Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

por Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames
Publicado 2021

Unraveling the dynamic importance of county-level features in trajectory of COVID-19

por Qingchun Li, Yang Yang, Wanqiu Wang, Sanghyeon Lee, Xin Xiao, Xinyu Gao, Bora Oztekin, Chao Fan, Ali Mostafavi
Publicado 2021

Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases

por Yuling Wu, Caixia Lu, Nana Pan, Meng Zhang, Yi An, Mengyuan Xu, Lijuan Zhang, Yachong Guo, Lijuan Tan
Publicado 2021

Risk factor for elbow symptom manifestation in young baseball players with asymptomatic medial elbow abnormalities: a prospective cohort study

por Hitoshi Shitara, Tsuyoshi Tajika, Takuro Kuboi, Tsuyoshi Ichinose, Tsuyoshi Sasaki, Noritaka Hamano, Fumitaka Endo, Masataka Kamiyama, Ryosuke Miyamoto, Kurumi Nakase, Atsushi Yamamoto, Tsutomu Kobayashi, Kenji Takagishi, Hirotaka Chikuda
Publicado 2021

Endoscopic hematoma removal of supratentorial intracerebral hemorrhage under local anesthesia reduces operative time compared to craniotomy

por Masahito Katsuki, Yukinari Kakizawa, Akihiro Nishikawa, Yasunaga Yamamoto, Toshiya Uchiyama
Publicado 2020

The neurodynamic treatment induces biological changes in sensory and motor neurons in vitro

por Giacomo Carta, Giovanna Gambarotta, Benedetta Elena Fornasari, Luisa Muratori, Marwa El Soury, Stefano Geuna, Stefania Raimondo, Federica Fregnan
Publicado 2021

The learning curve of the distal radial access for coronary intervention

por Ji Woong Roh, Yongcheol Kim, Oh-Hyun Lee, Eui Im, Deok-Kyu Cho, Donghoon Choi, Myung Ho Jeong
Publicado 2021

Molecular characterization of sequence-driven peptide glycation

por Michelle T. Berger, Daniel Hemmler, Alesia Walker, Michael Rychlik, James W. Marshall, Philippe Schmitt-Kopplin
Publicado 2021

Intermittent decoherence blockade in a chiral ring environment

por Salvatore Lorenzo, Stefano Longhi, Albert Cabot, Roberta Zambrini, Gian Luca Giorgi
Publicado 2021

Post-match recovery profile of leukocyte cell subsets among professional soccer players

por Dorota Kostrzewa-Nowak, Paweł Wityk, Andrzej Ciechanowicz, Robert Nowak
Publicado 2021

Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

por Fredarla S. Miller, Kathryn K. Crone, Matthew R. Jensen, Sudipta Shaw, William R. Harcombe, Mikael H. Elias, Michael F. Freeman
Publicado 2021

Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures

por Moisès Coll Macià, Laurits Skov, Benjamin Marco Peter, Mikkel Heide Schierup
Publicado 2021

Breaking the acoustic diffraction limit with an arbitrary shape acoustic magnifying lens

por Ali Abdolali, Hooman Barati Sedeh, Mohammad Hosein Fakheri, Chen Shen, Fei Sun
Publicado 2021

Transport in helical Luttinger liquids in the fractional quantum Hall regime

por Ying Wang, Vadim Ponomarenko, Zhong Wan, Kenneth W. West, Kirk W. Baldwin, Loren N. Pfeiffer, Yuli Lyanda-Geller, Leonid P. Rokhinson
Publicado 2021

Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans

por Alice Corrêa Silva-Sousa, Guido Artemio Marañón-Vásquez, Maria Bernadete Sasso Stuani, Peter Proff, Kesly Mary Ribeiro Andrades, Flares Baratto-Filho, Mírian Aiko Nakane Matsumoto, Eva Paddenberg, Erika Calvano Küchler, Christian Kirschneck
Publicado 2021

Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms

por Guogang Deng, Shengzu Duan, Jing Wang, Zhuo Chen, Tongqi Liu, Wen Chen, Hongbin Zhang, Xiaodong Yang, Patrick J. Walsh
Publicado 2021

Mantle-derived helium released through the Japan trench bend-faults

por Jin-Oh Park, Naoto Takahata, Ehsan Jamali Hondori, Asuka Yamaguchi, Takanori Kagoshima, Tetsuro Tsuru, Gou Fujie, Yue Sun, Juichiro Ashi, Makoto Yamano, Yuji Sano
Publicado 2021

Mining and unearthing hidden biosynthetic potential

por Kirstin Scherlach, Christian Hertweck
Publicado 2021

Effects of large herbivore grazing on relics of the presumed mammoth steppe in the extreme climate of NE-Siberia

por Jennifer Reinecke, Kseniia Ashastina, Frank Kienast, Elena Troeva, Karsten Wesche
Publicado 2021

miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling

por Matthew Knarr, Rita A. Avelar, Sreeja C. Sekhar, Lily J. Kwiatkowski, Michele L. Dziubinski, Jessica McAnulty, Stephanie Skala, Stefanie Avril, Ronny Drapkin, Analisa DiFeo
Publicado 2020