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1“...Almost all allosteric systems are large multi-domain proteins which complicates the investigation...”
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2por Jian Wang, Abha Jain, Leanna R. McDonald, Craig Gambogi, Andrew L. Lee, Nikolay V. Dokholyan“... function and cellular activity. Here, the authors develop a network-based method to detect allosteric...”
Publicado 2020
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6por Zanlin Yu, Yadong Yu, Feng Wang, Alexander G. Myasnikov, Philip Coffino, Yifan Cheng“... archaeal proteasomes and reveal allosteric coupling between the conformations of gates in the α-rings...”
Publicado 2020
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7“... to characterize epistasis in a computationally redesigned ligand-inducible allosteric transcription factor...”
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8por Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland“... of serotonin transport and binds with nanomolar affinity to an allosteric site in SERT....”
Publicado 2021
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9“... allosteric mechanism of action. Using a validated homology model of inactive VPAC1 and a recently released...”
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10por João P. Pisco, Cesira de Chiara, Kamila J. Pacholarz, Acely Garza-Garcia, Roksana W. Ogrodowicz, Philip A. Walker, Perdita E. Barran, Stephen J. Smerdon, Luiz Pedro S. de Carvalho“..., suggesting that dynamic alterations are involved in ATP-PRT regulation by allosteric modulators....”
Publicado 2017
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11“.... This phenomenon is analogous to allosteric regulation in proteins, where a conformational change triggered...”
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12“...Allosteric regulation involves conformational transitions or fluctuations between a few closely...”
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13por Dawid Deneka, Sonja Rutz, Cedric A. J. Hutter, Markus A. Seeger, Marta Sawicka, Raimund Dutzler“... and allosterically modulate the function of homomeric LRRC8A and endogenous heteromeric channels, hinting...”
Publicado 2021
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14por Per Plenge, Ara M. Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J. Loland“... in SERT and a high-affinity ligand for the allosteric site....”
Publicado 2020
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16“... of allosteric proteins, be they receptors, ion-channels, signalling molecules or transcription factors...”
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18por Garima Jaipuria, Andrei Leonov, Karin Giller, Suresh Kumar Vasa, Łukasz Jaremko, Mariusz Jaremko, Rasmus Linser, Stefan Becker, Markus Zweckstetter“... that cholesterol binding to TSPO results in allosteric changes that modulate TSPO oligomerization....”
Publicado 2017
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19por Toby A. Dite, Naomi X. Y. Ling, John W. Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L. Parker, Kevin R. W. Ngoei, Christopher G. Langendorf, Matthew T. O’Brien, Mondira Kundu, Benoit Viollet, Gregory R. Steinberg, Kei Sakamoto, Bruce E. Kemp, Jonathan S. Oakhill“... phosphorylates β1-Ser108 on the regulatory β1-subunit, sensitizing AMPK to allosteric drugs, and activates...”
Publicado 2017
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20por Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell“.... tuberculosis CoaB that bind to an allosteric site within CoaB....”
Publicado 2021
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