseases in time and space has a pivotal role...”
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  5. 1145
    Role of Hedgehog–Gli1 signaling in the enhanced proliferation and differentiation of MG63 cells enabled by hierarchical micro-/nanotextured topography
    por Lin Y, Huang Y, He J, Chen F, He Y, Zhang W
    Publicado 2017
    “... demonstrates pivotal roles of Hedgehog–Gli1 signaling pathway in mediating the enhanced effect of MNTs...”
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  6. 1146
    Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1
    “.... Altogether, our findings provide insight into the pivotal involvement of FoxM1 in the tumor suppressive...”
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  7. 1147
    Impact of Galectin-Receptor Interactions on Liver Pathology During the Erythrocytic Stage of Plasmodium berghei Malaria
    “... and adaptive immune responses, and exhibit pivotal roles during Plasmodium spp. infection. Here, we analyzed...”
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  8. 1148
    The Role of Autophagy in M2 Polarization of Macrophages Induced by Micro/Nano Topography
    por Luo J, He Y, Meng F, Yan N, Zhang Y, Song W
    Publicado 2020
    “... treatment.Conclusion: Our findings suggest that the ERK-Beclin-1-autophagy axis may play a pivotal role...”
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  9. 1149
    Mangrove roots model suggest an optimal porosity to prevent erosion
    “... dominated the turbulence production to obstruct the sediment transport. This work identified the pivotal...”
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  10. 1150
    Probability maps of anthropogenic impacts affecting ecological status in European rivers
    “...Understanding how anthropogenic pressures affect river ecological status is pivotal to designing...”
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  11. 1151
    Exploring the transition effects of foreign direct investment on the eco-efficiency of Chinese cities: Based on multi-source data and panel smooth transition regression models
    por Yun Tong, Haifeng Zhou, Lei Jiang
    Publicado 2021
    “... to promote economic growth in China, but also has played a pivotal role in the ecological environment...”
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  12. 1152
    Quetiapine monotherapy for bipolar depression
    por Michael E Thase
    Publicado 2008
    “... as the result of two pivotal trials known by the acronyms of BOLDER (BipOLar DEpRession) I and II. Both studies...”
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  13. 1153
    rDNA insulin glargine U300 – a critical appraisal
    por Wang F, Zassman S, Goldberg PA
    Publicado 2016
    “... searched reference lists of pertinent reviews and trials.Results: A total of 6 pivotal Phase III randomized...”
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  14. 1154
    Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [14C]-doxorubicin
    “...: Development of parameters for the fabrication of nanosized vectors is pivotal for its successful...”
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  15. 1155
    Facile one-step coating approach to magnetic submicron particles with poly(ethylene glycol) coats and abundant accessible carboxyl groups
    por Long GB, Yang XL, Zhang Y, Pu J, Liu L, Liu HB, Li YL, Liao F
    Publicado 2013
    “...*These authors contributed equally to this workPurpose: Magnetic submicron particles (MSPs) are pivotal...”
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  16. 1156
    Challenging obesity, diabetes, and addiction: the potential of lorcaserin extended release
    por Hurt RT, Mundi MS, Ebbert JO
    Publicado 2018
    “... and has been shown to be bioequivalent to lorcaserin IR (twice daily) in a pivotal study. Lorcaserin XRs...”
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  17. 1157
    Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
    “... endothelial growth factor (VEGF) plays a pivotal role in vascular changes in asthma. Mucin proteins MUC5AC...”
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  18. 1158
    Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer
    “.... Accumulating evidences suggest that circRNA plays pivotal roles in cancer initiation and development. However...”
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  19. 1159
    Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation.
    “... and Hsp70, but remarkably, although the presence of the Hsp70 chaperone as such appears pivotal...”
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  20. 1160
    VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV.
    “... receptors play pivotal roles at 14 days after laser. In vivo imaging demonstrated accumulation of GFP...”
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