Mostrando 61 - 80 Resultados de 899 Para Buscar '"p53"', tiempo de consulta: 0.15s Limitar resultados
  1. 61
    Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E.
    “...F-box and WD repeat domain-containing 7 (Fbxw7/hAgo/hCdc4/Fbw7) is a p53-dependent tumor suppressor...”
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  2. 62
    Suppression of autophagy promotes fibroblast activation in p53-deficient colorectal cancer cells
    “...Abstract Deficiency of p53 in cancer cells activates the transformation of normal tissue...”
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  3. 63
    Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen
    “...H driver mutation in the p53 oncogene (p53R175H) alone and bound to p53R175H–HLA-A2, which...”
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  4. 64
    DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
    “... growth and proliferation, partly by being required for p53’s ubiquitination and degradation....”
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  5. 65
    Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
    “...MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here...”
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  6. 66
    Mad1 destabilizes p53 by preventing PML from sequestering MDM2
    “... role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies...”
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  7. 67
    BRD4-mediated repression of p53 is a target for combination therapy in AML
    “... compounds can synergize through both p53 protein stabilization and inhibition of BRD4-mediated repression...”
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  8. 68
    Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
    “...p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions...”
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  9. 69
    Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
    “... is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a...”
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  10. 70
    MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
    “...; therefore, we hypothesized that targeting the p53 regulator Murine double minute 4 (MDM4) to reactivate p53...”
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  11. 71
    Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.
    “...Human VRK1 induces a stabilization and accumulation of p53 by specific phosphorylation in Thr18...”
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  12. 72
    p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
    Materias: “...p53...”
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  13. 73
    Development of a novel senolytic by precise disruption of FOXO4-p53 complex
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  14. 74
    ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53
    Materias: “...p53...”
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  15. 75
    Predicting transcriptional activity of multiple site p53 mutants based on hybrid properties.
    “...As an important tumor suppressor protein, reactivate mutated p53 was found in many kinds of human...”
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  16. 76
    Modeling a new water channel that allows SET9 to dimethylate p53.
    “... Lys372 of p53 (p53-K372) and Lys4 of histone H3 (H3-K4). In order to understand how p53 can...”
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  17. 77
    Activation of Notch signaling is required for cholangiocarcinoma progression and is enhanced by inactivation of p53 in vivo.
    “...) and inactivation of tumor suppressor p53. GSI IX treatment effectively impaired cell proliferation, migration...”
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  18. 78
    β-Catenin C-terminal signals suppress p53 and are essential for artery formation
    “...How p53 is restrained in arterial maturation during embryonic development is unclear. Here...”
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  19. 79
    The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia
    “... the apoptotic cell death. In this context, p53 is a stress sensor that accumulates during brain ischemia leading...”
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  20. 80
    Selective therapeutic strategy for p53-deficient cancer by targeting dysregulation in DNA repair
    “...Zonneville et al. show that p53 mutant cancers express high levels of the Base Excision Repair (BER...”
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