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  1. 12561
    Pooled library screening with multiplexed Cpf1 library
    “...AsCpf1 is an alternative nuclease to Cas9 for CRISPR mediated genome engineering. Here the authors...”
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  2. 12562
    Deciphering functional redundancy in the human microbiome
    “...Here, the authors develop a genome evolution model to investigate the origin of functional...”
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  3. 12563
    Revealing Hi-C subcompartments by imputing inter-chromosomal chromatin interactions
    por Kyle Xiong, Jian Ma
    Publicado 2019
    “...Genome-wide mapping of chromatin interactions reveals various levels of 3D genome organization...”
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  4. 12564
    Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs
    “...Cancer genomic data sets contain a wealth of data that can be used to predict prognosis and further...”
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  5. 12565
    Patterns of polymorphism and selection in the subgenomes of the allopolyploid Arabidopsis kamchatica
    “...Despite the prevalence of genome duplication in plants, little is known about the evolutionary...”
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  6. 12566
    Innovation and constraint leading to complex multicellularity in the Ascomycota
    “... multicellularity. Here, the authors combine genome sequencing with comparative and functional genomics to identify...”
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  7. 12567
    CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci
    “...The ability to target Cas9 to specific genomic loci offers the potential for applications beyond...”
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  8. 12568
    Real-Time Imaging of Polioviral RNA Translocation across a Membrane
    “... The initial transfer of genomic material from a virus into a host cell is a key step in any viral...”
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  9. 12569
    Undinarchaeota illuminate DPANN phylogeny and the impact of gene transfer on archaeal evolution
    “...The evolutionary relationships within Archaea remain unresolved. Here, the authors used genomic...”
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  10. 12570
    Pangenomics reveals alternative environmental lifestyles among chlamydiae
    “... but the diversity of the phylum is not well described. Here, the authors analyze 82 metagenome-assembled genomes...”
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  11. 12571
    Identification and characterization of constrained non-exonic bases lacking predictive epigenomic and transcription factor binding annotations
    “...Genome-wide maps of evolutionary constraint and large-scale compendia of epigenomic...”
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  12. 12572
    Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
    “...Cas9 and Cpf1 have both been adapted for genome engineering, editing and gene expression regulation...”
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  13. 12573
    PAN2HGENE-tool for comparative analysis and identifying new gene products.
    “... research, leading to the development of numerous omics approaches, including genomics, transcriptomics...”
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  14. 12574
    Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.
    “..., we investigate two factors that are predicted to influence the mutation rate: ecology and genome size...”
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  15. 12575
    Multiple Trait Covariance Association Test Identifies Gene Ontology Categories Associated with Chill Coma Recovery Time in Drosophila melanogaster
    “...Abstract The genomic best linear unbiased prediction (GBLUP) model has proven to be useful...”
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  16. 12576
    Pattern of Repetitive Element Transcription Segregate Cell Lineages during the Embryogenesis of Sea Urchin <i>Strongylocentrotus purpuratus</i>
    “...Repetitive elements (REs) occupy a significant part of eukaryotic genomes and are shown to play...”
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  17. 12577
    Inbreeding Calculated with Runs of Homozygosity Suggests Chromosome-Specific Inbreeding Depression Regions in Line 1 Hereford
    “... phenotype in the Line 1 Hereford cattle population were assessed in this study. Genomic data were used...”
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  18. 12578
    Next-generation mammalian genetics toward organism-level systems biology
    “... studies of genome-edited animals are completed within a single generation drastically reduce the time...”
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  19. 12579
    Heterotrophic euglenid Rhabdomonas costata resembles its phototrophic relatives in many aspects of molecular and cell biology
    “... partial genomic sequence of Euglena gracilis and transcriptomes of several phototrophic and secondarily...”
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  20. 12580
    CRISPR-Cas9 cleavage efficiency correlates strongly with target-sgRNA folding stability: from physical mechanism to off-target assessment
    por Xiaojun Xu, Dongsheng Duan, Shi-Jie Chen
    Publicado 2017
    “... for RNA-guided genome editing and transcription regulation in applications such as targeted genome...”
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