Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer

por Guru Sonpavde, Na Li, Zheng Zhu, Fan Cheng, Shaoming Zhu, A-Hong Ma, Elio Adib, Ting Rao, Kaiyuan Ni, Veera Chandra Sekhar Reddy Chittepu, Rao Prabhala, Juan Garisto Risco, David Kwiatkowski, Kent Mouw, Chong-xian Pan
Publicado 2021

Risk of long-term benzodiazepine and Z-drug use following the first prescription among community-dwelling adults with anxiety/mood and sleep disorders: a retrospective cohort study

por Dan Chateau, Alexander Singer, Silvia Alessi-Severini, Jaden Brandt, Donica Janzen, Murray Enns, Christine Leong
Publicado 2021

KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF-mutant melanoma

por Antoni Ribas, Inge Marie Svane, Paolo Antonio Ascierto, Victoria Atkinson, Razi Ghori, Anna Maria Di Giacomo, Georgina V Long, Henrik Schmidt, Jacob Schachter, Eduard Gasal, Paola Queirolo, Michal Lotem, Michele Del Vecchio, Pier Francesco Ferrucci, Rosalie Stephens, Mahmoud Abu-Amna, Scott J Diede, Elizabeth S Croydon
Publicado 2020

Effect of menstrual cycle phase, menstrual irregularities and hormonal contraceptive use on anterior knee laxity and non-contact anterior cruciate ligament injury occurrence in wom...

por Kirsty Jayne Elliott-Sale, Paul A Swinton, Eimear Dolan, Craig Sale, Sandra J Shultz, Elisa Nédélec, Elvis Foli, Jessica Piasecki, Joseph J Matthews
Publicado 2021

Risk of common infections in people with inflammatory bowel disease in primary care: a population-based cohort study

por Peter M Irving, Kevin Barrett, Daniel Tang, Monica Nijher
Publicado 2021

Overexpression of CD200 is a stem cell-specific mechanism of immune evasion in AML

por R Eric Davis, Marina Konopleva, Natalia Baran, Gheath Al-Atrash, Naval Daver, Shelley Herbrich, Tianyu Cai, Connie Weng, Marisa J L Aitken, Sean M Post, Jared Henderson, Chunhua Shi, Guillame Richard-Carpentier, Guy Sauvageau, Keith Baggerly, Dongxing Zha, Ondrej Havranek
Publicado 2021

Fast decliner phenotype of chronic obstructive pulmonary disease (COPD): applying machine learning for predicting lung function loss

por David B Price, Vasilis Nikolaou, Sebastiano Massaro, Wolfgang Garn, Masoud Fakhimi, Lampros Stergioulas
Publicado 2021

Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity

por Shunichi Taki, Kohei Matsuoka, Yuko Nishinaga, Kazuomi Takahashi, Hirotoshi Yasui, Chiaki Koike, Misae Shimizu, Mitsuo Sato, Kazuhide Sato
Publicado 2021

Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy

por David Lawson, Zachary S Buchwald, Tahseen H Nasti, Judong Lee, Christiane S Eberhardt, Se Jin Im, Walter Curran, Rafi Ahmed, Mohammad K Khan, Andreas Wieland
Publicado 2020

Precision antiplatelet therapy for the prevention of ischaemic stroke

por David Wang

Differences in problem alcohol drinking by military service type among male professional military personnel in South Korea using Military Health Survey data

por Jeongok Park, Eunyoung Jung, Eunkyoung Bae
Publicado 2021

iColon, a patient-focused mobile application for perioperative care in colorectal surgery: an observational, real-world study protocol

por Massimo Guerriero, Teresa Zuppini, Elisa Bertocchi, Giuliano Barugola, Irene Gentile, Massimo Zamperini, Renato Avesani, Silvia Bonadiman, Chiara Anselmi, Giacomo Ruffo
Publicado 2021

Effects of a lifestyle intervention programme after 1 year of follow-up among South Asians at high risk of type 2 diabetes: a cluster randomised controlled trial

por Sajjad Ahmad, Gary S Frost, Jonathan Valabhji, Marjo-Riitta Järvelin, Anuradhani Kasturiratne, Mirthe Muilwijk, Prasad Katulanda, Khurram Shahzad, Sara Mahmood, Jaspal S Kooner, John C Chambers, Saranya Palaniswamy, Irene GM van Valkengoed, Rajitha Wickremasinghe, Samreen Siddiqui, Sujeet Jha, Swati Waghdhare, Marie Loh, Heather M Gage, Lathika K Athauda, Ranil Jayawardena, Tayyaba Batool, Saira Burney, Matthew Glover, Vodathi Bamunuarachchi, Manju Panda, Madawa Madawanarachchi, Baldeesh Rai, Iqra Sattar, Wnurinham Silva, Ravindra Prasan Rannan-Eliya, Nilmini Wijemunige, Khadija I Khawaja
Publicado 2021

Impact of zero-mark-up medicines policy on hospital revenue structure: a panel data analysis of 136 public tertiary hospitals in China, 2012–2020

por Yuanli Liu, Jing Sun, Hanchao Cheng, Yuou Zhang
Publicado 2021

Synergy between Toxoplasma gondii type I ΔGRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors

por Jia Chen, Yu-Chao Zhu, Hany M Elsheikha, Jian-Hua Wang, Shuai Fang, Jun-Jun He, Xing-Quan Zhu
Publicado 2021

Correction: GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors

Publicado 2021

Contrasting role of NLRP12 in autoinflammation: evidence from a case report and mouse models

por Alain Meyer, François Maurier, Angélique Pichot, Philippe Georgel, Raphael Carapito, Anne Molitor, Dan Lévy, Alexandre Mariotte, Aurore DeCauwer, Cecile Macquin
Publicado 2021

Projections of human papillomavirus (HPV) vaccination impact in Ethiopia, India, Nigeria and Pakistan: a comparative modelling study

por Kaja Abbas, Jane J Kim, Allison Portnoy, Steven Sweet
Publicado 2021

BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism

por Jun Ma, Kristen Hurov, Johanna lahdenranta, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Fanglei You, Mike Kelly, Heather Cohen, Drasti Kanakia, Carly Campbell, David Witty, Stephen Blakemore, Phil Jeffrey
Publicado 2021

Importance of accounting for loss to follow-up when comparing mortality between immigrants and long-term residents: a population-based retrospective cohort

por Moira K Kapral, Andreas Laupacis, Jiming Fang, Manav V. Vyas, Peter C. Austin, Matthew C. Cheung, Frank L. Silver
Publicado 2021